GenomeNet

Database: UniProt/TrEMBL
Entry: H2ANJ1_KAZAF
LinkDB: H2ANJ1_KAZAF
Original site: H2ANJ1_KAZAF 
ID   H2ANJ1_KAZAF            Unreviewed;       948 AA.
AC   H2ANJ1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 35.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=KAFR0A05050 {ECO:0000313|EMBL:CCF55941.1};
GN   ORFNames=KAFR_0A05050 {ECO:0000313|EMBL:CCF55941.1};
OS   Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 /
OS   CECT 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces
OS   africanus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX   NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF55941.1, ECO:0000313|Proteomes:UP000005220};
RN   [1] {ECO:0000313|EMBL:CCF55941.1, ECO:0000313|Proteomes:UP000005220}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC   NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S.,
RA   Byrne K.P., Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type
RT   switching accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; HE650821; CCF55941.1; -; Genomic_DNA.
DR   RefSeq; XP_003955076.1; XM_003955027.1.
DR   ProteinModelPortal; H2ANJ1; -.
DR   EnsemblFungi; CCF55941; CCF55941; KAFR_0A05050.
DR   GeneID; 13886058; -.
DR   KEGG; kaf:KAFR_0A05050; -.
DR   InParanoid; H2ANJ1; -.
DR   KO; K10777; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000005220; Chromosome 1.
DR   GO; GO:0032807; C:DNA ligase IV complex; IEA:EnsemblFungi.
DR   GO; GO:0000790; C:nuclear chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:EnsemblFungi.
DR   GO; GO:0001302; P:replicative cell aging; IEA:EnsemblFungi.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 2.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF50249; SSF50249; 2.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005220};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005220}.
FT   DOMAIN      370    498       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      684    783       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      870    947       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   948 AA;  110462 MW;  120A49CD94E7200D CRC64;
     MDLTVPEVEV PRNFAPSPQF KWLCEELFSK LEEVPNQRHL TTKRITLRYY EIITNFVNLW
     RTTVGDDIYP ALILALPYRD RRMYNVKDYT LIKAICTYLK LPKNSFTEKR LLNWKQRADR
     SVKLSVSCVN EMRKRKSEPV EKSPITLDEL NTLLDFLSQD RNIKGRGYKN LSESSIFTYC
     IEKMSFMELR YFFDIILKAR VIGPHEHKLL NAWHPDAEDY LSVVSDLKTV CTRLWNPNIR
     LRHDELSINI GYAFAPHLAK KLSISYDKIC KKLKNDFFIE EKMDGERIQI HYMDYGNDIK
     FLSRRGVDYT YLYGENLSTG TIACYLKLNR DVKECVLDGE MVTYDEDQDI LLPFGMVKSA
     AMNALTKEEI SGQDYHPLLM VFDLVFLNGS SLVEFPLYQR KDYLASVLEP YRARVQIVNF
     TRCSNENIIR KSLEHAISVG SEGIVLKNYN SRYMIGSRND SWIKIKPEYL EQFGENMDLI
     VIGRDSAKKD SFYCGLTVLD EEEEKLVEEI DKGVVNLVSD ESDYENPENN RHIKKVVSFC
     MIANGISQNE YKEIYRKTRG FWKKTEEVPP PPELIEFGTQ VPMEWIEPEH SVVLEIKARS
     LDNTESSCKR FKAGCTLYGG YCRRIRDDVD WKSSFSLAEL RRDRRIKHYP GTSEKDTLLK
     SKKRRKKQLL TPLNQNLNPR DIQTTSKIFD GLFFYILSDY FDTNENVRIS KDDLQKLLLE
     NGGKISHNIV SKRESKSNLR ILCGKYTAEC NVLIKRGYDI LSPQWVIDCV ENKKIVKIEP
     SHCFSVSDDL MALAMRRVDK YGDSYESLLS VSRLSYILRS SKDISPDLLS PANMSLDFEK
     VPYFLFWRRK AFVMEHNFDK SSIRETILKI QLYGGKVVKN ISECNIVIFP KAEITVIRES
     MKFIRNTLAK TVSTSVELPM LPRIVSFEWI DASIEKNVQV PEEDYVPM
//
DBGET integrated database retrieval system