ID H2QM90_PANTR Unreviewed; 717 AA.
AC H2QM90; A0A2J8NPU6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=CCR4-NOT transcription complex subunit 10 {ECO:0000256|ARBA:ARBA00014869, ECO:0000256|RuleBase:RU367083};
GN Name=CNOT10 {ECO:0000313|Ensembl:ENSPTRP00000025390.4,
GN ECO:0000313|VGNC:VGNC:7038};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000025390.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000025390.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000025390.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC cellular mRNA deadenylases and is linked to various cellular processes
CC including bulk mRNA degradation, miRNA-mediated repression,
CC translational repression during translational initiation and general
CC transcription regulation. {ECO:0000256|RuleBase:RU367083}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367083}.
CC Nucleus {ECO:0000256|RuleBase:RU367083}.
CC -!- SIMILARITY: Belongs to the CNOT10 family.
CC {ECO:0000256|ARBA:ARBA00010080, ECO:0000256|RuleBase:RU367083}.
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DR EMBL; AACZ04000207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04000208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001168099.2; XM_001168099.4.
DR AlphaFoldDB; H2QM90; -.
DR Ensembl; ENSPTRT00000027534.4; ENSPTRP00000025390.4; ENSPTRG00000014722.6.
DR GeneID; 470780; -.
DR KEGG; ptr:470780; -.
DR CTD; 25904; -.
DR VGNC; VGNC:7038; CNOT10.
DR eggNOG; KOG2471; Eukaryota.
DR GeneTree; ENSGT00390000001827; -.
DR HOGENOM; CLU_013100_0_0_1; -.
DR OrthoDB; 5482679at2759; -.
DR TreeFam; TF323368; -.
DR Proteomes; UP000002277; Chromosome 3.
DR Bgee; ENSPTRG00000014722; Expressed in testis and 20 other cell types or tissues.
DR GO; GO:0030014; C:CCR4-NOT complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR039740; CNOT10.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12979; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10; 1.
DR PANTHER; PTHR12979:SF5; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|RuleBase:RU367083};
KW Nucleus {ECO:0000256|RuleBase:RU367083};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW RNA-mediated gene silencing {ECO:0000256|RuleBase:RU367083};
KW Transcription {ECO:0000256|RuleBase:RU367083};
KW Transcription regulation {ECO:0000256|RuleBase:RU367083};
KW Translation regulation {ECO:0000256|RuleBase:RU367083}.
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 80..107
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 183..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 717 AA; 79407 MW; 0540ED1B5FB13386 CRC64;
MAADKPADQG AEKHEGTGQS SGITDQEKEL STNAFQAFTS GNYDACLQHL ACLQDINKDD
YKIILNTAVA EFFKSNQTTT DNLRQTLNQL KNQVHSAVEE MDGLDDVENS MLYYNQAVIL
YHLRQYTEAI SVGEKLYQFI EPFEEKFAQA VCFLLVDLYI LTYQAEKALH LLAVLEKMIS
QGNNNKNGKN ETGNNNNKDG SNHKAESGAL IEAAKSKIHQ YKVRAYIQMK SLKACKREIK
SVMNTAGNSA PSLFLKSNFE YLRGNYRKAV KLLNSSNIAE HPGFMKTGEC LRCMFWNNLG
CIHFAMSKHN LGIFYFKKAL QENDNVCAQL SAGSTDPGKK FSGRPMCTLL TNKRYELLYN
CGIQLLHIGR PLAAFECLIE AVQVYHANPR LWLRLAECCI ATNKGTSEQE TKGLPSKKGI
VQSIVGQGYH RKIVLASQSI QNTVYNDGQS SAIPVASMEF AAICLRNALL LLPEEQQDPK
QENGAKNSNQ LGGNTESSES SETCRCSILA CSAYVALALG DNLMALNHAD KLLQQPKLSG
SLKFLGHLYA AEALISLDRI SDAITHLNPE NVTDVSLGIS SNEQDQGSDK GENEAMESSG
KRAPQCYPSS VNSARTVMLF NLGSAYCLRS EYDKARKCLH QAASMIHPKE VPPEAILLAV
YLELQNGNTQ LALQIIKRNQ LLPAVKTHSE VRKKPVFQPV HPIQPIQMPA FTTVQRK
//
