ID H2FQC7_CORPS Unreviewed; 206 AA.
AC H2FQC7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 03-APR-2013, entry version 10.
DE RecName: Full=Thymidylate kinase;
DE EC=2.7.4.9;
DE AltName: Full=dTMP kinase;
GN Name=tmk; ORFNames=Cp3995_0522;
OS Corynebacterium pseudotuberculosis 3/99-5.
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1087452;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=3/99-5;
RX PubMed=22887652; DOI=10.1128/JB.00918-12;
RA Pethick F.E., Lainson A.F., Yaga R., Flockhart A., Smith D.G.,
RA Donachie W., Cerdeira L.T., Silva A., Bol E., Lopes T.S.,
RA Barbosa M.S., Pinto A.C., Dos Santos A.R., Soares S.C., Almeida S.S.,
RA Guimaraes L.C., Aburjaile F.F., Abreu V.A., Ribeiro D., Fiaux K.K.,
RA Diniz C.A., Barbosa E.G., Pereira U.P., Hassan S.S., Ali A.,
RA Bakhtiar S.M., Dorella F.A., Carneiro A.R., Ramos R.T., Rocha F.S.,
RA Schneider M.P., Miyoshi A., Azevedo V., Fontaine M.C.;
RT "Complete Genome Sequences of Corynebacterium pseudotuberculosis
RT Strains 3/99-5 and 42/02-A, Isolated from Sheep in Scotland and
RT Australia, Respectively.";
RL J. Bacteriol. 194:4736-4737(2012).
CC -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC salvage pathways of dTTP synthesis (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
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DR EMBL; CP003152; AEX38991.1; -; Genomic_DNA.
DR RefSeq; YP_005122640.1; NC_016781.1.
DR EnsemblBacteria; AEX38991; AEX38991; Cp3995_0522.
DR GeneID; 11675592; -.
DR KEGG; cpl:Cp3995_0522; -.
DR KO; K00943; -.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:HAMAP.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00165; Thymidylate_kinase; 1; -.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR PANTHER; PTHR10344; PTHR10344; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide biosynthesis; Nucleotide-binding;
KW Transferase.
SQ SEQUENCE 206 AA; 23068 MW; B8A9588B2C77D947 CRC64;
MIIAIEGIDG AGKNTLVRAL VEKLDARVLG FPRYQDSIHA HLAQKALYQE MGDVSDSIYA
MALLFALDRR EIAEELRSYK GSEDVILLDR YVSSNAAYSA ARAQDWNLVA WVSHLEFEEF
GLPTPDIQVL LNTSPEVAAQ RAAKREEQDQ DRSRDCYETD SSLQVRTSDA YARLAEEKRF
SPWIVAQPGD SVDDVALKII QTLGTM
//
