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Database: UniProt/TrEMBL
Entry: H2NCL4_PONAB
LinkDB: H2NCL4_PONAB
Original site: H2NCL4_PONAB 
ID   H2NCL4_PONAB            Unreviewed;       885 AA.
AC   H2NCL4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   07-JUN-2017, entry version 29.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00903};
DE            EC=2.1.1.43 {ECO:0000256|PROSITE-ProRule:PRU00903};
GN   Name=KMT5B {ECO:0000313|Ensembl:ENSPPYP00000003448};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000003448, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000003448, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000003448}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|PROSITE-ProRule:PRU00903}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000256|PROSITE-
CC       ProRule:PRU00903}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000003448}.
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DR   EMBL; ABGA01071781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01071782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01071783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01071784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01071785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01071786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01071787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01071788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01071789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01071790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_009244341.1; XM_009246066.1.
DR   STRING; 9601.ENSPPYP00000003448; -.
DR   Ensembl; ENSPPYT00000003571; ENSPPYP00000003448; ENSPPYG00000002973.
DR   GeneID; 100450271; -.
DR   KEGG; pon:100450271; -.
DR   CTD; 51111; -.
DR   eggNOG; KOG2589; Eukaryota.
DR   eggNOG; ENOG410XPH8; LUCA.
DR   GeneTree; ENSGT00520000055640; -.
DR   InParanoid; H2NCL4; -.
DR   KO; K11429; -.
DR   OMA; SGCLTRH; -.
DR   OrthoDB; EOG091G0IUY; -.
DR   TreeFam; TF106433; -.
DR   Proteomes; UP000001595; Chromosome 11.
DR   GO; GO:0000780; C:condensed nuclear chromosome, centromeric region; IEA:Ensembl.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:UniProtKB-UniRule.
DR   GO; GO:0034773; P:histone H4-K20 trimethylation; IEA:UniProtKB-UniRule.
DR   InterPro; IPR025790; Hist-Lys_N-MTase_Suvar4-20.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51570; SAM_MT43_SUVAR420_2; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00903};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00903};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU00903}.
FT   DOMAIN      193    308       SET. {ECO:0000259|PROSITE:PS50280}.
SQ   SEQUENCE   885 AA;  99191 MW;  EAC8EEEB4A33C0A3 CRC64;
     MKWLGESKNM VVNGRRNGGK LSNDHQQNQS KLQHTGKDTL KAGKNAVERR SNRCNGNSGF
     EGQSRYVPSS GMSAKELCEN DDLATSLVLD PYLGFQTHKM NTSAFPSRSS RHFSKSDSFS
     HNNPVRFRPI KGRQEELKEV IERFKKDEHL EKAFKCLTSG EWARHYFLNK NKMQEKLFKE
     HVFIYLRMFA TDSGFEILPC NRYSSEQNGA KIVATKEWKR NDKIELLVGC IAELSEIEEN
     MLLRHGENDF SVMYSTRKNC AQLWLGPAAF INHDCRPNCK FVSTGRDTAC VKALRDIEPG
     EEISCYYGDG FFGENNEFCE CYTCERRGTG AFKSRVGLPA PAPVINSKYG LRETDKRLNR
     LKKLGDSSKN SDSQSVSSNT DADTTQEKNN ATSNRKSSVG VKKNSKSRTL TRQSMSRIPA
     SSNSTSSKLT HINNSRVPKK LKKPAKPLLS KIKLRNHCKR LEQKNASRKL EMGNLVLKEP
     KVVLYKNLPI KKDKEPEGPA QAAVASGCLT RHAAREHRQN PVRGAHSQGE SSPCTYITRR
     SVRTRTNLKE ASDIKLEPNT LDGYKSSMTE PCPDSGEQPQ PAPVVQEEEL AHETAQKGEA
     KCHKSDTGMS KKKSRQGKLV KQFAKIEEST PVHDSPGKDD AVPDLMGPHS DQGEHSGTVG
     VPVSYTDCAP SPVGCSVVTS DSFKTKDSFR TAKSKKKRRI TRYDAQLILE NNSGIPKLTL
     RRRHDSSSKT NDQENDGMNS SKISIKLSKD HDNDNNLYVA KLNNGFNSGS GSSSTKLKIQ
     LKRDEENRGS YTEGLHENGV CCSDPLSLLE SRMEVDDYSQ YEEESTDDSS SSEGDEEEDD
     YDDDFEDDFI PLPPAKRLRL IVGKDSIDID ISSRRREDQS LRLNA
//
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