ID G9AL77_PANAN Unreviewed; 366 AA.
AC G9AL77;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 03-APR-2013, entry version 10.
DE RecName: Full=Ribosomal RNA large subunit methyltransferase M;
DE EC=2.1.1.186;
DE AltName: Full=23S rRNA (cytidine2498-2'-O)-methyltransferase;
DE AltName: Full=23S rRNA 2'-O-ribose methyltransferase RlmM;
GN Name=mtfA; Synonyms=rlmM; ORFNames=PANA5342_0938;
OS Pantoea ananatis LMG 5342.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Pantoea.
OX NCBI_TaxID=1123863;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=LMG 5342;
RX PubMed=22374951; DOI=10.1128/JB.06715-11;
RA De Maayer P., Chan W.Y., Rezzonico F., Buhlmann A., Venter S.N.,
RA Blom J., Goesmann A., Frey J.E., Smits T.H., Duffy B., Coutinho T.A.;
RT "Complete Genome Sequence of Clinical Isolate Pantoea ananatis LMG
RT 5342.";
RL J. Bacteriol. 194:1615-1616(2012).
CC -!- FUNCTION: Catalyzes the 2'-O-methylation at nucleotide C2498 in
CC 23S rRNA (By similarity).
CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + cytidine(2498) in
CC 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(2498)
CC in 23S rRNA.
CC -!- SUBUNIT: Monomer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. RlmE
CC family. RlmM subfamily.
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DR EMBL; HE617160; CCF08331.1; -; Genomic_DNA.
DR RefSeq; YP_005194368.1; NC_016816.1.
DR EnsemblBacteria; CCF08331; CCF08331; PANA5342_0938.
DR GeneID; 11795482; -.
DR KEGG; plf:PANA5342_0938; -.
DR KO; K06968; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:HAMAP.
DR GO; GO:0006364; P:rRNA processing; IEA:HAMAP.
DR HAMAP; MF_01551; 23SrRNA_methyltr_M; 1; -.
DR InterPro; IPR002877; rRNA_MeTrfase_FtsJ_dom.
DR InterPro; IPR011224; rRNA_MeTrfase_M.
DR Pfam; PF01728; FtsJ; 1.
DR PIRSF; PIRSF028774; UCP028774; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Methyltransferase; rRNA processing;
KW S-adenosyl-L-methionine; Transferase.
FT REGION 221 224 S-adenosyl-L-methionine binding (By
FT similarity).
FT ACT_SITE 306 306 Proton acceptor (By similarity).
FT BINDING 188 188 S-adenosyl-L-methionine (By similarity).
FT BINDING 240 240 S-adenosyl-L-methionine (By similarity).
FT BINDING 260 260 S-adenosyl-L-methionine (By similarity).
FT BINDING 277 277 S-adenosyl-L-methionine (By similarity).
SQ SEQUENCE 366 AA; 41994 MW; 5907A3324B21D8B0 CRC64;
MNKVLLYCRS GFEKECAAEI SAKAAERNVY GFPRVKEDAG YVLFECYQQP DAERLIRELP
FETLIFARQM LVVGELLRDL PQDDRISPIV GMLSGVVEKG GELRVEVPDT NEAKELTKFC
RKFTVPLRAS LRESKILLNY ESPKRPVVHV FFIAPGTCYV GYSLPENNSP FYMGIPRLKF
PSDAPSRSTL KLEEAFHVFV PADEWDERLA SGMYAVDLGA CPGGWTYQLV QRSMMVYAVD
NGPMAPSLMD TGQVFHERED GFRFRPPRTN ISWLVCDMVE KPARVANLMA DWLVNGWCRE
AIFNLKLPMK KRYEEVTQNL AMIEQRLTEN GINAQIRARQ LYHDREEVTV HIRRIWAAVG
GRRDER
//
