ID H6L130_SAPGL Unreviewed; 182 AA.
AC H6L130;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 03-APR-2013, entry version 9.
DE RecName: Full=Peptide methionine sulfoxide reductase MsrA;
DE Short=Protein-methionine-S-oxide reductase;
DE EC=1.8.4.11;
DE AltName: Full=Peptide-methionine (S)-S-oxide reductase;
GN Name=msrA; OrderedLocusNames=SGRA_3339;
OS Saprospira grandis (strain Lewin).
OC Bacteria; Bacteroidetes; Sphingobacteriia; Sphingobacteriales;
OC Saprospiraceae; Saprospira.
OX NCBI_TaxID=984262;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lewin;
RX DOI=10.4056/sigs.2445005;
RA Saw J., Yuryev A., Kanbe M., Hou S., Young A., Aizawa S., Alam M.;
RT "Complete genome sequencing and analysis of Saprospira grandis str.
RT Lewin, a predatory marine bacterium.";
RL Stand. Genomic Sci. 6:0-0(2012).
CC -!- FUNCTION: Has an important function as a repair enzyme for
CC proteins that have been inactivated by oxidation. Catalyzes the
CC reversible oxidation-reduction of methionine sulfoxide in proteins
CC to methionine (By similarity).
CC -!- CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H(2)O =
CC L-methionine (S)-S-oxide + thioredoxin.
CC -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CC -!- SIMILARITY: Belongs to the MsrA Met sulfoxide reductase family.
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DR EMBL; CP002831; AFC26066.1; -; Genomic_DNA.
DR RefSeq; YP_005323650.1; NC_016940.1.
DR ProteinModelPortal; H6L130; -.
DR EnsemblBacteria; AFC26066; AFC26066; SGRA_3339.
DR GeneID; 11924010; -.
DR KEGG; sgn:SGRA_3339; -.
DR KO; K07304; -.
DR GO; GO:0008113; F:peptide-methionine (S)-S-oxide reductase activity; IEA:HAMAP.
DR GO; GO:0006464; P:cellular protein modification process; IEA:HAMAP.
DR Gene3D; 3.30.1060.10; -; 1.
DR HAMAP; MF_01401; MsrA; 1; -.
DR InterPro; IPR002569; Met_Sox_Rdtase_MsrA.
DR Pfam; PF01625; PMSR; 1.
DR SUPFAM; SSF55068; MsrA; 1.
DR TIGRFAMs; TIGR00401; msrA; 1.
PE 3: Inferred from homology;
KW Complete proteome; Oxidoreductase.
FT ACT_SITE 13 13 By similarity.
SQ SEQUENCE 182 AA; 20359 MW; C2B8E472B60657CE CRC64;
MEGLAVATLG AGCFWCVEAI FQDLKGVKKV VSGYAGGQVE NPTYKAVCAG TTGHAEVVQV
TFDPEVLSYA DLLEVFFFTH NPTTLNRQGN DVGTQYRSAI FYHSEEQKAV AQKVKAKMAS
EFADPIVTEI VAFDRFYAAE DYHQDYYNLN ANKNPYCSAV ISPKVNKFRK NYKDKLKEEL
KK
//
