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Database: UniProt/TrEMBL
Entry: H2JTF0_STRHJ
LinkDB: H2JTF0_STRHJ
Original site: H2JTF0_STRHJ 
ID   H2JTF0_STRHJ            Unreviewed;       739 AA.
AC   H2JTF0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-SEP-2017, entry version 30.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AEY93026.1};
GN   OrderedLocusNames=SHJG_7759 {ECO:0000313|EMBL:AEY93026.1};
OS   Streptomyces hygroscopicus subsp. jinggangensis (strain 5008).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1133850 {ECO:0000313|EMBL:AEY93026.1, ECO:0000313|Proteomes:UP000007170};
RN   [1] {ECO:0000313|Proteomes:UP000007170}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5008 {ECO:0000313|Proteomes:UP000007170};
RA   Wu H., Bai L.;
RT   "Genomic analysis of Streptomyces hygroscopicus subsp. jinggangensis
RT   5008.";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP003275; AEY93026.1; -; Genomic_DNA.
DR   RefSeq; WP_014676311.1; NC_017765.1.
DR   STRING; 1133850.SHJG_7759; -.
DR   EnsemblBacteria; AEY93026; AEY93026; SHJG_7759.
DR   KEGG; shy:SHJG_7759; -.
DR   PATRIC; fig|1133850.20.peg.8389; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   Proteomes; UP000007170; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007170};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007170}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79582 MW;  9CE1CD667F53E7E0 CRC64;
     MTDSTIIYTY TDEAPALATH SFLPVIQAYA SQAGVPVETR DISLAGRIIA VFPEYLNEDQ
     RIPDALTELG ELAKTPAANI IKLPNISASI PQLKAAVAEL QGKGYALPDY PDDPKTDEER
     EIRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKTHPH RMGAWSGESK TNVATMGEND
     FRSTEKSVVV SEDGALKIEL VGEDGTTTVL KESVPVLAGE VVDASVMRVA ELNSFLAAQV
     ARAKQEGVLF SVHLKATMMK VSDPIIFGHV VRAFFPKTFA RYGETLKAAG LTPNDGLGGI
     LKGLENLPEG AEIKASFEAE IAEGPALAMV DSDKGITNLH VPSDVIIDAS MPAMIRTSGH
     MWGPDGQEHD ALAVIPDSSY AGVYQAVIED CRANGAYDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPAA GTVRLTDQAG NVLIEQPVAQ GDIFRACQTK DDPIRDWVKL AVTRARATGD
     PAVFWLDETR AHDAQLIAKV KQYLPEHDTE GLDIRILSPV EATKLSVERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFFALVP SFEQYAAATG NTRAKVLADT LDRATATFLN EDKSPTRRVG GIDNRGSHFY
     LSLYWAQELA GQTEDADLAK AFAPLAETLA ANEQKIVEEL NAVQGSPADI GGYYQVDKAK
     ADAVMRPSAT WNEALASLS
//
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