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Database: UniProt/TrEMBL
Entry: H2AR48_KAZAF
LinkDB: H2AR48_KAZAF
Original site: H2AR48_KAZAF 
ID   H2AR48_KAZAF            Unreviewed;       514 AA.
AC   H2AR48;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=alanine transaminase {ECO:0000256|ARBA:ARBA00026106};
DE            EC=2.6.1.2 {ECO:0000256|ARBA:ARBA00026106};
GN   Name=KAFR0B05530 {ECO:0000313|EMBL:CCF56848.1};
GN   ORFNames=KAFR_0B05530 {ECO:0000313|EMBL:CCF56848.1};
OS   Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS   1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX   NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF56848.1, ECO:0000313|Proteomes:UP000005220};
RN   [1] {ECO:0000313|EMBL:CCF56848.1, ECO:0000313|Proteomes:UP000005220}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC   NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- PATHWAY: Amino-acid degradation; L-alanine degradation via transaminase
CC       pathway; pyruvate from L-alanine: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00025708}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC       aminotransferase family. Alanine aminotransferase subfamily.
CC       {ECO:0000256|ARBA:ARBA00025785}.
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DR   EMBL; HE650822; CCF56848.1; -; Genomic_DNA.
DR   RefSeq; XP_003955983.1; XM_003955934.1.
DR   AlphaFoldDB; H2AR48; -.
DR   STRING; 1071382.H2AR48; -.
DR   GeneID; 13884730; -.
DR   KEGG; kaf:KAFR_0B05530; -.
DR   eggNOG; KOG0258; Eukaryota.
DR   HOGENOM; CLU_014254_3_0_1; -.
DR   InParanoid; H2AR48; -.
DR   OrthoDB; 5472891at2759; -.
DR   UniPathway; UPA00528; UER00586.
DR   Proteomes; UP000005220; Chromosome 2.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0008483; F:transaminase activity; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00609; AAT_like; 1.
DR   Gene3D; 1.10.287.1970; -; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR045088; ALAT1/2-like.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11751; ALANINE AMINOTRANSFERASE; 1.
DR   PANTHER; PTHR11751:SF29; AT04676P; 1.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005220};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          133..494
FT                   /note="Aminotransferase class I/classII"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
SQ   SEQUENCE   514 AA;  57405 MW;  D099A04495D1382F CRC64;
     MQLTEEFAAT TQYFPVRKAL DDDTIHNFKP AKKITLDDLN QNVLKSEYAV RGSIPRRAEE
     LEFELLNNDS SDSLAFENIV HANIGNPQQL DQKPLTFSRQ VISILQYPEL LNQRNILVST
     GIFKSDAMER AETLLCHIGG SVGAYSSSQG VYGIRETVAN YITARDNGET ASPDDIFLTE
     GASKAASYLL SLLCKDKNTG VLIPIPQYPL YTATITLCDA KMLPYYLNEE SGWSTNTNEI
     EKVVLDAIAD NVKPSVMVVI NPGNPTGSVL SKDDIIHIIN IGAKYGIVLI ADEVYQENIF
     DGEFHSMKKV LRSLQKQYPG KYDAVQLASL HSTSKGVSGE CGQRGGYMEL VGFKDEIRQA
     ILKLASISLC SVITGQALVD LMVNPPKKGD ESYELDNFER KNIHETLKER AEKLYNLFCQ
     LKGVECQKPQ GAMYLFPKLH FPQTLITEAI NQNMSPDEFY CHALLEATGI CTVPGSGFGQ
     KEGTYHLRTT FLAPGNQWTE KWKLFHEEFF SKYQ
//
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