ID J3KDB5_COCIM Unreviewed; 1176 AA.
AC J3KDB5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=SH3 domain-containing protein {ECO:0000313|EMBL:EAS33337.3};
GN ORFNames=CIMG_04361 {ECO:0000313|EMBL:EAS33337.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS33337.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704914; EAS33337.3; -; Genomic_DNA.
DR RefSeq; XP_001244920.1; XM_001244919.2.
DR AlphaFoldDB; J3KDB5; -.
DR STRING; 246410.J3KDB5; -.
DR GeneID; 4563869; -.
DR KEGG; cim:CIMG_04361; -.
DR VEuPathDB; FungiDB:CIMG_04361; -.
DR InParanoid; J3KDB5; -.
DR OMA; TMHQKYN; -.
DR OrthoDB; 2643493at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR CDD; cd11887; SH3_Bbc1; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035552; Mti1_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR PANTHER; PTHR45929:SF3; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..67
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 43..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..111
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..148
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..443
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..618
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..706
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..765
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..820
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1176 AA; 128688 MW; B4A6046AEC2DC428 CRC64;
MPAVPFTVKG IFEYTSDHED DLTFSIGQII TVTAEEDEEW YYGEYTDEAG TKKEGIFPRN
FVERYEPPAP PRPSRPSKPK KDSEHPLHAE AVPQPPQVAS SPAPPSPEFE APPSIERETE
SKPPHPVPPP PAEIHILAAP PPPQAPSQQQ PTSATQRTEF KPPPPPIAEK PTGTSFRDRI
AAFNKPAAAP IAPFNPSAAT LNSSAFIKKP FVAPPPSKNA YVPMPVEAPP QRVYKREEDP
EVMEPHQERL ATDRSPPPPP EAADDEDKPK PTSLKERIAL LQKQQLEQAA RHAEAAQKKE
KPKKPPPKKR VEPQEAPDHV DSVPGAELER TDTSETAKES HTGVEHRDDT GPPQHRAPIL
PSTMSAAHPS PEHTSDPNDA DHSGTGDTEE AEETSASKED GDEKLAKHGL GMTQGEQEDQ
IDQGGAKGED VEEEEEEEEE EDIDPEIKRR MELRDRMAKM SGGMGMMGMF GPPPGIPGMS
GSGYKKPQPS HSASAEAKSP DEERSTPAYA TPVPVMVLPG MQSRKQESIK SPTEIKGDEI
DTQLTTAVQT PKMTTEEADV HPSQPKMQRA PPPPPQEERS PPLPPGHSRP VLPPMPGDRP
ISPSPPPESR PAPLPPTRRT MSPSLGEESD DELSAAPGNL QAESQSSDGC TAAVLPDRKN
DAAPPLRPPT SEKRLSHPPP VPQVLPTLPS AAQTRPPPPP PPFPVSRKST NDSRMSVRTQ
TGLPGHDTEE EITEYEGDYD TDIASSAKHK DALKAHGRDS SVDEGTITDE FSTQSPQSPV
DIRPPPPPTM APRAAPPPPP RSMRQSIDMP RMPPPPIPPP KNHAHDEDEY DPYRYDTHPA
APPSRGAPTA TKSPSEEAGG EDFYPESSPR KSIHSSPPPN PPSLQSASRS QPSRGSVDLL
RSQSNTRRSM DIQRPPMEGY IASDVDLGEG TFWWTQPNTP PPVFQNRRDI MYEVEESSST
KRGGKTTISK DVYVLFMDYS QTIITVQFDS KNPGDVILEQ RHEAPPPRLR QDQLENAHAL
FGSRLSESVA SKQNTIVGDG TSYSLVQSLL TPFSDALLPV GSRAFGAAVY SNLANASVQQ
YDEIRPGDIV TFRNARFQGH RGTMHQKYNV EVGKPDHVGV VVDWDGTKKK IRAWEQGRES
KKVKIESFKL GDLKSGECRV WRVMPRSWVG WDGEKS
//
