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Database: UniProt/TrEMBL
Entry: I3WKG9_BIFBI
LinkDB: I3WKG9_BIFBI
Original site: I3WKG9_BIFBI 
ID   I3WKG9_BIFBI            Unreviewed;       865 AA.
AC   I3WKG9;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   25-OCT-2017, entry version 35.
DE   SubName: Full=Sialidase {ECO:0000313|EMBL:AFL05382.1};
DE            EC=3.2.1.18 {ECO:0000313|EMBL:AFL05382.1};
GN   Name=nedA {ECO:0000313|EMBL:AFL05382.1};
GN   ORFNames=BBB_1792 {ECO:0000313|EMBL:AFL05382.1};
OS   Bifidobacterium bifidum BGN4.
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=484020 {ECO:0000313|EMBL:AFL05382.1, ECO:0000313|Proteomes:UP000006173};
RN   [1] {ECO:0000313|EMBL:AFL05382.1, ECO:0000313|Proteomes:UP000006173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGN4 {ECO:0000313|EMBL:AFL05382.1};
RX   PubMed=22887663; DOI=10.1128/JB.00988-12;
RA   Yu D.S., Jeong H., Lee D.H., Kwon S.K., Song J.Y., Kim B.K.,
RA   Park M.S., Ji G.E., Oh T.K., Kim J.F.;
RT   "Complete Genome Sequence of the Probiotic Bacterium Bifidobacterium
RT   bifidum Strain BGN4.";
RL   J. Bacteriol. 194:4757-4758(2012).
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DR   EMBL; CP001361; AFL05382.1; -; Genomic_DNA.
DR   ProteinModelPortal; I3WKG9; -.
DR   EnsemblBacteria; AFL05382; AFL05382; BBB_1792.
DR   KEGG; bbf:BBB_1792; -.
DR   PATRIC; fig|484020.3.peg.1778; -.
DR   KO; K01186; -.
DR   Proteomes; UP000006173; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR018905; A-galactase_NEW3.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; PTHR10628; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF10633; NPCBM_assoc; 1.
DR   SUPFAM; SSF50939; SSF50939; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006173};
KW   Glycosidase {ECO:0000313|EMBL:AFL05382.1};
KW   Hydrolase {ECO:0000313|EMBL:AFL05382.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006173};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     64       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        65    865       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003681518.
FT   TRANSMEM    840    859       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      264    546       Sialidase. {ECO:0000259|Pfam:PF13088}.
FT   DOMAIN      602    664       NPCBM_assoc. {ECO:0000259|Pfam:PF10633}.
SQ   SEQUENCE   865 AA;  90150 MW;  D828F55761DA21A7 CRC64;
     MVRKPCRPIG GTAVGAQSRD PALHRRGTHM VRSTKPSLLR RLGALVAAAA MLVVLPAGVS
     TASAASDDTD MLTVTMTRTD ALGDEVYVGD TLTYSFTNTN NTSSAFTAFP AESNLSGVLT
     TGTPNCRYEN LAGGASYPCS TASHTITADD LTAGSFTPRT VWKATSDRGG TQVLQDNIVS
     TGDTVTVKEG KRPDPATIPT DRADGEAVRL ATARQNLGTE CYRIPALAEA PNGWILAAFD
     QRPNTAMANG SGVKCWDAPQ PNSIVQRISK DGGKSWTPIQ YVAQGKNAPD RYGYSDPSYV
     VDEETGEIFL FFVHSYNKGF ADSQLGVDES NRNVLHAVVV SSKDNGETWS KPRDITADIT
     KGYENEWKSR FATSGAGIQL KYGKYKGRLI QQYAVGRTTG SNAAVSVYSD DHGKTWQAGN
     PVTGMLMDEN KVVELSDGRV MLNSRPGNGS GYRRVAISKD GGMNYGTVKN ETQLPDPNNN
     AHITRAFPNA PEGSAKAKVL LYSSPRANNE GRANGVVRIS LDDGTTWSSG KLYKEGSMAY
     SVITALSGAA GGGYGLLYEG AWVTGGGIDS HDIMYTHISM DWLGYLSATA DDVTASVEEG
     ASTVDVTVPV SNVGSVDYTG VTVTPADLPT GWSASPVNVG ALAGGASKDV TVTVNVPATA
     TKDDVAKIVL RVTGTSAANA NATTGFDGSI TVNVTEKSEP DPEPEPTITG VSAVTSQAGV
     KVGDVFDASK VSVTAAMSDG SSKALAAGEY SLSAVDADGK AVDLAEPFAA AGVVTVTVSV
     PVEGANPLTA SFTIDVAEKS VDPEPKPEPE PKPEPEKPAG PKVDVPTEQP GLSKTGASTA
     GMSIVFVLLA LSGVAALSLR RRSVH
//
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