ID G8UIQ1_TANFA Unreviewed; 539 AA.
AC G8UIQ1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN OrderedLocusNames=BFO_2207 {ECO:0000313|EMBL:AEW22573.1};
OS Tannerella forsythia (strain ATCC 43037 / JCM 10827 / CCUG 21028 A / KCTC
OS 5666 / FDC 338) (Bacteroides forsythus).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC Tannerella.
OX NCBI_TaxID=203275 {ECO:0000313|EMBL:AEW22573.1, ECO:0000313|Proteomes:UP000005436};
RN [1] {ECO:0000313|Proteomes:UP000005436}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43037 / JCM 10827 / CCUG 33226 / KCTC 5666 / FDC 338
RC {ECO:0000313|Proteomes:UP000005436};
RA Dewhirst F., Tanner A., Izard J., Brinkac L., Durkin A.S., Hostetler J.,
RA Shetty J., Torralba M., Gill S., Nelson K.;
RT "Complete sequence of Tannerella forsythia ATCC 43037.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007829|PDB:7QXO, ECO:0007829|PDB:7QY8}
RP X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS) OF 21-539.
RX PubMed=35916484; DOI=10.1042/bcj20220244;
RA Satur M.J., Urbanowicz P.A., Spencer D.I.R., Rafferty J., Stafford G.P.;
RT "Structural and functional characterisation of a stable, broad-specificity
RT multimeric sialidase from the oral pathogen Tannerella forsythia.";
RL Biochem. J. 479:1785-1806(2022).
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DR EMBL; CP003191; AEW22573.1; -; Genomic_DNA.
DR RefSeq; WP_014225510.1; NC_016610.1.
DR PDB; 7QXO; X-ray; 1.90 A; A/B=21-539.
DR PDB; 7QY8; X-ray; 2.06 A; A/B=21-539.
DR PDB; 7QY9; X-ray; 1.92 A; A/B=21-539.
DR PDB; 7QYJ; X-ray; 2.11 A; A/B=21-539.
DR PDB; 7QYP; X-ray; 1.66 A; A/B=21-539.
DR PDB; 7QZ3; X-ray; 1.97 A; A/B=21-539.
DR AlphaFoldDB; G8UIQ1; -.
DR SMR; G8UIQ1; -.
DR STRING; 203275.BFO_2207; -.
DR GeneID; 34759268; -.
DR KEGG; tfo:BFO_2207; -.
DR PATRIC; fig|203275.8.peg.2003; -.
DR eggNOG; COG4409; Bacteria.
DR HOGENOM; CLU_024620_0_0_10; -.
DR OMA; GQTWEPM; -.
DR Proteomes; UP000005436; Chromosome.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.40.1290; -; 1.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR029456; Sialidase_N.
DR InterPro; IPR036278; Sialidase_sf.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF14873; BNR_assoc_N; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:7QXO, ECO:0007829|PDB:7QY8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005436}.
FT DOMAIN 20..169
FT /note="Sialidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14873"
FT DOMAIN 200..478
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
SQ SEQUENCE 539 AA; 59687 MW; 7442B2CB9D8853DB CRC64;
MKKFFWIIGL FASMQMTRAA DSVYVQNPQI PILVDRTDNV LFRIRIPDAT KGDVLNRLTI
RFGNEDKLSE VKAVRLFYAG TEAATKGRSR FAPVTYVSSH NIRNTRSANP SYSIRQDEVT
TVANTLTLKT RQPMVKGINY FWVSVEMDRN TSLLSKLTST VTEVVINDKP AVIAGEQAAV
RRMGIGVRHA GDDGSASFRI PGLVTTNKGT LLGVYDVRYN NSVDLQEHID VGLSRSTDKG
QTWEPMRIAM SFGETDGLPS GQNGVGDPSI LVDERTNTVW VVAAWTHGMG NARAWTNSMP
GMTPDETAQL MMVKSTDDGR TWSESTNITS QVKDPSWCFL LQGPGRGITM RDGTLVFPIQ
FIDSLRVPHA GIMYSKDRGE TWHIHQPART NTTEAQVAEV EPGVLMLNMR DNRGGSRAVS
ITRDLGKSWT EHSSNRSALP ESICMASLIS VKAKDNIIGK DLLLFSNPNT TEGRHHITIK
ASLDGGVTWL PAHQVLLDEE DGWGYSCLSM IDRETVGIFY ESSVAHMTFQ AVKIKDLIR
//