ID I3RA20_HALMT Unreviewed; 540 AA.
AC I3RA20;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Alkaline phosphatase {ECO:0000313|EMBL:AFK21080.1, ECO:0000313|EMBL:AHZ24064.1};
DE EC=3.1.4.1 {ECO:0000313|EMBL:AFK21080.1};
GN Name=phoD {ECO:0000313|EMBL:AFK21080.1};
GN OrderedLocusNames=HFX_5248 {ECO:0000313|EMBL:AFK21080.1};
GN ORFNames=BM92_17805 {ECO:0000313|EMBL:AHZ24064.1}, C439_00020
GN {ECO:0000313|EMBL:EMA05137.1}, E6P09_18105
GN {ECO:0000313|EMBL:QCQ77230.1};
OS Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC
OS 14739 / NCIMB 2177 / R-4) (Halobacterium mediterranei).
OG Plasmid HMPLAS2 {ECO:0000313|EMBL:AHZ24064.1,
OG ECO:0000313|Proteomes:UP000027075},
OG Plasmid pHM300 {ECO:0000313|EMBL:AFK21080.1,
OG ECO:0000313|Proteomes:UP000006469}, and
OG Plasmid pHME322 {ECO:0000313|EMBL:QCQ77230.1,
OG ECO:0000313|Proteomes:UP000299011}.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=523841 {ECO:0000313|EMBL:AFK21080.1, ECO:0000313|Proteomes:UP000006469};
RN [1] {ECO:0000313|EMBL:AFK21080.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.2087 {ECO:0000313|EMBL:AFK21080.1};
RX PubMed=22247127; DOI=10.1128/AEM.07114-11;
RA Cai S., Cai L., Liu H., Liu X., Han J., Zhou J., Xiang H.;
RT "Identification of the haloarchaeal phasin (PhaP) that functions in
RT polyhydroxyalkanoate accumulation and granule formation in Haloferax
RT mediterranei.";
RL Appl. Environ. Microbiol. 78:1946-1952(2012).
RN [2] {ECO:0000313|EMBL:AFK21080.1, ECO:0000313|Proteomes:UP000006469}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 /
RC R-4 {ECO:0000313|Proteomes:UP000006469}, and CGMCC 1.2087
RC {ECO:0000313|EMBL:AFK21080.1};
RC PLASMID=pHM300 {ECO:0000313|Proteomes:UP000006469};
RX PubMed=22843593; DOI=10.1128/JB.00880-12;
RA Han J., Zhang F., Hou J., Liu X., Li M., Liu H., Cai L., Zhang B., Chen Y.,
RA Zhou J., Hu S., Xiang H.;
RT "Complete genome sequence of the metabolically versatile halophilic
RT archaeon Haloferax mediterranei, a poly(3-hydroxybutyrate-co-3-
RT hydroxyvalerate) producer.";
RL J. Bacteriol. 194:4463-4464(2012).
RN [3] {ECO:0000313|Proteomes:UP000011603}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 /
RC R-4 {ECO:0000313|Proteomes:UP000011603};
RA Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A.,
RA Eisen J.A., Facciotti M.T.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:EMA05137.1, ECO:0000313|Proteomes:UP000011603}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 {ECO:0000313|EMBL:EMA05137.1}, and ATCC 33500 / DSM
RC 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4
RC {ECO:0000313|Proteomes:UP000011603};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
RN [5] {ECO:0000313|EMBL:AHZ24064.1, ECO:0000313|Proteomes:UP000027075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 {ECO:0000313|EMBL:AHZ24064.1}, and ATCC 33500 / DSM
RC 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4
RC {ECO:0000313|Proteomes:UP000027075};
RC PLASMID=HMPLAS2 {ECO:0000313|EMBL:AHZ24064.1}, and Plasmid HMPLAS2
RC {ECO:0000313|Proteomes:UP000027075};
RA Bautista V.;
RT "Transcriptional profiles of Haloferax mediterranei on the basis of
RT nitrogen availability.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AFK21080.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.2087 {ECO:0000313|EMBL:AFK21080.1};
RC PLASMID=pHM300 {ECO:0000313|EMBL:AFK21080.1};
RA Wang L., Yang H., Xiang H.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:QCQ77230.1, ECO:0000313|Proteomes:UP000299011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 {ECO:0000313|EMBL:QCQ77230.1}, and ATCC 33500 / DSM
RC 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4
RC {ECO:0000313|Proteomes:UP000299011};
RC PLASMID=pHME322 {ECO:0000313|EMBL:QCQ77230.1,
RC ECO:0000313|Proteomes:UP000299011};
RA DasSarma S., DasSarma P., DasSarma S., Fomenkov A., Vincze T., Anton B.P.,
RA Roberts R.J.;
RT "Methylomes of two halophilic Archaea, Haloarcula marismortui and Haloferax
RT mediterranei.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP001870; AFK21080.1; -; Genomic_DNA.
DR EMBL; CP007553; AHZ24064.1; -; Genomic_DNA.
DR EMBL; AOLO01000001; EMA05137.1; -; Genomic_DNA.
DR EMBL; CP039141; QCQ77230.1; -; Genomic_DNA.
DR RefSeq; WP_004056114.1; NZ_CP039141.1.
DR AlphaFoldDB; I3RA20; -.
DR GeneID; 40158372; -.
DR KEGG; hme:HFX_5248; -.
DR PATRIC; fig|523841.21.peg.4; -.
DR HOGENOM; CLU_015982_2_1_2; -.
DR OrthoDB; 304816at2157; -.
DR Proteomes; UP000006469; Plasmid pHM300.
DR Proteomes; UP000011603; Unassembled WGS sequence.
DR Proteomes; UP000027075; Plasmid HMPLAS2.
DR Proteomes; UP000299011; Plasmid pHME322.
DR GO; GO:0004528; F:phosphodiesterase I activity; IEA:UniProtKB-EC.
DR CDD; cd07389; MPP_PhoD; 1.
DR Gene3D; 3.60.21.70; PhoD-like phosphatase; 1.
DR Gene3D; 2.60.40.380; Purple acid phosphatase-like, N-terminal; 1.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR018946; PhoD-like_MPP.
DR InterPro; IPR038607; PhoD-like_sf.
DR InterPro; IPR032093; PhoD_N.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR43606; PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED; 1.
DR PANTHER; PTHR43606:SF2; PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED; 1.
DR Pfam; PF09423; PhoD; 1.
DR Pfam; PF16655; PhoD_N; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR PROSITE; PS51318; TAT; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000313|EMBL:AFK21080.1};
KW Nuclease {ECO:0000256|ARBA:ARBA00022839};
KW Plasmid {ECO:0000313|EMBL:AFK21080.1}.
FT DOMAIN 54..150
FT /note="Phospholipase D N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16655"
FT DOMAIN 163..509
FT /note="PhoD-like phosphatase metallophosphatase"
FT /evidence="ECO:0000259|Pfam:PF09423"
SQ SEQUENCE 540 AA; 60067 MW; 03F2B673642481FF CRC64;
MDVENPPSPD PNAHSRRRFL QRTGGATALA VLGASGQAAA VDEHGRFKAD PFSLGVASGD
PLPDSVILWT RLAPSPLTRG GGMPDKRVPV QWTVAESEDM TPVVQTGNVF ADPAHAHSVH
VNVQNLDPNT EYYYQFRTGG YRSPVGRTKT APEVGATPEE FRFGFASCQA WYDGFYTPYK
HMAADELDLI VHLGDYIYEY GIGPNGGVRD TAVPQAYRSE PTTLDRYRLQ YGLYKSDADL
QAAHASAPWL VTRDDHEVDN NWAGDVPQDP DKQTVEELLK RRAAAFKAYY EHMPFRLEQK
PDGPDQKLYR NYTFGDLVEF NVLDTRLYRS DQACGDAFTV DACQKRFKEN RTILGDRQQA
WLVNNLEASN ATWDVLANQV PFAKMDFLRG AADGYRMDQW DGYVADQVAV KNAFEASVNN
PVVVTGDFHS NWANDIKSAQ NESKTIGTEF IGTSISSGGD GSEFSDINGN KEGVFGKHVV
KENENVKYNN NRRGYTRCTL TPDEWVTEFQ VVDYVTEPGA PVRTDKRFVV EAGTPGLQEP
//
