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Database: UniProt/TrEMBL
Entry: H6P0T5_SALTI
LinkDB: H6P0T5_SALTI
Original site: H6P0T5_SALTI 
ID   H6P0T5_SALTI            Unreviewed;       456 AA.
AC   H6P0T5;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   04-FEB-2015, entry version 21.
DE   RecName: Full=Adenylosuccinate lyase {ECO:0000256|RuleBase:RU361172};
DE            Short=ASL {ECO:0000256|RuleBase:RU361172};
DE            EC=4.3.2.2 {ECO:0000256|RuleBase:RU361172};
DE   AltName: Full=Adenylosuccinase {ECO:0000256|RuleBase:RU361172};
GN   ORFNames=STBHUCCB_17940 {ECO:0000313|EMBL:AEZ45487.1};
OS   Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=1132507 {ECO:0000313|EMBL:AEZ45487.1, ECO:0000313|Proteomes:UP000007169};
RN   [1] {ECO:0000313|EMBL:AEZ45487.1, ECO:0000313|Proteomes:UP000007169}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P-stx-12 {ECO:0000313|EMBL:AEZ45487.1};
RX   PubMed=22461552; DOI=10.1128/JB.00121-12;
RA   Ong S.Y., Pratap C.B., Wan X., Hou S., Abdul Rahman A.Y., Saito J.A.,
RA   Nath G., Alam M.;
RT   "Complete Genome Sequence of Salmonella enterica subsp. enterica
RT   Serovar Typhi P-stx-12.";
RL   J. Bacteriol. 194:2115-2116(2012).
CC   -!- CATALYTIC ACTIVITY: (S)-2-(5-amino-1-(5-phospho-D-
CC       ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-
CC       (5-phospho-D-ribosyl)imidazole-4-carboxamide.
CC       {ECO:0000256|RuleBase:RU361172}.
CC   -!- CATALYTIC ACTIVITY: N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.
CC       {ECO:0000256|RuleBase:RU361172}.
CC   -!- PATHWAY: Purine metabolism; AMP biosynthesis via de novo pathway;
CC       AMP from IMP: step 2/2. {ECO:0000256|RuleBase:RU361172}.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.
CC       {ECO:0000256|RuleBase:RU361172}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Adenylosuccinate lyase
CC       subfamily. {ECO:0000256|RuleBase:RU361172}.
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DR   EMBL; CP003278; AEZ45487.1; -; Genomic_DNA.
DR   RefSeq; YP_005217340.1; NC_016832.1.
DR   ProteinModelPortal; H6P0T5; -.
DR   SMR; H6P0T5; 1-456.
DR   EnsemblBacteria; AEZ45487; AEZ45487; STBHUCCB_17940.
DR   OMA; DKNWEVL; -.
DR   BioCyc; SENT1132507:GKDO-1780-MONOMER; -.
DR   UniPathway; UPA00074; UER00132.
DR   UniPathway; UPA00075; UER00336.
DR   Proteomes; UP000007169; Chromosome.
DR   GO; GO:0070626; F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004018; F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; IEA:UniProtKB-EC.
DR   GO; GO:0044208; P:'de novo' AMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.275.10; -; 1.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   InterPro; IPR004769; Pur_lyase.
DR   InterPro; IPR013539; PurB_C.
DR   PANTHER; PTHR11444; PTHR11444; 1.
DR   Pfam; PF08328; ASL_C; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00928; purB; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007169};
KW   Lyase {ECO:0000256|RuleBase:RU361172, ECO:0000313|EMBL:AEZ45487.1};
KW   Purine biosynthesis {ECO:0000256|RuleBase:RU361172}.
SQ   SEQUENCE   456 AA;  51498 MW;  E02D6996812D0E46 CRC64;
     MELSSLTAVS PVDGRYGDKV SALRGIFSEY GLLKFRVQVE VRWLQKLAAH AAIKEVPAFA
     ADANGYLDTL VANFNEEDAA RIKTIERTTN HDVKAVEYFL KEKAAAIPAL HDVSEFIHFA
     CTSEDINNLS HALMLKTARD EVILPYWRQV INAVKDLATQ YRDIPLLSRT HGQPATPSTL
     GKEMANVAYR MERQFRQLNQ VEILGKINGA VGNYNAHIAA YPEVDWHQFS EEFVTSLGIQ
     WNPYTTQIEP HDYIAELFDC IARFNTILID FDRDVWGYIA LNHFKQKTIA GEIGSSTMPH
     KVNPIDFENS EGNLGLSNAV LHHLANKLPV SRWQRDLTDS TVLRNLGVGI GYALIAYQST
     LKGVSKLEVN RDHLLDELDH NWEVLAEPIQ TVMRRYGIEK PYEKLKELTR GKRVDAEGMK
     QLIDSLALPE AEKTRLKAMT PANYIGRAVN LVDELK
//
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