ID H2IN07_9VIBR Unreviewed; 298 AA.
AC H2IN07;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 01-MAY-2013, entry version 9.
DE RecName: Full=Inosose dehydratase;
DE EC=4.2.1.44;
DE AltName: Full=2-keto-myo-inositol dehydratase;
GN Name=iolE; ORFNames=VEJY3_21341;
OS Vibrio sp. EJY3.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC Vibrionaceae; Vibrio.
OX NCBI_TaxID=1116375;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EJY3;
RX PubMed=22535948; DOI=10.1128/JB.00303-12;
RA Roh H., Yun E.J., Lee S., Ko H.J., Kim S., Kim B.Y., Song H.,
RA Lim K.I., Kim K.H., Choi I.G.;
RT "Genome Sequence of Vibrio sp. Strain EJY3, an Agarolytic Marine
RT Bacterium Metabolizing 3,6-Anhydro-L-Galactose as a Sole Carbon
RT Source.";
RL J. Bacteriol. 194:2773-2774(2012).
CC -!- FUNCTION: Catalyzes the dehydration of inosose (2-keto-myo-
CC inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-
CC (3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-
CC inositol) (By similarity).
CC -!- CATALYTIC ACTIVITY: 2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-
CC trihydroxycyclohexa-1,2-dione + H(2)O.
CC -!- COFACTOR: Cobalt or manganese (By similarity).
CC -!- COFACTOR: Glutathione (By similarity).
CC -!- SIMILARITY: Belongs to the IolE/MocC family.
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DR EMBL; CP003242; AEX24683.1; -; Genomic_DNA.
DR RefSeq; YP_005025658.1; NC_016614.1.
DR EnsemblBacteria; AEX24683; AEX24683; VEJY3_21341.
DR GeneID; 11669141; -.
DR KEGG; vej:VEJY3_21341; -.
DR KO; K03335; -.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0030145; F:manganese ion binding; IEA:HAMAP.
DR GO; GO:0050114; F:myo-inosose-2 dehydratase activity; IEA:HAMAP.
DR GO; GO:0019310; P:inositol catabolic process; IEA:HAMAP.
DR Gene3D; 3.20.20.150; -; 1.
DR HAMAP; MF_01672; IolE; 1; -.
DR InterPro; IPR023952; IolE.
DR InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR Pfam; PF01261; AP_endonuc_2; 1.
DR SUPFAM; SSF51658; Xyl_isomerase-like_TIM-brl; 1.
PE 3: Inferred from homology;
KW Cobalt; Isomerase; Lyase; Manganese.
SQ SEQUENCE 298 AA; 33091 MW; 4E92AF992109409A CRC64;
MDKNKVKLGI APIAWTNDDL PSLGGDNTFE QCVSEMALAG FTGSEVGNKY PKDTAVLKEK
LDLRGIQICN AWFSTFFADG KEDETITGFL SHMNFLHEMG AKVIGCSEQS GSIQGTDKAV
FDEKPSFNEE QWKKVASGYN QLSELAAEKG MKVCLHHHMG TAIQTPEEID KFMGITDQSV
GLLLDTGHIY YSEGSQQAII NVLTKYVDRI PHVHLKDIRD EKRHQVIDEH RSFLDGVRLG
AFTVPGDGVI DFAPVFEILD KSGYEGWMVV EAEQDPATAD PLEYALKARQ YIKDIANI
//
