GenomeNet

Database: UniProt/TrEMBL
Entry: H2L9G4_ORYLA
LinkDB: H2L9G4_ORYLA
Original site: H2L9G4_ORYLA 
ID   H2L9G4_ORYLA            Unreviewed;       478 AA.
AC   H2L9G4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   07-JUN-2017, entry version 38.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   Name=gck {ECO:0000313|Ensembl:ENSORLP00000002505};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000002505, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000002505}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002505};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672880}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSORLP00000002505}.
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DR   EMBL; BAAF04041569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04041570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04041571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004072203.1; XM_004072155.2.
DR   STRING; 8090.ENSORLP00000002505; -.
DR   Ensembl; ENSORLT00000002506; ENSORLP00000002505; ENSORLG00000002010.
DR   GeneID; 101168372; -.
DR   KEGG; ola:101168372; -.
DR   CTD; 2645; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   eggNOG; COG5026; LUCA.
DR   GeneTree; ENSGT00390000017159; -.
DR   InParanoid; H2L9G4; -.
DR   KO; K12407; -.
DR   OMA; ERQFFRA; -.
DR   OrthoDB; EOG091G08MD; -.
DR   TreeFam; TF314238; -.
DR   Proteomes; UP000001038; Chromosome 9.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   GO; GO:1990798; P:pancreas regeneration; IEA:Ensembl.
DR   GO; GO:0003323; P:type B pancreatic cell development; IEA:Ensembl.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672869}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672871};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transferase {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       28    227       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      233    467       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
FT   COILED       32     59       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   478 AA;  53822 MW;  96F508E62250EDFE CRC64;
     MPCVSTHLDT MGKLPSSFKA VVKEILMVEQ ILSEFRLNKE ELKEVMKRMQ REMDRGLRLE
     SHEEASVKML PTYVCSTPEG SEVGDFLALD LGGTNFRVML VKVGKDEERG FKVETTNQMY
     SIPEDAMTGT AEMLFDYIAE CMSDFLDKHH IKHKKLPLGF TFSFPVRHED IDKGILLNWT
     KGFKASGAEG NNVVGLLRDA IKRRGDFEMD VVAMVNDTVA TMISCYYEDR SCEVGMIVGT
     GCNACYMEEM RTVELVEGEE GRMCVNTEWG AFGDKGELEE FRLEYDRVVD EFSINPGQQL
     FEKLISGKYM GELVRLVLMK LVKENLLFNG EASEQLRTRG SFETRFVSQV ESDSGDRKQI
     YNILSSLGVL PSELDCDIVR LVCESVSTRS AQMCGAGLAG VINRMRERRC EEELKITVGV
     DGSVYKLHPW FRDRFHKVVW DLSPHCEITF IQSEEGSGRG VALISAVACK MAACTTAP
//
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