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Database: UniProt/TrEMBL
Entry: G3X211_SARHA
LinkDB: G3X211_SARHA
Original site: G3X211_SARHA 
ID   G3X211_SARHA            Unreviewed;       690 AA.
AC   G3X211;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 42.
DE   SubName: Full=Transglutaminase 2 {ECO:0000313|Ensembl:ENSSHAP00000021716};
GN   Name=TGM2 {ECO:0000313|Ensembl:ENSSHAP00000021716};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000021716, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000021716}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000021716}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000021716}.
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DR   EMBL; AEFK01019424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01019425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012409032.1; XM_012553578.1.
DR   STRING; 9305.ENSSHAP00000021716; -.
DR   Ensembl; ENSSHAT00000021890; ENSSHAP00000021716; ENSSHAG00000018388.
DR   GeneID; 100930830; -.
DR   KEGG; shr:100930830; -.
DR   CTD; 7052; -.
DR   eggNOG; ENOG410IFMV; Eukaryota.
DR   eggNOG; ENOG410XQEZ; LUCA.
DR   GeneTree; ENSGT00760000119108; -.
DR   InParanoid; G3X211; -.
DR   KO; K05625; -.
DR   OMA; AHITNNT; -.
DR   OrthoDB; EOG091G030K; -.
DR   TreeFam; TF324278; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:GOC.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR   GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR   GO; GO:0031226; C:intrinsic component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:Ensembl.
DR   GO; GO:0043277; P:apoptotic cell clearance; IEA:Ensembl.
DR   GO; GO:0060445; P:branching involved in salivary gland morphogenesis; IEA:Ensembl.
DR   GO; GO:0032471; P:negative regulation of endoplasmic reticulum calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl.
DR   GO; GO:0051561; P:positive regulation of mitochondrial calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0060662; P:salivary gland cavitation; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT   DOMAIN      269    361       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    277    277       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    335    335       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    358    358       {ECO:0000256|PIRSR:PIRSR000459-1}.
SQ   SEQUENCE   690 AA;  78551 MW;  E7AEDF80B9E337BB CRC64;
     MASELIVEKS DLEFEKNGKN HWTSSMCQDK LVVRRGQPFN IVIYFQDRGF EASVDKLNFI
     VETGPYPSEA AGTKAKFPLS DFVQEGVWAA TVIGQENNVL YLTISSPPHA PIGYYKLLIE
     TFTGSYNNIF SITGFILLFN PWCQADSVYV ENDDFRKEYV LNQHGIIFQG SYKYVNKIPW
     NFGQFEDGII DICIELLDMN PKFFKDPRRD CCRRSSPIYI SRVISAMVNC NDDKGILYGR
     WDNYYMDGVS PMAWIGSVDI LRKWKMSGCH PVKYGQCWVF AAVACTVMRC LGIPTRVVTN
     YNSAHDSNSN LTIEVYRDER GEVLMNKSET VWNYHCWIEA WMARPDLKPE YNGWQAIDPT
     PQEKSEGTYC CGPASIKAIK NGEVNTKYDA PFVFAEINAD VVNWIKESDG DFKKLYTKTM
     IVGVMISTKA IGKDEREDVT HHYKYPEGSE EERETYKRAN HLNKLSLTNE HSLVEDVKIK
     IKVSPNMSKG NDFDVFGVIN NNSSEEQSCH LLMAARTVTY NGRLGPECAK TEQLSLAVEP
     LSEKIIPLRI CYSEYQKYLD ESNLIKVKML LQVLQSETFL MAERDIYLVN PEIKIRILGE
     PKKLRKLVAE LSLKNPLPVP LDNCIFTAEG AGLTPVQKIV HIPDPVEPGN IVTTRVDLMP
     QWPGLHKLVV NFESDKMKGV KGYWNVIVGP
//
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