GenomeNet

Database: UniProt/TrEMBL
Entry: H9FX47_MACMU
LinkDB: H9FX47_MACMU
Original site: H9FX47_MACMU 
ID   H9FX47_MACMU            Unreviewed;      2963 AA.
AC   H9FX47;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   25-APR-2018, entry version 46.
DE   SubName: Full=ASH1 like histone lysine methyltransferase {ECO:0000313|Ensembl:ENSMMUP00000042046};
DE   SubName: Full=Putative histone-lysine N-methyltransferase ASH1L {ECO:0000313|EMBL:AFE79206.1};
GN   Name=ASH1L {ECO:0000313|EMBL:AFE79206.1,
GN   ECO:0000313|Ensembl:ENSMMUP00000042046};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|EMBL:AFE79206.1};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000042046, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000042046,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|EMBL:AFE79206.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Caudate {ECO:0000313|EMBL:AFE79206.1}, and Thymus
RC   {ECO:0000313|EMBL:AFH33203.1};
RX   PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA   Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X.,
RA   Pandey S., Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P.,
RA   Tharp G.K., Marcais G., Roberts M., Ferguson B., Fox H.S.,
RA   Treangen T., Salzberg S.L., Yorke J.A., Norgren R.B.Jr.;
RT   "A new rhesus macaque assembly and annotation for next-generation
RT   sequencing analyses.";
RL   Biol. Direct 9:20-20(2014).
RN   [3] {ECO:0000313|Ensembl:ENSMMUP00000042046}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000042046};
RG   Ensembl;
RL   Submitted (OCT-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
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DR   EMBL; JSUE03002512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03002513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03002514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03002515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03002516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03002517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03002518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03002519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03002520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JU335453; AFE79206.1; -; mRNA.
DR   EMBL; JU476399; AFH33203.1; -; mRNA.
DR   RefSeq; XP_014967014.1; XM_015111528.1.
DR   RefSeq; XP_014967024.1; XM_015111538.1.
DR   RefSeq; XP_014967033.1; XM_015111547.1.
DR   RefSeq; XP_014967042.1; XM_015111556.1.
DR   UniGene; Mmu.10178; -.
DR   Ensembl; ENSMMUT00000070742; ENSMMUP00000042046; ENSMMUG00000023146.
DR   GeneID; 717778; -.
DR   KEGG; mcc:717778; -.
DR   CTD; 55870; -.
DR   eggNOG; KOG1083; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   GeneTree; ENSGT00780000121845; -.
DR   KO; K06101; -.
DR   Proteomes; UP000006718; Chromosome 1.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046975; F:histone methyltransferase activity (H3-K36 specific); IEA:Ensembl.
DR   GO; GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046697; P:decidualization; IEA:Ensembl.
DR   GO; GO:0097676; P:histone H3-K36 dimethylation; IEA:Ensembl.
DR   GO; GO:0032635; P:interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0002674; P:negative regulation of acute inflammatory response; IEA:Ensembl.
DR   GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
DR   GO; GO:0043409; P:negative regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0007338; P:single fertilization; IEA:Ensembl.
DR   GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR   GO; GO:0097722; P:sperm motility; IEA:Ensembl.
DR   GO; GO:1903699; P:tarsal gland development; IEA:Ensembl.
DR   GO; GO:1903709; P:uterine gland development; IEA:Ensembl.
DR   GO; GO:0061038; P:uterus morphogenesis; IEA:Ensembl.
DR   Gene3D; 1.20.920.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF01426; BAH; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00384; AT_hook; 4.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00439; BAH; 1.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF47370; SSF47370; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS51038; BAH; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
PE   2: Evidence at transcript level;
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01011399};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675,
KW   ECO:0000313|EMBL:AFE79206.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533,
KW   ECO:0000313|EMBL:AFE79206.1}; Zinc {ECO:0000256|SAAS:SAAS01006535};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS01007077}.
FT   DOMAIN     2085   2136       AWS. {ECO:0000259|PROSITE:PS51215}.
FT   DOMAIN     2139   2255       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN     2263   2279       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   DOMAIN     2457   2527       Bromo. {ECO:0000259|PROSITE:PS50014}.
FT   DOMAIN     2655   2792       BAH. {ECO:0000259|PROSITE:PS51038}.
SQ   SEQUENCE   2963 AA;  332151 MW;  45359BEF20C7CB26 CRC64;
     MDPRNTAMLG LGSDSEGFTR KSPSAISTGT LVSKREVELE KNTKEEEDLR KRNRERNIEA
     GKDDGLTDAQ QQFSVKETNF SEGNLKLKIG LQAKRTKKPP KNLENYVCRP AIKTTIKHPR
     KALKSGKMTD EKNEHCPSKR DPSKLYKKAD DVAAIECQSE EVIHLHSQGE NNPLSKKLSP
     VHSEMADYIN ATPSTLVGSR DPDLKDRALL NGGTSVTEKL AQLIATCPPS KSSKTKPKKL
     GTGTTAGLVS KDLIRKAGVG SVAGIIHKDL IKKPTISTAV GLVTKDPGKK PVFNAAVGLV
     NKDSVKKLGT GTTAVFINKD LGKKPGTITT VGLLSKDSGK KLGIGIVPGL VNKESGKKLG
     LGTVVGLVNK DLGKKLGSTV GLVAKDCAKK IVASSAMGLV NKDIGKKLVS CPLAGLISKD
     AINLKAEALL PTQEPLKASC STNINNQDSQ ELSESLKDSA TSKTFEKNVI RQTKESILEK
     FSVRKETINL EKEMFNEGTS IQQDSFSSNE RGSYETSKHE KQTPVYCTSP DFQMGGASDV
     STAKSPFSAV GESNLPSPSP TVSVNPLTRS PPETSSQLAP NPLLLSSTTE LIEEISESVG
     KNQFTSESTH LNVGHRSVGH SISIECKGID KEVNDSKTTH IDIPRISSSL GKKPSLTSES
     SIHTITPSVV NFTSLFSNKP FLKLGAVSAS DKHCQVAESL STSLQSKPLK KRKGRKPRWT
     KVVARSTCRS PKGLELERSE LFKNVSCSSL SNSNSEPAKF MKNIGPPSFV DHDFLKRRLP
     KLSKSTAPSL ALLADSEKPS HKSFATHKLS SSMCVSSDLL SDIYKPKRGR PKSKEMPQLE
     GPPKRTLKIP ASKVFSLQSK EEQEPPILQP EIEIPSFKQS LSVSPFPKKR GRPKRQMRSP
     VKMKPPVLSV APFVATESPS KLESESDNHR SSSDFFESED QLQDPDDLDD SHRPSVCSMS
     DLEMEPDKKI TKRNNGQLMK TIIRKINKMK TLKRKKLLNQ ILSSSVESSN KGKVQSKLNT
     VSSLAATFGS KLGQQINVSK KGTIYIGKRR GRKPKTVLNG ILSGSPTSLA VLEQTAQQAT
     GSALGQILPP LLPSSASSSE ILPSPICSQS SGTSGGQSPV SSDAGFVEPS SVPYLHLHSR
     QGSMIQTLAM KKASKGRRRL SPPTLLPNSP SHLSELTSLK EATPSPISES HSDETIPSDS
     GIGTDNNSTS DRAEKFCGQK KRRHSFEHVS LIPPETSTVL SSLKEKHKHK CKRRNHDYLS
     YDKMKRQKRK RKKKYPQLRN RQDPDFIAEL EELISRLSEI RITHRSHHFI PRDLLPTIFR
     INFNSFYTHP SFPLDPLHYI RKPDLKKKRG RPPKMREAMA EMPFMHSLSF PLSSTGFYPS
     YGMPYSPSPL TAAPIGLGYY GRYPPTLYPP PPSPSFTTPL PPPSYMHAGH LLLNPAKYHK
     KKHKLLRQEA FLTTSRTPLL SMSTYPSVPP EMAYGWMVEH KHRHRHKHRE HRSSEQPQVS
     MDTGASRSVL ESLKRYRFGK DTVGERYKHK EKHRCHMSCP HLSPSKSLIN REEQWVHREP
     SESSPLALGL QTPLQIDCSE SSPSLSLGGF TPNSEPASSD EHTNLFTSAI GSCRVSNPNS
     SGRKKLTDSP GLFSAQDTSL NRSHRKESLP SNERAVQTSA GSQPTSDKPS QRPSESTNCS
     PTRKRSSSES TSSTVNGVPS RSPRLVASGD DSVDSLLQRM VQNEDQEPME KRIDAVIATA
     SAPPSSSPGR SHSKDRTLGK PDSLLVPAVA SDSCNNSISL LSEKLTSSCS PHHIKRSVVE
     AMQRQARKMC NYNKILATKK NLDHVNKILK AKKLQRQART GNNFVKRRPG RPRKCPLQAV
     VSMQAFQAAQ FVNPELNRGE EGAALHLSPD TVTDVIEAVV QSVNLNPEHK KGLKRKGWLL
     EEQTRKKQKP LPEEEEQENN KSFNEAPVEI PSPPETPAKP PEPESTLQPV LSLIPREKKP
     PRPPKKKYQK AGLYSDVYKT TDPKSRLIQL KKEKLEYTPG EHEYGLFPAP IHVGKYLRQK
     RIDFQLPYDI LWQWKHNQLY KKPDVPLYKK IRSNVYVDVK PLSGYEATTC NCKKPDDDTR
     KGCVDDCLNR MIFAECSPNT CPCGEQCCNQ RIQRHEWVQC LERFRAEEKG WGIRTKEPLK
     AGQFIIEYLG EVVSEQEFRN RMIEQYHNHS DHYCLNLDSG MVIDSYRMGN EARFINHSCD
     PNCEMQKWSV NGVYRIGLYA LKDMPAGTEL TYDYNFHSFN VEKQQLCKCG FEKCRGIIGG
     KSQRVNGLSS SKNSQPMATH KKSGRSKEKR KSKHKLKKRR GHLSEEPNEN INTPTRLTPQ
     LQMKPMSNRE RNFVLKHHVF LVRNWEKIRQ KQEEVKHTSD NIHSASLYTR WNGICRDDGN
     IKSDVFMTQF SALQTARSVR TRRLAAAEEN IEVARAARLA QIFKEICDGI ISYKDSSRQA
     LAAPLLNLPP KKKNADYYEK ISDPLDLITI EKQILIGYYK TVEAFDADML KVFRNAEKYY
     GRKSPIGRDV CRLRKAYYNA RHEASAQIDE IVGETASEAD SSETSVSEKE NGHEKDDDVI
     RCICGLYKDE GLMIQCDKCM VWQHCDCMGV NSDVEHYLCE QCDPRPVDRE VPMIPRPHYA
     QPGCVYFICL LRDDLLLRQG DCVYLMRDSR RTPDGHPVRQ SYRLLSHINR DKLDIFRIEK
     LWKNEKEERF AFGHHYFRPH ETHHSPSRRF YHNELFRVPL YEIIPLEAVV GTCCVLDLYT
     YCKGRPKGVK EQDVYICDYR LDKSAHLFYK IHRNRYPVCT KPYAFDHFPK KLTPKKDFSP
     HYVPDNYKRN GGRSSWKSER SKPPLKDLGQ EDDALPLIEE VLARQEQTAS EIPSLEEPER
     EGATANVSEG EKKTEESSQE PQSTCTPEER RHNQRERLNQ ILLNLLEKIP GKNAIDVTYL
     LEEGSGRKLR RRTLFIPENS FRK
//
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