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Database: UniProt/TrEMBL
Entry: I3U4I1_ENTFC
LinkDB: I3U4I1_ENTFC
Original site: I3U4I1_ENTFC 
ID   I3U4I1_ENTFC            Unreviewed;       212 AA.
AC   I3U4I1;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   27-SEP-2017, entry version 30.
DE   RecName: Full=Thymidine kinase {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU000544};
DE            EC=2.7.1.21 {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU000544};
GN   Name=tdk2 {ECO:0000313|EMBL:AFK59919.1};
GN   Synonyms=tdk {ECO:0000256|HAMAP-Rule:MF_00124};
GN   ORFNames=HMPREF0351_12295 {ECO:0000313|EMBL:AFK59919.1};
OS   Enterococcus faecium DO.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=333849 {ECO:0000313|EMBL:AFK59919.1, ECO:0000313|Proteomes:UP000005269};
RN   [1] {ECO:0000313|EMBL:AFK59919.1, ECO:0000313|Proteomes:UP000005269}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DO {ECO:0000313|EMBL:AFK59919.1,
RC   ECO:0000313|Proteomes:UP000005269};
RX   PubMed=22769602; DOI=10.1186/1471-2180-12-135;
RA   Qin X., Galloway-Pena J.R., Sillanpaa J., Hyeob Roh J.,
RA   Nallapareddy S.R., Chowdhury S., Bourgogne A., Choudhury T.,
RA   Munzy D.M., Buhay C.J., Ding Y., Dugan-Rocha S., Liu W., Kovar C.,
RA   Sodergren E., Highlander S., Petrosino J.F., Worley K.C., Gibbs R.A.,
RA   Weinstock G.M., Murray B.E.;
RT   "Complete genome sequence of Enterococcus faecium strain TX16 and
RT   comparative genomic analysis of Enterococcus faecium genomes.";
RL   BMC Microbiol. 12:135-135(2012).
CC   -!- CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'-
CC       phosphate. {ECO:0000256|HAMAP-Rule:MF_00124,
CC       ECO:0000256|RuleBase:RU000544}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU004165}.
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DR   EMBL; CP003583; AFK59919.1; -; Genomic_DNA.
DR   RefSeq; WP_002320895.1; NC_017960.1.
DR   RefSeq; YP_006376901.1; NC_017960.1.
DR   EnsemblBacteria; AFK59919; AFK59919; HMPREF0351_12295.
DR   GeneID; 13001004; -.
DR   KEGG; efu:HMPREF0351_12295; -.
DR   KO; K00857; -.
DR   Proteomes; UP000005269; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005269};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00124};
KW   DNA synthesis {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544, ECO:0000313|EMBL:AFK59919.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005269};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544, ECO:0000313|EMBL:AFK59919.1};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   NP_BIND      27     34       ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   NP_BIND     103    106       ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   ACT_SITE    104    104       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_00124, ECO:0000256|PIRSR:PIRSR035805-
FT                                1}.
FT   METAL       161    161       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       164    164       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       198    198       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       201    201       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
SQ   SEQUENCE   212 AA;  24482 MW;  C053B04B042684B7 CRC64;
     MLKIKYNTIG TNWKVKKSMA QLFFKYGAMN SGKTIEILKV AHNYEEQNKP VVLMTSGIDT
     RDGLGVVSSR IGLKRNAMPI FEETDVFDVI QKMESKPYCV LIDEAQFLKK KHVIAFTRIV
     DELDIPVMAF GLKNDFRNEL FEGSKYLLLY ADKIEEMKTI CWFCHKKAIM NLHYIDGNPV
     YEGDQVQIGG NEAYYPVCRK HYFHPSMITE GE
//
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