ID   H2AN28_KAZAF            Unreviewed;       815 AA.
AC   H2AN28;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=SET domain-containing protein {ECO:0000259|PROSITE:PS50280};
GN   Name=KAFR0A03430 {ECO:0000313|EMBL:CCF55778.1};
GN   ORFNames=KAFR_0A03430 {ECO:0000313|EMBL:CCF55778.1};
OS   Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS   1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX   NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF55778.1, ECO:0000313|Proteomes:UP000005220};
RN   [1] {ECO:0000313|EMBL:CCF55778.1, ECO:0000313|Proteomes:UP000005220}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC   NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
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DR   EMBL; HE650821; CCF55778.1; -; Genomic_DNA.
DR   RefSeq; XP_003954913.1; XM_003954864.1.
DR   AlphaFoldDB; H2AN28; -.
DR   STRING; 1071382.H2AN28; -.
DR   GeneID; 13886234; -.
DR   KEGG; kaf:KAFR_0A03430; -.
DR   eggNOG; KOG1844; Eukaryota.
DR   HOGENOM; CLU_017047_0_0_1; -.
DR   InParanoid; H2AN28; -.
DR   OrthoDB; 124870at2759; -.
DR   Proteomes; UP000005220; Chromosome 1.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd15550; PHD_MLL5; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR46462; UPSET, ISOFORM A; 1.
DR   PANTHER; PTHR46462:SF3; UPSET, ISOFORM A; 1.
DR   Pfam; PF20826; PHD_5; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005220};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          431..561
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          146..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          311..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   815 AA;  93032 MW;  03130BB78ABFF237 CRC64;
     MTESNEISTR DTQKPLQQAH NQSLLDDAST LLLFSQGNRR ESQQPSKPTV HPTTNRSPIN
     TTNLPPPPVL QPMTRPSFSG TTVLDPMGRP MLTMPNTAAA IMTVPTDTPT TRRKSSLQSN
     ILPPVSNFNS VQSASQSVMN QDMLQHQFAS RSESIPSSSI GNTPPKSRSR SITNKDTSAI
     AAAAAALATA ANIPLPLRKH ELEVTQKKEE IEENDEEHEE HPKKKSKTAK DHEWPIPDSY
     VVDQDSGIIT CICEFNDDDG FTVQCEHCNR WQHAICYGIE RVEDVPDLYL CNACNPRKLD
     IKHAKMIQKN RKENDLIHKQ ENEYNQAQNN RRRRKTESTN EHDNKSTETQ NDISTKTDNK
     DGSNDRDSNL PPDNNIYKKK EHMLTASDAY AAVYLSLNEL KYKDKYVKLF LENHINDDCV
     IPYKENEFSS IPIDISTSSD ASYLRSFPGF SKLGIAIQQD CNKNDLICEL LGELDFQRNY
     ITNPRNHYRI WGTTKRKVFF HPDWPLVLDE RLCGNLTRYL RRSCYPNVEL VTIRLKDNSI
     KFVLRALQDL EKGDELHIGW NWDFTHPILQ LIKGNMNFDA LDDNMKFTLI HSVDTILGSC
     ECACGNNSKD CHLLKVKKLS TNLYKSVKSK MNNRFKLNEI LNHYQSKRNK RPEPILDCLV
     KQANERESKD IPHPPSIDES IRMGEKKNEG VLEHDIQASS PSSPPKNNTQ PFKLKLYENY
     HTSFKTIDSL QSTASKIPSE YDESDCTELD KLAIPIPFPL PMDINDKSPK AVENSEQLNE
     SKTLELSDKI NKVEEHSQNI KKKLSFADYR KKQHK
//