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Database: UniProt/TrEMBL
Entry: I3WKG8_BIFBI
LinkDB: I3WKG8_BIFBI
Original site: I3WKG8_BIFBI 
ID   I3WKG8_BIFBI            Unreviewed;      1690 AA.
AC   I3WKG8;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   07-JUN-2017, entry version 34.
DE   SubName: Full=Sialidase {ECO:0000313|EMBL:AFL05381.1};
DE            EC=3.2.1.18 {ECO:0000313|EMBL:AFL05381.1};
GN   Name=nedA {ECO:0000313|EMBL:AFL05381.1};
GN   ORFNames=BBB_1791 {ECO:0000313|EMBL:AFL05381.1};
OS   Bifidobacterium bifidum BGN4.
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=484020 {ECO:0000313|EMBL:AFL05381.1, ECO:0000313|Proteomes:UP000006173};
RN   [1] {ECO:0000313|EMBL:AFL05381.1, ECO:0000313|Proteomes:UP000006173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGN4 {ECO:0000313|EMBL:AFL05381.1};
RX   PubMed=22887663; DOI=10.1128/JB.00988-12;
RA   Yu D.S., Jeong H., Lee D.H., Kwon S.K., Song J.Y., Kim B.K.,
RA   Park M.S., Ji G.E., Oh T.K., Kim J.F.;
RT   "Complete Genome Sequence of the Probiotic Bacterium Bifidobacterium
RT   bifidum Strain BGN4.";
RL   J. Bacteriol. 194:4757-4758(2012).
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DR   EMBL; CP001361; AFL05381.1; -; Genomic_DNA.
DR   ProteinModelPortal; I3WKG8; -.
DR   EnsemblBacteria; AFL05381; AFL05381; BBB_1791.
DR   KEGG; bbf:BBB_1791; -.
DR   PATRIC; fig|484020.3.peg.1777; -.
DR   KO; K01186; -.
DR   Proteomes; UP000006173; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR018905; A-galactase_NEW3.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013830; SGNH_hydro.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR011040; Sialidases.
DR   PANTHER; PTHR10628; PTHR10628; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF13472; Lipase_GDSL_2; 1.
DR   Pfam; PF10633; NPCBM_assoc; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF50939; SSF50939; 1.
DR   SUPFAM; SSF52266; SSF52266; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006173};
KW   Glycosidase {ECO:0000313|EMBL:AFL05381.1};
KW   Hydrolase {ECO:0000313|EMBL:AFL05381.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006173};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1664   1684       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      256    539       Sialidases. {ECO:0000259|Pfam:PF13088}.
FT   DOMAIN      584    644       NPCBM_assoc. {ECO:0000259|Pfam:PF10633}.
FT   DOMAIN      851   1029       SGNH_hydro. {ECO:0000259|Pfam:PF13472}.
SQ   SEQUENCE   1690 AA;  178187 MW;  7FBE14E1195182DB CRC64;
     MCRWGNLAAG ASAACTWSAS KEFAYHVVTE DDVANGFTPT ATVAATTQDG TNGVLQSVDI
     TGETVPAVPA TSALRVAMQR TDTLGDNVKI GDRLTFNFTY TNKTAQKIYA YPSESNIERV
     DVVSYPSNSC RSGVEANQTA SCGFAYHVIT AEDVVARRYT PTATFRATSD RDGTQVLQDD
     MTFTTGTVTV AGPADDAAST PTERNDGEPL LLATNKQIGD TDYYRIPAIA QAPNGWILAA
     WDLRPKSAAD APNPNSIVQR ISKDGGKSWE TLAYVAQGRS ATNKYGYSDP SYVVDEEAGK
     IFLFCVKSYD QGYFGSVLGV EDARNVLQAV VMESDDNGST WSEPRNITKD ITKGHEDEWK
     SRFASSGHGI QLKYGQYKGR LIQQYAVRTT SNTNIAVSVY SDDHGKTWKA GNPVTEANMD
     ENKVVELSDG RVMLNSRPGA AGYRRVAISE DGGVNYGPIK SETQLPDPNN NAQITRAFPN
     APEGSAKAKV LLYSAPRASN EGRANGVVRV SFDDGTTWSA GKLFKEGSMA YSVITALNDA
     AGGGYGLLYE GESITYTRAS MEWLGYLTAT ASGTATVKEG EGTLTAPVTV TNDGLTDYTN
     VTVTPTGLPS DWSAEAVNVG NLAAGQSATV NVPVTVPAAA VSGTVAKATM KITGKYAQSE
     DTLHSFAEGE LSVTVTDPDP AAKRLKLTIE RTDDNGDPVK VGDTLTYRIT YENVGTQSFA
     VYPRESNLDG VTTPQSASNP APVCRWSRLD PGATGACVSG NGKRLAYHTV TEADATAGSF
     TPSATIDATA DASGETVLES VSITGDPVTV SQPVELPVDI AAWKTRNEAL DDWQTLSEKL
     AKTDRINWLF TGDSITHGVQ FTRGYRTYSE LFANHLDTTP VRGVSRANDV VMNTGISSAD
     ASWPLKDGAF EKWVSDKHPD VVFLTFGMND GRTGQAFTVD QYTANLSTLI DKIRDLGAIP
     VLQTQNYTTN ATFNANLDTY FDAERRLALD KNVLLVDFNK QWLELGGGNR ESGTYMGAGN
     DIHPGENGHI EWAKFTLGAL NMIANDDPLA RWSSSDTTLD KPTVTVDADG NGLKGSDGLE
     PAPAAAKSVG KFLSGAQYVD LGGDVVSAVA GKRESNVTIR FRASATGQPQ TLFSLGDSDS
     ATRATVRLSA TGLVQFLNSG NTGDFYTVGT NDLADGAWHT VSVNFVANGF TIYVDGAAMR
     AISGGAGTQL NVPGAITVNT ATAGAIRGAD SAGGAQQLTG IVDYVAAWSR TLTDAEAKRI
     SAETSAVAVT KVDAAVNALQ PVISDTGARK NIVFVGGETI EGGYTDHLIA KNIVQLLDER
     VRWEYVTGLS ATDRELQRAK FFVAAGQGGL TAKQMDEDYA AMVGEYSPDI LFLAPDLYDA
     DGILAESDAA AFAGHIRSVA AKAKEAGAKV VLVTPVTVRG GEDEYAGAMR TVAKEDDLPL
     IDAQAWIGKV VAADASVKTA WFNKAGQLNY AGHLGYARFM MRSLDLYPSN VSGSRIASLP
     YDTANVTLVG ASENGGELPV GRVEGTDRAH IDTMQIGAAA SLVVTDSYAV YEIGEDGGRT
     LVADGLKPAD VLADGIDVTV NDTAAHRYEV VGSANVPEGA DAVTVTYTAT LAAVEEPEPG
     PDPDPTPDPS EKPDGDGTGD GTGAGAGDVQ KPTPDAVAKT GADVFGLLAA VAVLLAAGGV
     TLSLRRRANR
//
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