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Database: UniProt/TrEMBL
Entry: H2IN07_9VIBR
LinkDB: H2IN07_9VIBR
Original site: H2IN07_9VIBR 
ID   H2IN07_9VIBR            Unreviewed;       298 AA.
AC   H2IN07;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   26-NOV-2014, entry version 17.
DE   RecName: Full=Inosose dehydratase {ECO:0000256|HAMAP-Rule:MF_01672};
DE            EC=4.2.1.44 {ECO:0000256|HAMAP-Rule:MF_01672};
DE   AltName: Full=2-keto-myo-inositol dehydratase {ECO:0000256|HAMAP-Rule:MF_01672};
GN   Name=iolE {ECO:0000256|HAMAP-Rule:MF_01672};
GN   ORFNames=VEJY3_21341 {ECO:0000313|EMBL:AEX24683.1};
OS   Vibrio sp. EJY3.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Vibrio.
OX   NCBI_TaxID=1116375 {ECO:0000313|EMBL:AEX24683.1, ECO:0000313|Proteomes:UP000006799};
RN   [1] {ECO:0000313|EMBL:AEX24683.1, ECO:0000313|Proteomes:UP000006799}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EJY3 {ECO:0000313|EMBL:AEX24683.1};
RX   PubMed=22535948; DOI=10.1128/JB.00303-12;
RA   Roh H., Yun E.J., Lee S., Ko H.J., Kim S., Kim B.Y., Song H.,
RA   Lim K.I., Kim K.H., Choi I.G.;
RT   "Genome Sequence of Vibrio sp. Strain EJY3, an Agarolytic Marine
RT   Bacterium Metabolizing 3,6-Anhydro-L-Galactose as a Sole Carbon
RT   Source.";
RL   J. Bacteriol. 194:2773-2774(2012).
CC   -!- FUNCTION: Catalyzes the dehydration of inosose (2-keto-myo-
CC       inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-
CC       (3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-
CC       inositol). {ECO:0000256|HAMAP-Rule:MF_01672}.
CC   -!- CATALYTIC ACTIVITY: 2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-
CC       trihydroxycyclohexa-1,2-dione + H(2)O. {ECO:0000256|HAMAP-
CC       Rule:MF_01672}.
CC   -!- COFACTOR:
CC       Note=Cobalt or manganese. {ECO:0000256|HAMAP-Rule:MF_01672};
CC   -!- COFACTOR:
CC       Note=Glutathione. {ECO:0000256|HAMAP-Rule:MF_01672};
CC   -!- SIMILARITY: Belongs to the IolE/MocC family. {ECO:0000256|HAMAP-
CC       Rule:MF_01672}.
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DR   EMBL; CP003242; AEX24683.1; -; Genomic_DNA.
DR   RefSeq; WP_014234525.1; NC_016614.1.
DR   RefSeq; YP_005025658.1; NC_016614.1.
DR   ProteinModelPortal; H2IN07; -.
DR   EnsemblBacteria; AEX24683; AEX24683; VEJY3_21341.
DR   GeneID; 11669141; -.
DR   KEGG; vej:VEJY3_21341; -.
DR   KO; K03335; -.
DR   BioCyc; VSP1116375:GJV8-4336-MONOMER; -.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR   GO; GO:0050114; F:myo-inosose-2 dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.150; -; 1.
DR   HAMAP; MF_01672; IolE; 1.
DR   InterPro; IPR023952; IolE.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
PE   3: Inferred from homology;
KW   Cobalt {ECO:0000256|HAMAP-Rule:MF_01672};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006799};
KW   Isomerase {ECO:0000313|EMBL:AEX24683.1};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_01672};
KW   Manganese {ECO:0000256|HAMAP-Rule:MF_01672}.
SQ   SEQUENCE   298 AA;  33091 MW;  4E92AF992109409A CRC64;
     MDKNKVKLGI APIAWTNDDL PSLGGDNTFE QCVSEMALAG FTGSEVGNKY PKDTAVLKEK
     LDLRGIQICN AWFSTFFADG KEDETITGFL SHMNFLHEMG AKVIGCSEQS GSIQGTDKAV
     FDEKPSFNEE QWKKVASGYN QLSELAAEKG MKVCLHHHMG TAIQTPEEID KFMGITDQSV
     GLLLDTGHIY YSEGSQQAII NVLTKYVDRI PHVHLKDIRD EKRHQVIDEH RSFLDGVRLG
     AFTVPGDGVI DFAPVFEILD KSGYEGWMVV EAEQDPATAD PLEYALKARQ YIKDIANI
//
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