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Database: UniProt/TrEMBL
Entry: H6R058_NOCCG
LinkDB: H6R058_NOCCG
Original site: H6R058_NOCCG 
ID   H6R058_NOCCG            Unreviewed;       960 AA.
AC   H6R058;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   28-MAR-2018, entry version 37.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00946768};
DE            Short=PEPC {ECO:0000256|HAMAP-Rule:MF_00595};
DE            Short=PEPCase {ECO:0000256|HAMAP-Rule:MF_00595};
DE            EC=4.1.1.31 {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00946768};
GN   Name=ppc {ECO:0000256|HAMAP-Rule:MF_00595,
GN   ECO:0000313|EMBL:CCF62921.1};
GN   OrderedLocusNames=NOCYR_2139 {ECO:0000313|EMBL:CCF62921.1};
OS   Nocardia cyriacigeorgica (strain GUH-2).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF62921.1, ECO:0000313|Proteomes:UP000008190};
RN   [1] {ECO:0000313|EMBL:CCF62921.1, ECO:0000313|Proteomes:UP000008190}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GUH-2 {ECO:0000313|EMBL:CCF62921.1,
RC   ECO:0000313|Proteomes:UP000008190};
RX   PubMed=22461543; DOI=10.1128/JB.00161-12;
RA   Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA   Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA   Nazaret S., Neto M., Petit S., Roche D., Vallenet D.,
RA   Rodriguez-Nava V., Richard Y., Cournoyer B., Blaha D.;
RT   "Genome Sequence of the Human- and Animal-Pathogenic Strain Nocardia
RT   cyriacigeorgica GUH-2.";
RL   J. Bacteriol. 194:2098-2099(2012).
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid
CC       source for the tricarboxylic acid cycle. {ECO:0000256|HAMAP-
CC       Rule:MF_00595}.
CC   -!- CATALYTIC ACTIVITY: Phosphate + oxaloacetate = H(2)O +
CC       phosphoenolpyruvate + HCO(3)(-). {ECO:0000256|HAMAP-Rule:MF_00595,
CC       ECO:0000256|SAAS:SAAS00946751}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00595, ECO:0000256|SAAS:SAAS00946766};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00595}.
CC   -!- SIMILARITY: Belongs to the PEPCase type 1 family.
CC       {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00946753}.
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DR   EMBL; FO082843; CCF62921.1; -; Genomic_DNA.
DR   STRING; 1127134.NOCYR_2139; -.
DR   EnsemblBacteria; CCF62921; CCF62921; NOCYR_2139.
DR   KEGG; ncy:NOCYR_2139; -.
DR   eggNOG; ENOG4105CCA; Bacteria.
DR   eggNOG; COG2352; LUCA.
DR   KO; K01595; -.
DR   OMA; PWVFGWT; -.
DR   OrthoDB; POG091H040O; -.
DR   Proteomes; UP000008190; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   HAMAP; MF_00595; PEPcase_type1; 1.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR022805; PEP_COase_bac/pln-type.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   PANTHER; PTHR30523; PTHR30523; 1.
DR   Pfam; PF00311; PEPcase; 1.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; SSF51621; 2.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation {ECO:0000256|HAMAP-Rule:MF_00595,
KW   ECO:0000256|SAAS:SAAS00946757};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008190};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00595,
KW   ECO:0000256|SAAS:SAAS00946754};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00595,
KW   ECO:0000256|SAAS:SAAS00946750};
KW   Pyruvate {ECO:0000313|EMBL:CCF62921.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008190}.
FT   ACT_SITE    160    160       {ECO:0000256|HAMAP-Rule:MF_00595,
FT                                ECO:0000256|PROSITE-ProRule:PRU10111}.
FT   ACT_SITE    622    622       {ECO:0000256|HAMAP-Rule:MF_00595,
FT                                ECO:0000256|PROSITE-ProRule:PRU10112}.
SQ   SEQUENCE   960 AA;  104997 MW;  B6F713534C8C6868 CRC64;
     MFGNLRQYCR NMTEPRIETE QDATRPLRED IRFLGGVLGD TIRDHEGPEV FDLIERVRVE
     AFRVRREEVG RSAVADMLDG VDITVALPLI RAFSYFVLLA NLAEDLQRDR RREAHEAAGE
     PPQDSSLAAT YRKLDAAALP EAKVAELLTD ALVSPVITAH PTETRRRTVF DVQTKITELM
     RRRRHYPERD RAGLELEIRR QVLTLWRTAL IRLARLRIQD EIAVGLRYYE LTLFDVIPAI
     NAEVRAALRS RWPDADLLPR PILRPGSWIG GDRDGNPYVT AEVVRTAAGQ AAGVAFGRYL
     RDLVELEKTL SQSGRLVQVS ATVAELAAAG YADPNVHADE PYRRALHRIR ERLTTTAEQA
     LGVPIRSTGA PALGAAAELG ATPIPAVPAL GAPDTTTATP APAYPGPQAL LDDLDAIDAS
     LRDSGDGLLA DDRLAALRHA VETFGFHLQG LDMRQNSEVH EQVVAELLAW AGVHPDYASL
     PEPERVRILS TELSTRRPLL GPHARLSELA AKELGIVRAA ADVVATFGEP AIPNYIISMC
     TSVSDMLEAA LLLKEGGLLD PGAPDGSPSC AAGIVPLFET IEDLGAGAAT LAAVLEVPVY
     RELVAAKGMR QEVMLGYSDS NKDGGYLAAN WALYRAELDL VEVARKTGIR LRLFHGRGGT
     VGRGGGRSYD AILAQPAGAV HGSLRLTEQG EVIAAKYAES GSAHRNLESL IAGTLESTLL
     DMEGLGADAE PSYQLMDELA ARARAAYARL VHETPGFVEY FRQSTPVAEV GDLNIGSRPA
     SRKPTNSVAD LRAIPWVMSW SQARVMLPGW YGTGTALEEW VDDDPQRLAT LADLYRRWPF
     FRTVLSNLAQ VMAKSDLAIA ARYAELVEDT ALREHIFGMI RDEHARTIRM HAAITGNDHL
     LSDNPSLAES IRNRFPYLEP LNQMQVELLR RLRAGDDSEL VKRGILLTMN GLATALRNSG
//
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