ID G7W096_PAETH Unreviewed; 747 AA.
AC G7W096;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 03-APR-2013, entry version 10.
DE RecName: Full=Phosphoribosylformylglycinamidine synthase 2;
DE EC=6.3.5.3;
DE AltName: Full=Phosphoribosylformylglycinamidine synthase II;
GN Name=purL; OrderedLocusNames=HPL003_11785;
OS Paenibacillus terrae (strain HPL-003).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae;
OC Paenibacillus.
OX NCBI_TaxID=985665;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HPL-003;
RA Shin S.H., Kim S., Kim J.Y.;
RT "Complete sequence of Paenibacillus terrae HPL-003.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HPL-003;
RA Shin S.H., Kim S., Kim J.Y.;
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: ATP + N(2)-formyl-N(1)-(5-phospho-D-
CC ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-
CC (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC phospho-D-ribosyl)glycinamide: step 1/2.
CC -!- SUBUNIT: Heterodimer of two subunits, PurQ and PurL (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the FGAMS family.
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DR EMBL; CP003107; AET59114.1; -; Genomic_DNA.
DR RefSeq; YP_005075337.1; NC_016641.1.
DR EnsemblBacteria; AET59114; AET59114; HPL003_11785.
DR GeneID; 11583657; -.
DR KEGG; pta:HPL003_11785; -.
DR KO; K01952; -.
DR OMA; WSEHCCY; -.
DR UniPathway; UPA00074; UER00128.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:HAMAP.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00420; PurL_2; 1; -.
DR InterPro; IPR010918; AIR_synth_C_dom.
DR InterPro; IPR000728; AIR_synth_N_dom.
DR InterPro; IPR010074; PRibForGlyAmidine_synth_II.
DR InterPro; IPR016188; PurM_N-like.
DR Pfam; PF00586; AIRS; 2.
DR Pfam; PF02769; AIRS_C; 2.
DR SUPFAM; SSF56042; AIR_synth_C; 2.
DR SUPFAM; SSF55326; PurM_N-like; 2.
DR TIGRFAMs; TIGR01736; FGAM_synth_II; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding;
KW Purine biosynthesis.
FT NP_BIND 114 125 ATP (By similarity).
SQ SEQUENCE 747 AA; 79954 MW; 3AADADBA41202182 CRC64;
MAQQVSAKEP TAEQVAEHKL YQQMGVSDSE YALICEFMGR QPNYTEIGVF SVMWSEHCAY
KNSKPLLRRF PTSGPRVLMG PGEGAGIVDI GDNQAVVFKI ESHNHPSAVE PFQGAATGVG
GIIRDIFSMG ARPVAVLNSL RFGKLESDRV KYLFEHVVSG IAGYGNCIGI PTVGGEVVFD
ESYEGNPLVN AMCVGLIDHD KIQRGVAKGV GNPVFYVGPP TGRDGIHGAT FASVELTEES
EANRTAVQVG DPFMEKLVME SCLELIDSGI VLGIQDMGAA GLTCSSAEMA SKAGNGLELY
LDQVPQREEG MTPYEMMLSE SQERMLFVVE PKDEAQALEI FERWGVICAK VGKVTDDGRL
RLFHHGDVVG DMPVTALVDE CPIYDKPSEV PAYYEQNAAI DTLRYAEVTD LNGALKKVLS
SPSVASKKWV YEQYDYMVRT STAVRPGSDA AVVTVRGTRK GLAMTTDCNG RYVYLDPEVG
GRIAVSEAAR NIVCSGGEPL AITDNLNFGN PEKPDIFWQM EKAVDGMAEA CRVLDTPVIG
GNVSLYNENA KGSIYPTPVV GMVGLVHDTD HITTQGFKAE GDVIFLVGET KAELGGSEFQ
AVVHGVSEGR PPELDLNVEK KLLNAVLSAI QTGLVQSAHD LAEGGLAVAL AESGISGGLG
AQVNVETTLR PDHALFSESQ SRILLSASPD KASALEAHLR GLGVPVTVLG KVEGSQLTVE
VNGQPALNEA VASLKQIWED VIPCLMK
//
