ID H6RB75_NOCCG Unreviewed; 320 AA.
AC H6RB75;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 03-APR-2013, entry version 6.
DE RecName: Full=Proline iminopeptidase;
DE EC=3.4.11.5;
GN Name=pip; OrderedLocusNames=NOCYR_1723;
OS Nocardia cyriacigeorgica (strain GUH-2).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Nocardiaceae; Nocardia.
OX NCBI_TaxID=1127134;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GUH-2;
RX PubMed=22461543; DOI=10.1128/JB.00161-12;
RA Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA Nazaret S., Neto M., Petit S., Roche D., Vallenet D.,
RA Rodriguez-Nava V., Richard Y., Cournoyer B., Blaha D.;
RT "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT cyriacigeorgica GUH-2.";
RL J. Bacteriol. 194:2098-2099(2012).
CC -!- CATALYTIC ACTIVITY: Release of N-terminal proline from a peptide.
CC -!- SIMILARITY: Belongs to the peptidase S33 family.
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DR EMBL; FO082843; CCF62509.1; -; Genomic_DNA.
DR RefSeq; YP_005263149.1; NC_016887.1.
DR EnsemblBacteria; CCF62509; CCF62509; NOCYR_1723.
DR GeneID; 11926611; -.
DR KEGG; ncy:NOCYR_1723; -.
DR KO; K01259; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR002410; Peptidase_S33.
DR InterPro; IPR005944; Pro_iminopeptidase.
DR PANTHER; PTHR10992:SF12; PTHR10992:SF12; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PIRSF; PIRSF006431; Pept_S33; 1.
DR PRINTS; PR00111; ABHYDROLASE.
DR PRINTS; PR00793; PROAMNOPTASE.
DR TIGRFAMs; TIGR01249; pro_imino_pep_1; 1.
PE 3: Inferred from homology;
KW Aminopeptidase; Complete proteome; Hydrolase; Protease.
FT ACT_SITE 114 114 Nucleophile (By similarity).
FT ACT_SITE 270 270 By similarity.
FT ACT_SITE 298 298 Proton donor (By similarity).
SQ SEQUENCE 320 AA; 35457 MW; FC6A2D7EDCB896DD CRC64;
MRTLYPPIEP HQRGMLDVGA GQSVYWEVSG NPEGKPAVFL HGGPGGGTAP FHRQFFDPEQ
YRIVLFDQRG CGRSTPHIAD GADLSVNTTD HLIADIEQLR EALGIEQWLV FGGSWGSTLA
LAYAQRYPQR VTELVLRGIF LLRRKEIDWY YNGAAGYVYP DEWEKFLAPV PEAERDGDLV
EAYHRLLHSP DEEIATAAAV AWSTWEGATS SLLPQPDRVA ETGEPRFALA FARIENHYFR
HGGFLDEGQL LRDIDKIAGI PAVIVQGRHD IVCPAVSAWE LHRAWPGSVL HIVDDAGHAA
NEPGITHHLV EATDGFAKGR
//
