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Database: UniProt/TrEMBL
Entry: I0EH19_HELPX
LinkDB: I0EH19_HELPX
Original site: I0EH19_HELPX 
ID   I0EH19_HELPX            Unreviewed;       314 AA.
AC   I0EH19;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=Catalase-related peroxidase {ECO:0000256|PIRNR:PIRNR000296};
DE            EC=1.11.1.- {ECO:0000256|PIRNR:PIRNR000296};
GN   ORFNames=HPPC18_02305 {ECO:0000313|EMBL:AFI02238.1};
OS   Helicobacter pylori PeCan18.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=1163742 {ECO:0000313|EMBL:AFI02238.1, ECO:0000313|Proteomes:UP000005006};
RN   [1] {ECO:0000313|EMBL:AFI02238.1, ECO:0000313|Proteomes:UP000005006}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PeCan18 {ECO:0000313|EMBL:AFI02238.1,
RC   ECO:0000313|Proteomes:UP000005006};
RA   Kersulyte D., Ramirez Ramos A., Recarvarren S., Barua R.L., Watanabe J.,
RA   Gilman R.H., Berg D.E.;
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has an organic peroxide-dependent peroxidase activity.
CC       {ECO:0000256|PIRNR:PIRNR000296}.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000296};
CC   -!- SIMILARITY: Belongs to the catalase family.
CC       {ECO:0000256|PIRNR:PIRNR000296}.
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DR   EMBL; CP003475; AFI02238.1; -; Genomic_DNA.
DR   RefSeq; WP_000719585.1; NC_017742.1.
DR   AlphaFoldDB; I0EH19; -.
DR   KEGG; hca:HPPC18_02305; -.
DR   PATRIC; fig|1163742.3.peg.475; -.
DR   HOGENOM; CLU_045961_2_0_7; -.
DR   Proteomes; UP000005006; Chromosome.
DR   GO; GO:0004096; F:catalase activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd08153; srpA_like; 1.
DR   Gene3D; 1.20.1280.120; -; 1.
DR   Gene3D; 2.40.180.10; Catalase core domain; 1.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR020835; Catalase_sf.
DR   InterPro; IPR024168; Catalase_SrpA-type_pred.
DR   PANTHER; PTHR11465; CATALASE; 1.
DR   PANTHER; PTHR11465:SF9; CATALASE; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   PIRSF; PIRSF000296; SrpA; 1.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF56634; Heme-dependent catalase-like; 1.
PE   3: Inferred from homology;
KW   Heme {ECO:0000256|PIRNR:PIRNR000296, ECO:0000256|PIRSR:PIRSR000296-2};
KW   Iron {ECO:0000256|PIRNR:PIRNR000296, ECO:0000256|PIRSR:PIRSR000296-2};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000296,
KW   ECO:0000256|PIRSR:PIRSR000296-2};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000296};
KW   Peroxidase {ECO:0000256|PIRNR:PIRNR000296};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..314
FT                   /note="Catalase-related peroxidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003625459"
FT   DOMAIN          20..314
FT                   /note="Catalase core"
FT                   /evidence="ECO:0000259|SMART:SM01060"
FT   ACT_SITE        45
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000296-1"
FT   BINDING         306
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000296-2"
SQ   SEQUENCE   314 AA;  35934 MW;  8B285EDA2B280F67 CRC64;
     MKKIGLSLCL VLSLGFLKAH EVSAEEIADI FYKLNAKEPK MKINHTKGFC AKGVFLPNLQ
     ARENLEVPLL NEKEIPASVR YSLGGVAMDD KSKVRGMALK LENQNASWTM VMLNTEINFA
     KNPKEFAQFF EMRLPKNGKV DEARIKKLYE EVPSYRNFAA YMKTIGISSS VANTPYYSVH
     AFKFKDKEEK LLPARWKFVP KDGVKYLNSQ ELKQKDSNYL LSSFQQHLKT KPIEYQMYLV
     FANKNDATND TTALWKGKHK ELLVGTLKVE KYEGMGCNKD VYFPADLPKG VEAPTDPLFQ
     IRNEVYGITF SRRQ
//
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