ID H9G5E8_ANOCA Unreviewed; 369 AA.
AC H9G5E8;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Apolipoprotein A4 {ECO:0000313|Ensembl:ENSACAP00000001607.2};
GN Name=APOA4 {ECO:0000313|Ensembl:ENSACAP00000001607.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000001607.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000001607.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000001607.2};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000001607.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000256|ARBA:ARBA00008788}.
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DR RefSeq; XP_008121792.1; XM_008123585.2.
DR RefSeq; XP_008121793.1; XM_008123586.2.
DR RefSeq; XP_016854161.1; XM_016998672.1.
DR AlphaFoldDB; H9G5E8; -.
DR STRING; 28377.ENSACAP00000001607; -.
DR Ensembl; ENSACAT00000001646.2; ENSACAP00000001607.2; ENSACAG00000001641.2.
DR GeneID; 100556939; -.
DR KEGG; acs:100556939; -.
DR eggNOG; ENOG502QSC5; Eukaryota.
DR GeneTree; ENSGT00950000182929; -.
DR HOGENOM; CLU_058447_0_0_1; -.
DR InParanoid; H9G5E8; -.
DR OMA; VIWKYFT; -.
DR OrthoDB; 4637112at2759; -.
DR TreeFam; TF334458; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000001641; Expressed in kidney and 2 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0042627; C:chylomicron; IBA:GO_Central.
DR GO; GO:0034364; C:high-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:Ensembl.
DR GO; GO:0016209; F:antioxidant activity; IEA:Ensembl.
DR GO; GO:0120020; F:cholesterol transfer activity; IEA:Ensembl.
DR GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central.
DR GO; GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0033344; P:cholesterol efflux; IBA:GO_Central.
DR GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Ensembl.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:Ensembl.
DR GO; GO:0002227; P:innate immune response in mucosa; IEA:Ensembl.
DR GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0016042; P:lipid catabolic process; IEA:Ensembl.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR GO; GO:0034445; P:negative regulation of plasma lipoprotein oxidation; IEA:Ensembl.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IBA:GO_Central.
DR GO; GO:0033700; P:phospholipid efflux; IBA:GO_Central.
DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IBA:GO_Central.
DR GO; GO:0010898; P:positive regulation of triglyceride catabolic process; IBA:GO_Central.
DR GO; GO:0065005; P:protein-lipid complex assembly; IEA:Ensembl.
DR GO; GO:0030300; P:regulation of intestinal cholesterol absorption; IBA:GO_Central.
DR GO; GO:0019430; P:removal of superoxide radicals; IEA:Ensembl.
DR GO; GO:0006982; P:response to lipid hydroperoxide; IEA:Ensembl.
DR GO; GO:0035634; P:response to stilbenoid; IEA:Ensembl.
DR GO; GO:0043691; P:reverse cholesterol transport; IBA:GO_Central.
DR GO; GO:0070328; P:triglyceride homeostasis; IBA:GO_Central.
DR GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IBA:GO_Central.
DR Gene3D; 1.20.5.20; -; 4.
DR Gene3D; 1.20.120.20; Apolipoprotein; 1.
DR InterPro; IPR000074; ApoA_E.
DR PANTHER; PTHR18976; APOLIPOPROTEIN; 1.
DR PANTHER; PTHR18976:SF34; LIPID-BINDING PROTEIN; 1.
DR Pfam; PF01442; Apolipoprotein; 2.
DR SUPFAM; SSF58113; Apolipoprotein A-I; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..369
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003619679"
SQ SEQUENCE 369 AA; 41017 MW; EA6C567B9D977061 CRC64;
MFLKGAAVFL GLLAIIPGAQ AEVSADQVAD VVWSYFSQLG NNAKEAVAGQ IPTSTEISQK
LNSLFQDNLD TVSAYALELQ KQVVPFAEQL HGRMAEDSQK LKEQLREELD QLRARITPRA
EEVRQQMTGA IQNLQAQLGP YAEELRSQVN RNAAELRQGL EPLAEEMRAK LQENVGDLHG
ALSPYADRLQ QRIEAQVGTL KAALDPYANK LKAEADRTLE ELRAGLAPFA QDAQGQLNRQ
LEGLSFQMQK GIEELRAKLS EGTLDLEAKL SPLAHELREK LQRASELRES LAPYLDGLGG
QIEGRIEEFR QAVGPHGESI NRLLVQKVEE MRSSLEPYAD QAGDHLGFLE KNLRDKLASF
FEALKQKEN
//
