GenomeNet

Database: UniProt/TrEMBL
Entry: G8ZY51_TORDC
LinkDB: G8ZY51_TORDC
Original site: G8ZY51_TORDC 
ID   G8ZY51_TORDC            Unreviewed;       969 AA.
AC   G8ZY51;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   25-OCT-2017, entry version 33.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=TDEL0G04510 {ECO:0000313|EMBL:CCE93818.1};
GN   ORFNames=TDEL_0G04510 {ECO:0000313|EMBL:CCE93818.1};
OS   Torulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 /
OS   NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Torulaspora.
OX   NCBI_TaxID=1076872 {ECO:0000313|Proteomes:UP000005627};
RN   [1] {ECO:0000313|EMBL:CCE93818.1, ECO:0000313|Proteomes:UP000005627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866
RC   {ECO:0000313|Proteomes:UP000005627};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S.,
RA   Byrne K.P., Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type
RT   switching accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; HE616748; CCE93818.1; -; Genomic_DNA.
DR   RefSeq; XP_003683029.1; XM_003682981.1.
DR   ProteinModelPortal; G8ZY51; -.
DR   STRING; 4950.XP_003683029.1; -.
DR   EnsemblFungi; CCE93818; CCE93818; TDEL_0G04510.
DR   GeneID; 11505191; -.
DR   KEGG; tdl:TDEL_0G04510; -.
DR   InParanoid; G8ZY51; -.
DR   KO; K10777; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000005627; Chromosome 7.
DR   GO; GO:0032807; C:DNA ligase IV complex; IEA:EnsemblFungi.
DR   GO; GO:0000790; C:nuclear chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:EnsemblFungi.
DR   GO; GO:0001302; P:replicative cell aging; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF50249; SSF50249; 2.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005627};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005627}.
FT   DOMAIN      396    510       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      704    803       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      864    966       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   969 AA;  111242 MW;  BE41935B409BD40B CRC64;
     MESAEILTST HEVSQELQES ESTEKAPPNF APSPDFIWLC EELFVKLEDV QRQGREHLGN
     KPLSVRYYEV ISHFIRLWRK TVGNNIFPAL VLSLPYRDRR IYNIKDYTLV KAICSYLALP
     KQSATEKRLL KWKRRATRGV RLSNFCVEEI RKRKSEPSPG RRITIDKLNE CLDHLVEERN
     AKGGFKGLSD SPTFNFCLQN MSFIELRFFF DIVLKNRVIG GQEHKLLNCW HPDALDYLSV
     VSDLETVASR LWDPEHRLRR DDLSINLGYA FVPQLAKKMT ISYEKICTKL NNDFLIEEKM
     DGERIQVHYM DYGAKIRFLS RRGVDYTQLY GENLQSGTVA NYLNFDSNVR DCVLDGEMIT
     FDTDRNVVLP FGMVKSSARQ ALSTEGICSQ GHRPMLMVLD LVYLNGVSLI KLPLYQRKEF
     LNRVLKPCPH AVEILPYVRC SEHTAIRKSL EKSISMGSEG IVLKSYKARY EIGARNDYWI
     KVKPEYLEQF GENLDLVIIG RTPGKKDSLM CGLAVYEGEE DLNEIEAKRE SAIVNLDSEG
     DELDDTDGKK IIKYFISFCV IANGISQQEF KEIDRKTRGA WVKSDQRLPS ADLLRFGSKI
     PEEWIDPKNS IMLEVKARSL DNTESSKKKF AAGCTLHGGY CRRIRDDKDW TGCYSFSELW
     QERLHKSSTG VGSFNKQYSK KMKSKKRKID PFSGQAAKKH DVFDSTNIFK GLQFYVLSDY
     IDVSRNVRIT KSEFDDLILQ NSGKLVRNLI SKHHSESQFR IISGKYTAEC RALIERGYDI
     LSPQWILDCI RNRMVVKLEP RHCFNVSSEL MTIVNGRVDE YGDSFVNPIT EQQLDNLIDT
     NMKQTEPNLM REANSELDVV PLFLFSTRAV YIPPQVFNAV DAYGLTSKFK LHGGSIASDI
     PSCNLIIMPN ENQRLGTQSL VEMRQSVLQA MGRNDSTPSI PYIVTPDWVE KSIEENCQVP
     EEDFTPVYA
//
DBGET integrated database retrieval system