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Database: UniProt/TrEMBL
Entry: J3K9B5_COCIM
LinkDB: J3K9B5_COCIM
Original site: J3K9B5_COCIM 
ID   J3K9B5_COCIM            Unreviewed;       446 AA.
AC   J3K9B5;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 2.
DT   05-JUL-2017, entry version 30.
DE   SubName: Full=Histone-lysine N-methyltransferase Clr4 {ECO:0000313|EMBL:EAS31476.3};
GN   ORFNames=CIMG_06955 {ECO:0000313|EMBL:EAS31476.3};
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Coccidioides.
OX   NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS31476.3, ECO:0000313|Proteomes:UP000001261};
RN   [1] {ECO:0000313|Proteomes:UP000001261}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA   Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA   Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA   Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA   Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens
RT   Coccidioides and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2] {ECO:0000313|Proteomes:UP000001261}
RP   GENOME REANNOTATION.
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|SAAS:SAAS00563877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00574581}.
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DR   EMBL; GG704912; EAS31476.3; -; Genomic_DNA.
DR   RefSeq; XP_001243059.2; XM_001243058.2.
DR   STRING; 246410.XP_001243059.1; -.
DR   EnsemblFungi; EAS31476; EAS31476; CIMG_06955.
DR   GeneID; 4561949; -.
DR   KEGG; cim:CIMG_06955; -.
DR   EuPathDB; FungiDB:CIMG_06955; -.
DR   eggNOG; KOG1286; Eukaryota.
DR   eggNOG; COG0531; LUCA.
DR   InParanoid; J3K9B5; -.
DR   KO; K11419; -.
DR   OrthoDB; EOG092C164R; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Chromosome {ECO:0000256|SAAS:SAAS00508265};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001261};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675,
KW   ECO:0000313|EMBL:EAS31476.3};
KW   Nucleus {ECO:0000256|SAAS:SAAS00574642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533,
KW   ECO:0000313|EMBL:EAS31476.3}.
FT   DOMAIN      206    278       Pre-SET. {ECO:0000259|PROSITE:PS50867}.
FT   DOMAIN      281    405       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN      420    436       Post-SET. {ECO:0000259|PROSITE:PS50868}.
SQ   SEQUENCE   446 AA;  50696 MW;  CAAE35FD83CEDC76 CRC64;
     MVIDLTADTT SEEEQTSYPF KAIGTSLRTS QLLLTGFTQL GERNITNGKR ELFARKQTRE
     SLLELDILAA RFSSSETETF YSTQKRRRDE EDSPASSLPP HHGLSQHYLV NDVQRCMSVM
     YMKAKKGKRS ATKLPRATRT FRAGKPANHT ALDLQNLYIE KLLSIDGPPV YFACNHATRD
     VDFNFEFVSC YKMHKGVTPV DASFHAGCSC FTEKCDLNIC TCPSQEEGSD QRIVPYKVGD
     NGAVVLREDF MERKSMIYEC SMLCSCSSTC MNRVVERGRK VRLEIFETRN RGFGLRSKNS
     IQAGQYIDCY LGELLTKSEA DNREKAISNK ASYLFSLDFL VDDEEVYVVD GRKFGSVTRF
     MNHSCNPNCK MFPVSHKHAD QRIFGLAFFA LTNIPAGTEL TFDYHPNWNP IKDGKDIDPD
     AVKCLCEERN CRGQLWPSQR KTLQED
//
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