GenomeNet

Database: UniProt/TrEMBL
Entry: I2H6P9_TETBL
LinkDB: I2H6P9_TETBL
Original site: I2H6P9_TETBL 
ID   I2H6P9_TETBL            Unreviewed;       972 AA.
AC   I2H6P9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   07-JUN-2017, entry version 29.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=TBLA0G01040 {ECO:0000313|EMBL:CCH62051.1};
GN   ORFNames=TBLA_0G01040 {ECO:0000313|EMBL:CCH62051.1};
OS   Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 /
OS   NBRC 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
OC   Tetrapisispora.
OX   NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH62051.1, ECO:0000313|Proteomes:UP000002866};
RN   [1] {ECO:0000313|EMBL:CCH62051.1, ECO:0000313|Proteomes:UP000002866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC   UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S.,
RA   Byrne K.P., Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type
RT   switching accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; HE806322; CCH62051.1; -; Genomic_DNA.
DR   RefSeq; XP_004181570.1; XM_004181522.1.
DR   EnsemblFungi; CCH62051; CCH62051; TBLA_0G01040.
DR   GeneID; 14497183; -.
DR   KEGG; tbl:TBLA_0G01040; -.
DR   InParanoid; I2H6P9; -.
DR   KO; K10777; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000002866; Chromosome 7.
DR   GO; GO:0032807; C:DNA ligase IV complex; IEA:EnsemblFungi.
DR   GO; GO:0000790; C:nuclear chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:EnsemblFungi.
DR   GO; GO:0001302; P:replicative cell aging; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF84; PTHR10459:SF84; 1.
DR   Pfam; PF16589; BRCT_2; 2.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF50249; SSF50249; 2.
DR   SUPFAM; SSF52113; SSF52113; 3.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002866};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002866}.
FT   DOMAIN      391    523       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      706    805       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      870    971       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   972 AA;  111977 MW;  8E9984F9905F8756 CRC64;
     MNSSNEVIIP VSTTTKESPA TTPKNFAPSP DFKWLCDELF VKIDKIREQI KNKTANTISN
     KPISTRYFDT ITHFIKLWRT TIGDDIFPAL RLILPYRDRR VYNIKDLTLI RAICSYLKLP
     KNSVVERRLI RWKYKADRYE TLATFCIHEI SKRKNEPQVT QVERISIDKL NEILDDLVVN
     RQNWNNKKRS NLLQVETFKF CLENMTFIEL KYFFDIIVKN KILGSLENMF LKIWHPDSKE
     YLSVVSDLRT LSNKLWNPSI KINNSDLSIK VGYIFAPQLA KRLMLSYDTI SNRLNNDFFI
     EEKMDGERIQ LHYMNYGETV KFFSRHGTDY TYLYGNDKSA GTIAKFLRLH KNVKECVLDG
     EMVTFDSTSK KVLPFGLVKS SASSQLNKKD IDNDSFHPLF MVFDILYLNG SSLIDLPLFK
     RKEFLNTVLT PYKDYVEILS SIRCTDSIQI KKGLDAAISV GSEGIVLKQY ISKYIPNARH
     NNWIKVKPEY LEEFGENMDL IVIGRDSGKK DCLICGILVT EEKQELSENM KRESEIEIIS
     DSGDDDLDTK PSQGIKKVIS FCTIANGLSQ NELKEINRIT RGAWKNYNNE TPPIDVLEFG
     TKKPVEWIYP QDSVVLEIKA RSLDRTDQTQ YKYATGCTLY GGYCRQIRQD KDWTSCYTLH
     DLTYNEIKRH EKKNKNKQTL IRSYSRKKSK IISPAGMLPN GTDLRLISDL FHGLYFYIIS
     DYIPDSDAQR IDREDICSLI IKNGGRVIYN VIAKTYTISK LRILSSKSTI ECTDLVRRGY
     DVINLSWLFD CLQAGVILPL EPAHCLFVSN ELLAIATDRI DKFGDSYEAT LIDSKLLKLL
     DSNINKVNRS NSNLLLINKD EGVDSIPIFL FTNRKFFLIK EDILLGDRDT LIFQIKLYGG
     SLVTKLEDCN IIVGVCGSQL VNKKLGDLRC KLVKQYVDAN FPQPIPRAVN VSWITESIKA
     GYQLSPEDYP IL
//
DBGET integrated database retrieval system