ID G8LY95_CLOCD Unreviewed; 251 AA.
AC G8LY95;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 29-MAY-2013, entry version 14.
DE RecName: Full=Triosephosphate isomerase;
DE Short=TIM;
DE EC=5.3.1.1;
DE AltName: Full=Triose-phosphate isomerase;
GN Name=tpiA; OrderedLocusNames=Clocl_1154;
OS Clostridium clariflavum (strain DSM 19732 / NBRC 101661 / EBR45).
OC Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=720554;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19732 / NBRC 101661 / EBR45;
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Pagani I., Kitzmiller T., Lynd L.,
RA Izquierdo J., Woyke T.;
RT "Complete sequence of Clostridium clariflavum DSM 19732.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone
CC phosphate.
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate from glycerone phosphate: step 1/1.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
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DR EMBL; CP003065; AEV67826.1; -; Genomic_DNA.
DR RefSeq; YP_005045750.1; NC_016627.1.
DR ProteinModelPortal; G8LY95; -.
DR EnsemblBacteria; AEV67826; AEV67826; Clocl_1154.
DR GeneID; 11561523; -.
DR KEGG; ccl:Clocl_1154; -.
DR KO; K01803; -.
DR BioCyc; CCLA720554:GI2T-1152-MONOMER; -.
DR UniPathway; UPA00109; UER00189.
DR UniPathway; UPA00138; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:HAMAP.
DR GO; GO:0006094; P:gluconeogenesis; IEA:HAMAP.
DR GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:HAMAP.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00147_B; TIM_B; 1; -.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR022896; TrioseP_Isoase_bac/euk.
DR InterPro; IPR000652; Triosephosphate_isomerase.
DR InterPro; IPR020861; Triosephosphate_isomerase_AS.
DR PANTHER; PTHR21139; PTHR21139; 1.
DR Pfam; PF00121; TIM; 1.
DR SUPFAM; SSF51351; Triophos_ismrse; 1.
DR TIGRFAMs; TIGR00419; tim; 1.
DR PROSITE; PS00171; TIM_1; 1.
DR PROSITE; PS51440; TIM_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase;
KW Pentose shunt.
FT ACT_SITE 95 95 Electrophile (By similarity).
FT ACT_SITE 167 167 Proton acceptor (By similarity).
FT BINDING 10 10 Substrate (By similarity).
FT BINDING 12 12 Substrate (By similarity).
SQ SEQUENCE 251 AA; 27131 MW; 742008FDECF0C3DE CRC64;
MSRVKIAAGN WKMNKTAKEA VEFVEALKPR VADADAEVVV GVPFVCIPGV KKAVEGSNIK
VAAQNIHWEE KGAFTGEVSG PMLADLGVDY VIIGHSERRQ YFAETDETVN KKAHAVFKYG
MKPIICVGES LTQREQGVTA ELVRYQVKIA LLGLTAEQVK ETVIAYEPIW AIGTGKTATT
EQAEEVCAII RNVVKELYGD DVAQAIRIQY GGSVNAANAA ELFAMPNIDG GLVGGASLKL
DDFEKIAKYN K
//
