ID   H6R109_NOCCG            Unreviewed;       370 AA.
AC   H6R109;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   03-APR-2013, entry version 8.
DE   RecName: Full=Pseudouridine synthase;
DE            EC=5.4.99.-;
GN   OrderedLocusNames=NOCYR_2203;
OS   Nocardia cyriacigeorgica (strain GUH-2).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=1127134;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GUH-2;
RX   PubMed=22461543; DOI=10.1128/JB.00161-12;
RA   Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA   Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA   Nazaret S., Neto M., Petit S., Roche D., Vallenet D.,
RA   Rodriguez-Nava V., Richard Y., Cournoyer B., Blaha D.;
RT   "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT   cyriacigeorgica GUH-2.";
RL   J. Bacteriol. 194:2098-2099(2012).
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase rsuA family.
CC   -!- SIMILARITY: Contains 1 S4 RNA-binding domain.
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DR   EMBL; FO082843; CCF62981.1; -; Genomic_DNA.
DR   RefSeq; YP_005263617.1; NC_016887.1.
DR   EnsemblBacteria; CCF62981; CCF62981; NOCYR_2203.
DR   GeneID; 11927088; -.
DR   KEGG; ncy:NOCYR_2203; -.
DR   KO; K06178; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR000748; PsdUridine_synth_RsuA/RluB/E/F.
DR   InterPro; IPR018496; PsdUridine_synth_RsuA/RluB_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluD.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR   TIGRFAMs; TIGR00093; TIGR00093; 1.
DR   PROSITE; PS01149; PSI_RSU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; RNA-binding.
SQ   SEQUENCE   370 AA;  40118 MW;  BFE41E12F60B6B52 CRC64;
     MNTPARRDGT PDRRKRNDQH PRSGRPVGTR DARAAQRGVT PRGAAGADPR RGSGGSAGAQ
     RGGSATPAQR GAQGAARRPD RAQPPRKNKP PKPQRQTASA PQLSNAKPAK RQHVEPAEGT
     HTKLPWGEGE RLQKVLAKAG VASRRAAEDM IAQGRVEVDG MIVREQGLRI DPQHAVIRVD
     GTRVVVREEL VHLALNKPKG WQSTMSDDLG RPCVGDIVAE RIAAGQRLFH VGRLDADTEG
     LLLLTNDGDL AHRLMHPSFE VSKTYLATVN GEVHRAVGKQ LRDGVELEDG PAKVDRFQVL
     DIGEGRSLVK IVLHEGRKHI VRRLLDAVGH PVTRLVRTDI GPVALGDQRP GTLRVLGRDE
     IGKLYEAVSL
//