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Database: UniProt/TrEMBL
Entry: I0Z5U6_COCSC
LinkDB: I0Z5U6_COCSC
Original site: I0Z5U6_COCSC 
ID   I0Z5U6_COCSC            Unreviewed;      1267 AA.
AC   I0Z5U6;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   25-OCT-2017, entry version 27.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=COCSUDRAFT_40196 {ECO:0000313|EMBL:EIE26015.1};
OS   Coccomyxa subellipsoidea (strain C-169) (Green microalga).
OC   Eukaryota; Viridiplantae; Chlorophyta; Trebouxiophyceae;
OC   Trebouxiophyceae incertae sedis; Coccomyxaceae; Coccomyxa.
OX   NCBI_TaxID=574566 {ECO:0000313|EMBL:EIE26015.1, ECO:0000313|Proteomes:UP000007264};
RN   [1] {ECO:0000313|EMBL:EIE26015.1, ECO:0000313|Proteomes:UP000007264}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C-169 {ECO:0000313|EMBL:EIE26015.1,
RC   ECO:0000313|Proteomes:UP000007264};
RX   PubMed=22630137; DOI=10.1186/gb-2012-13-5-r39;
RA   Blanc G., Agarkova I., Grimwood J., Kuo A., Brueggeman A., Dunigan D.,
RA   Gurnon J., Ladunga I., Lindquist E., Lucas S., Pangilinan J.,
RA   Proschold T., Salamov A., Schmutz J., Weeks D., Yamada T.,
RA   Claverie J.M., Grigoriev I., Van Etten J., Lomsadze A., Borodovsky M.;
RT   "The genome of the polar eukaryotic microalga coccomyxa subellipsoidea
RT   reveals traits of cold adaptation.";
RL   Genome Biol. 13:R39-R39(2012).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EIE26015.1}.
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DR   EMBL; AGSI01000003; EIE26015.1; -; Genomic_DNA.
DR   RefSeq; XP_005650559.1; XM_005650502.1.
DR   GeneID; 17044019; -.
DR   KEGG; csl:COCSUDRAFT_40196; -.
DR   KO; K10777; -.
DR   Proteomes; UP000007264; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 3.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007264};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007264}.
FT   DOMAIN      368    519       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      699    790       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   COILED      916    943       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1267 AA;  139531 MW;  F8FC19CBD9E91C33 CRC64;
     MKPKPSELRF KTLCDFFDAC ASRKKSSRKK ELLRDFANKF IERGSSDVYE IYRLMAPSLD
     KERDHYNLRE ANLVRVLIKA CLLDPKTSSA AKRAENWRQA GVKNAGQFSN VMEEYLFRTC
     CGKQRGMSGE AELTVGELND ILNKLAGGGG EEQVKLFTHL IQITTATQMR WIVQIVLRDL
     KIGLSETSIL KEYHVDAVER YNVTCDFPGV IRELTDPHKR FPFQDIKVGK PAKPQLARAV
     KGPEEAFNIM KGRPFVVETK FDGERMQVHV MEDEVQYYSR RGIEHGTYSH YTMLDSFIRK
     QLRETNVILD GEVVVWNKTK KKFEPFGGMK GAVLAAKDNK GPDEKLEMNG WHGDTMTSDP
     DYETPFVKDL ELVFVVFDIL YLRDQSVINR TLLERHELLK ELVIPAPAEG HPVSCAMTGR
     MVCLLPGAPL ITGVPGSKLS YVLDDIQEKF EESIRVNEEG IVVKAADSPW RCNDRGMAWL
     KIKADYVHKV EIDAVIIGAK FGTGRRGGAI AEYLLALAEV PQGGTTEPST FVSFCVVGTG
     VNDADRDTLA KRLEPLFVDN VKGKNCVPRC YRTTGMPKER PDVWIKDPTR SVVLQVQADV
     RTIVSKQFAS RHSLRFPRVQ RVRWDKGPLD IQTDQELWDI VESNQGAIVG GEGHDMESPA
     GKGKGRGKKR AVKGAATPAQ QRSKVVEQFL PTDVSHIRRE CDALRDSLVY FVPAPVKTAK
     YPKKYLEEVV ARLGGKVTQN YVPRVTHVIA QDANDPFFKA RRDKVDMISV EWLLECAAKQ
     ALISLRPHHY MHLTRDTRNN VPNVCIYGDM YYEDVSAIDV KVILNNHAHL EPGALDDLAA
     LMADEAGEPQ PGVASRADGT AQLYKRLKRK PGVEDIMLAV DRELAEYGLL DSTACLFRGC
     HICLLQLPDD TCPAAKDSAQ ESAAAAKREL AALQAQRRKL EVMLHGGKAQ DAIDMSTTHI
     VVIPPANCAM PRLSPADLLG ILHSEKGGTA GLTTLRKLLA AGEVHIVMQS WLEESLEALR
     QAAEGQAVRR ASELRHTVPL SSDSAPDTVA DAPEDIPRNV DSYVLTFAAA SFEDWGWEDF
     GVTTAATPVT SGKRGRSTSP GEGTAGTRAK RGRGSRSGKT AGSTRGRGGK AAKPPPLAPD
     VGKKPSRGGA GRGRGRGRKK YVIDDTSSSS DGEQPDMDAS VSAHGHQSTS MLEDLLSLPI
     TGNDALPAPA IGGPVFSAGS RKHRCWSSER QAGFRSSSSA GRQCSPVDTR KFTAFGRATA
     FGRAAHC
//
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