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Database: UniProt/TrEMBL
Entry: J3KI71_COCIM
LinkDB: J3KI71_COCIM
Original site: J3KI71_COCIM 
ID   J3KI71_COCIM            Unreviewed;       490 AA.
AC   J3KI71;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 2.
DT   05-JUL-2017, entry version 26.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   ORFNames=CIMG_00997 {ECO:0000313|EMBL:EAS35643.3};
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Coccidioides.
OX   NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS35643.3, ECO:0000313|Proteomes:UP000001261};
RN   [1] {ECO:0000313|Proteomes:UP000001261}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA   Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA   Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA   Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA   Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens
RT   Coccidioides and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2] {ECO:0000313|Proteomes:UP000001261}
RP   GENOME REANNOTATION.
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672880}.
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DR   EMBL; GG704911; EAS35643.3; -; Genomic_DNA.
DR   RefSeq; XP_001247226.1; XM_001247225.2.
DR   ProteinModelPortal; J3KI71; -.
DR   STRING; 246410.XP_001247226.1; -.
DR   EnsemblFungi; EAS35643; EAS35643; CIMG_00997.
DR   GeneID; 4565527; -.
DR   KEGG; cim:CIMG_00997; -.
DR   EuPathDB; FungiDB:CIMG_00997; -.
DR   eggNOG; ENOG410J0H0; Eukaryota.
DR   eggNOG; ENOG4111ITA; LUCA.
DR   InParanoid; J3KI71; -.
DR   KO; K00844; -.
DR   OrthoDB; EOG092C4JPH; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008865; F:fructokinase activity; IEA:EnsemblFungi.
DR   GO; GO:0004340; F:glucokinase activity; IEA:EnsemblFungi.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0019158; F:mannokinase activity; IEA:EnsemblFungi.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006000; P:fructose metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:EnsemblFungi.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001261};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672871,
KW   ECO:0000313|EMBL:EAS35643.3};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW   Transferase {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       27    221       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      227    466       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   490 AA;  54461 MW;  64D1F29C94EC72A7 CRC64;
     MTVTAPRRRP SRKGSMADMP KDLLEQVKEL EELFTVDQAR LKKIVDHFVK ELEKGLSVQG
     GNIPMNVTWV MGFPTGHEHG TFLALDMGGT NLRVCEIFLC EKKGEFDITQ SKYRIPEELK
     SGNADDLWEY IADCVQQFIE YHHEEENLPD LPLGFTFSYP ATQEYIDHGV LQRWTKGFDI
     DGVEGEDVVP MLEAALAKRG LPIKVAALIN DTTGTLIASA YTDPEMRIGC IFGTGVNAAY
     MENAGSIPKI AHYNLPPDMP IAINCEYGAF DNERVVLPLT QYDVVIDRDS PRPGQQAFEK
     MTAGLYLGEI FRLVLLDLID NKGNLIFEGQ DVSSLRKPYC LDSSFLAYIE EDPFENLSET
     RDLFERTLGI KATKPELELC RRLAELVGTR AARLSACGVA AICKKKNIKS CHVGADGSVF
     NKYPHFKARG AKALREILDW ADDEEDKVII CSAEDGSGVG AALIAALTLE RVKQGNLAGI
     RKTDTMKKLL
//
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