ID I3ISB5_DANRE Unreviewed; 561 AA.
AC I3ISB5; A0A8M3B4Z0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=GPI transamidase component PIG-S isoform X1 {ECO:0000313|RefSeq:XP_009293904.1};
DE SubName: Full=Phosphatidylinositol glycan anchor biosynthesis, class S {ECO:0000313|Ensembl:ENSDARP00000125787};
GN Name=pigs {ECO:0000313|Ensembl:ENSDARP00000125787,
GN ECO:0000313|RefSeq:XP_009293904.1,
GN ECO:0000313|ZFIN:ZDB-GENE-060929-436};
GN Synonyms=zgc:152927 {ECO:0000313|RefSeq:XP_009293904.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000125787};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000125787}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000125787};
RG Ensembl;
RL Submitted (MAY-2012) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000125787, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000125787};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_009293904.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009293904.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGS family.
CC {ECO:0000256|ARBA:ARBA00005316}.
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DR EMBL; CU928208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009293904.1; XM_009295629.3.
DR Ensembl; ENSDART00000151638; ENSDARP00000125787; ENSDARG00000017813.
DR Ensembl; ENSDART00000151638.2; ENSDARP00000125787.1; ENSDARG00000017813.11.
DR GeneID; 767675; -.
DR AGR; ZFIN:ZDB-GENE-060929-436; -.
DR CTD; 94005; -.
DR ZFIN; ZDB-GENE-060929-436; pigs.
DR HOGENOM; CLU_010026_3_0_1; -.
DR OrthoDB; 5476244at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000000437; Chromosome 21.
DR Bgee; ENSDARG00000017813; Expressed in blastula and 27 other cell types or tissues.
DR GO; GO:0042765; C:GPI-anchor transamidase complex; IBA:GO_Central.
DR GO; GO:0016255; P:attachment of GPI anchor to protein; IBA:GO_Central.
DR InterPro; IPR019540; PtdIno-glycan_biosynth_class_S.
DR PANTHER; PTHR21072; GPI TRANSAMIDASE COMPONENT PIG-S; 1.
DR PANTHER; PTHR21072:SF13; GPI TRANSAMIDASE COMPONENT PIG-S; 1.
DR Pfam; PF10510; PIG-S; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3ISB5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 561 AA; 62332 MW; 8E22F8A8BAA9368D CRC64;
MAALQLEKER GRYAALAIAA VVIIVGIPLW WKTTETYRAW LPFSDINELD SLQLRLSVDI
EVVFSRGTLT PEQQKKIPLS HVNEKEHQVD AKTSLRYQYE TRYRTATVME EDALNQPTAA
EADLSLHTLT ESSCGSVVVY VIPESSVLLP EDVKVYVGQR RTALLRSPPI KSSWSLNEVI
SNLNPRVEQI ASTMSFSHQD ITAALSDRVR MTKVTKESMA DSMRAIKSSP GYEITFSLLN
PDPKSHSLHW DIEGALHSYI QPLLNKLAPI ANFSVDSQIL YYAVLGVNPR FDNSVSAYTL
NADSLSHVIN PVEARLGSNA ASSNPVLNFL LYVPDAHHSP LFIRDHSRRE VPTNAFHSPR
WGGIMVYNVN DLYGPESERP VDISINMAKV MGVFLAQLRL MLGVHQTHPP SGFVLQSPGS
AGLADWELDR LMWSRSVENI ATASTTITSL AQLLDQIGNI VINDNIALQV SSAVTSLQAA
VAELDAGNLV FALQYSREAI LASERAFFDP SLLHLLYFPD DQKFAIYIPL FLPMCVPIVL
SLLKIVSEVK KRRAEKQAKS D
//
