ID H6R058_NOCCG Unreviewed; 960 AA.
AC H6R058;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|ARBA:ARBA00022419, ECO:0000256|HAMAP-Rule:MF_00595};
DE Short=PEPC {ECO:0000256|HAMAP-Rule:MF_00595};
DE Short=PEPCase {ECO:0000256|HAMAP-Rule:MF_00595};
DE EC=4.1.1.31 {ECO:0000256|ARBA:ARBA00012305, ECO:0000256|HAMAP-Rule:MF_00595};
GN Name=ppc {ECO:0000256|HAMAP-Rule:MF_00595,
GN ECO:0000313|EMBL:CCF62921.1};
GN OrderedLocusNames=NOCYR_2139 {ECO:0000313|EMBL:CCF62921.1};
OS Nocardia cyriacigeorgica (strain GUH-2).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF62921.1, ECO:0000313|Proteomes:UP000008190};
RN [1] {ECO:0000313|EMBL:CCF62921.1, ECO:0000313|Proteomes:UP000008190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GUH-2 {ECO:0000313|EMBL:CCF62921.1,
RC ECO:0000313|Proteomes:UP000008190};
RX PubMed=22461543; DOI=10.1128/JB.00161-12;
RA Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V.,
RA Richard Y., Cournoyer B., Blaha D.;
RT "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT cyriacigeorgica GUH-2.";
RL J. Bacteriol. 194:2098-2099(2012).
CC -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid source
CC for the tricarboxylic acid cycle. {ECO:0000256|ARBA:ARBA00003670,
CC ECO:0000256|HAMAP-Rule:MF_00595}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=oxaloacetate + phosphate = hydrogencarbonate +
CC phosphoenolpyruvate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC Evidence={ECO:0000256|ARBA:ARBA00001071, ECO:0000256|HAMAP-
CC Rule:MF_00595};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946,
CC ECO:0000256|HAMAP-Rule:MF_00595};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00595}.
CC -!- SIMILARITY: Belongs to the PEPCase type 1 family.
CC {ECO:0000256|ARBA:ARBA00008346, ECO:0000256|HAMAP-Rule:MF_00595}.
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DR EMBL; FO082843; CCF62921.1; -; Genomic_DNA.
DR AlphaFoldDB; H6R058; -.
DR STRING; 1127134.NOCYR_2139; -.
DR KEGG; ncy:NOCYR_2139; -.
DR eggNOG; COG2352; Bacteria.
DR HOGENOM; CLU_006557_2_0_11; -.
DR OMA; PWVFGWT; -.
DR Proteomes; UP000008190; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR Gene3D; 1.20.1440.90; Phosphoenolpyruvate/pyruvate domain; 1.
DR HAMAP; MF_00595; PEPcase_type1; 1.
DR InterPro; IPR021135; PEP_COase.
DR InterPro; IPR022805; PEP_COase_bac/pln-type.
DR InterPro; IPR018129; PEP_COase_Lys_AS.
DR InterPro; IPR033129; PEPCASE_His_AS.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR PANTHER; PTHR30523; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR PANTHER; PTHR30523:SF6; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR Pfam; PF00311; PEPcase; 1.
DR PRINTS; PR00150; PEPCARBXLASE.
DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR PROSITE; PS00781; PEPCASE_1; 1.
DR PROSITE; PS00393; PEPCASE_2; 1.
PE 3: Inferred from homology;
KW Carbon dioxide fixation {ECO:0000256|ARBA:ARBA00023300, ECO:0000256|HAMAP-
KW Rule:MF_00595};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00595};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_00595};
KW Pyruvate {ECO:0000313|EMBL:CCF62921.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008190}.
FT ACT_SITE 160
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00595,
FT ECO:0000256|PROSITE-ProRule:PRU10111"
FT ACT_SITE 622
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00595,
FT ECO:0000256|PROSITE-ProRule:PRU10112"
SQ SEQUENCE 960 AA; 104997 MW; B6F713534C8C6868 CRC64;
MFGNLRQYCR NMTEPRIETE QDATRPLRED IRFLGGVLGD TIRDHEGPEV FDLIERVRVE
AFRVRREEVG RSAVADMLDG VDITVALPLI RAFSYFVLLA NLAEDLQRDR RREAHEAAGE
PPQDSSLAAT YRKLDAAALP EAKVAELLTD ALVSPVITAH PTETRRRTVF DVQTKITELM
RRRRHYPERD RAGLELEIRR QVLTLWRTAL IRLARLRIQD EIAVGLRYYE LTLFDVIPAI
NAEVRAALRS RWPDADLLPR PILRPGSWIG GDRDGNPYVT AEVVRTAAGQ AAGVAFGRYL
RDLVELEKTL SQSGRLVQVS ATVAELAAAG YADPNVHADE PYRRALHRIR ERLTTTAEQA
LGVPIRSTGA PALGAAAELG ATPIPAVPAL GAPDTTTATP APAYPGPQAL LDDLDAIDAS
LRDSGDGLLA DDRLAALRHA VETFGFHLQG LDMRQNSEVH EQVVAELLAW AGVHPDYASL
PEPERVRILS TELSTRRPLL GPHARLSELA AKELGIVRAA ADVVATFGEP AIPNYIISMC
TSVSDMLEAA LLLKEGGLLD PGAPDGSPSC AAGIVPLFET IEDLGAGAAT LAAVLEVPVY
RELVAAKGMR QEVMLGYSDS NKDGGYLAAN WALYRAELDL VEVARKTGIR LRLFHGRGGT
VGRGGGRSYD AILAQPAGAV HGSLRLTEQG EVIAAKYAES GSAHRNLESL IAGTLESTLL
DMEGLGADAE PSYQLMDELA ARARAAYARL VHETPGFVEY FRQSTPVAEV GDLNIGSRPA
SRKPTNSVAD LRAIPWVMSW SQARVMLPGW YGTGTALEEW VDDDPQRLAT LADLYRRWPF
FRTVLSNLAQ VMAKSDLAIA ARYAELVEDT ALREHIFGMI RDEHARTIRM HAAITGNDHL
LSDNPSLAES IRNRFPYLEP LNQMQVELLR RLRAGDDSEL VKRGILLTMN GLATALRNSG
//