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Database: UniProt/TrEMBL
Entry: J3KJA5_COCIM J3KJJ8_COCIM
LinkDB: J3KJA5_COCIM J3KJJ8_COCIM
Original site: J3KJA5_COCIM J3KJJ8_COCIM 
ID   J3KJA5_COCIM            Unreviewed;      1080 AA.
AC   J3KJA5;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 2.
DT   24-JAN-2024, entry version 49.
DE   SubName: Full=Linoleate diol synthase {ECO:0000313|EMBL:EAS36125.3};
GN   ORFNames=CIMG_01479 {ECO:0000313|EMBL:EAS36125.3};
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS36125.3, ECO:0000313|Proteomes:UP000001261};
RN   [1] {ECO:0000313|Proteomes:UP000001261}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2] {ECO:0000313|Proteomes:UP000001261}
RP   GENOME REANNOTATION.
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
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DR   EMBL; GG704911; EAS36125.3; -; Genomic_DNA.
DR   RefSeq; XP_001247708.1; XM_001247707.2.
DR   AlphaFoldDB; J3KJA5; -.
DR   STRING; 246410.J3KJA5; -.
DR   GeneID; 4567715; -.
DR   KEGG; cim:CIMG_01479; -.
DR   VEuPathDB; FungiDB:CIMG_01479; -.
DR   InParanoid; J3KJA5; -.
DR   OMA; KIQWDGD; -.
DR   OrthoDB; 3322316at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd20612; CYP_LDS-like_C; 1.
DR   CDD; cd09817; linoleate_diol_synthase_like; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   InterPro; IPR034812; Ppo-like_N.
DR   PANTHER; PTHR11903; PROSTAGLANDIN G/H SYNTHASE; 1.
DR   PANTHER; PTHR11903:SF37; PSI-PRODUCING OXYGENASE A; 1.
DR   Pfam; PF03098; An_peroxidase; 1.
DR   Pfam; PF00067; p450; 1.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR   PROSITE; PS50292; PEROXIDASE_3; 1.
PE   4: Predicted;
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT   REGION          33..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         378
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ   SEQUENCE   1080 AA;  121595 MW;  87E6EE3F00B60131 CRC64;
     MVLDSSSRRG VLDDLAKYFP HFGGIANGSL WPITPDSGHH SPSQGPTGGL LQDLGSLDVK
     DVGTVLELIK NTASGAPVED KRYIMERVIQ LASSLPSTSH NRTTITNTLL AQLWNDLSHP
     PVSYLGRDVI YRQADGSYNN IYWPQIGKAG SNYARSVQPK SIQPASRPDP GLLFDGLLAR
     QQFKEHPNKL SSVLFYLAAL IIHDLFRTDP TDSSRNMTSS YLDLSPLYGC NQEEQNQVRT
     FKDGKLRPDC FSERRVFGFP PGVGVLLIMF NRFHNYVVQN LAAINENNRF RKPDESDADA
     CAKYDNDLFQ TGRLITCGLY INIILKDYVR NILNINQTDS DWSLDPRSDV KELLSHKPVQ
     EAGGNMVAAE FNLVYRWHSC LSDRDDRWMQ EIFEKALDGK DLDTIGMPEF LGKIRKLQSS
     IPDDPMLRPF ANLERQSNGS YDDNDLVKIL TESIEDCAGS FGARHVPKVL RSVEILGILQ
     ARSWNLSSLN EFRKYFNLAP HTSFEDINSD PEVVEQLRHF YGHPDNVELY PGIVVEEGKP
     RIVPGSGLCA SYTISRTVLS DAVALVRGDR FYTVDYTPQN LTNWGYNEAN YDMTVNNGHI
     FHKLILRAFP RHFKPDSVYA HFPFVIPSEN KKILSDLGLA EKYSWERPGA VPHPTVILSH
     GACNAILHNK EDFKITWGEK VKHIMARNSI PYGADFMLSG DEQVHEDSRQ MMKKALYIED
     WCGQVRAFYE RITLELLHSK SHRISGVSQV DIVRDVANLA AIHFSSNIFL LPLKTEGLPH
     GVFTDTELYR SMALILNYIF YDVDPTQSFK LRERSRSESQ KLGELVMLNV QAISKTGFIG
     SIIDKLHGNE ALANYGVHMI RRLLATQMPI DELVWTHILP TAGGMVANQA QLFSQCLDFY
     LSEQGSRHWP EIRRLAGLNT KEADDLLLRY FLEGARIRST VALYRDVSKD CKVQDHGKEV
     NLHAGQRIIC NLMSACKDPE VFPEPDEVDL TRDLDSYIHL GVGPHECLGK GMVQIGLTTM
     LKVVGRLDNL RRAPGPQGQL HSIPGPGGIP LYMSEDESEV SPFPATMKVL WDGELPPLPQ
//
ID   J3KJJ8_COCIM            Unreviewed;       548 AA.
AC   J3KJJ8;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 2.
DT   24-JAN-2024, entry version 43.
DE   SubName: Full=Phosphotransferase enzyme family protein {ECO:0000313|EMBL:EAS36249.3};
GN   ORFNames=CIMG_01603 {ECO:0000313|EMBL:EAS36249.3};
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS36249.3, ECO:0000313|Proteomes:UP000001261};
RN   [1] {ECO:0000313|Proteomes:UP000001261}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2] {ECO:0000313|Proteomes:UP000001261}
RP   GENOME REANNOTATION.
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
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CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
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CC   ---------------------------------------------------------------------------
DR   EMBL; GG704911; EAS36249.3; -; Genomic_DNA.
DR   RefSeq; XP_001247832.2; XM_001247831.2.
DR   AlphaFoldDB; J3KJJ8; -.
DR   GeneID; 4567273; -.
DR   KEGG; cim:CIMG_01603; -.
DR   VEuPathDB; FungiDB:CIMG_01603; -.
DR   InParanoid; J3KJJ8; -.
DR   OMA; WLWNERQ; -.
DR   OrthoDB; 2282524at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   Gene3D; 3.90.1200.10; -; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   PANTHER; PTHR36091; ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR36091:SF2; APH DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01636; APH; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT   DOMAIN          62..178
FT                   /note="Aminoglycoside phosphotransferase"
FT                   /evidence="ECO:0000259|Pfam:PF01636"
FT   DOMAIN          306..341
FT                   /note="Aminoglycoside phosphotransferase"
FT                   /evidence="ECO:0000259|Pfam:PF01636"
SQ   SEQUENCE   548 AA;  61891 MW;  2DB395342DC96545 CRC64;
     MDQRQGDFID SKHDLDALNR FTSGRWLWNE RQQLAARYVK FNITKLLKLA AASIGSESCA
     EVVKLSEGQY NKVFQLTMHD GREVIAKLPN PNAGRLHFTT ASEVATMDFL RNTLHLPVPK
     VHAWSSRASD NAVGAEYIIM EKQAGTMLSD MWETMRGKQK AQIVKQIVDI EKTIASTKFT
     KLGALYYKRD LPSSDHDTVL YVDRAGNEVH TEEFGIGPTN HRSFFDFGRG ELDIDRGPWS
     TTTAYLEAVA HREISCVDMG LRYPLMPEGL FYGPGQYQPS ASKKLSALRN YLKVAPYVLP
     DNRAIHVPVL WHGDLHLQNI FIDPAEPTRI VGIIDWQSVS ICPLFMQVTM PGFLDYNGPI
     PKELGRVSLP PNFGFMTPDE QRKAKELRQA QTLHNLYLAL SRQINPTAFQ AIKGQDSLRH
     QVSVVPGLTI TDSEPCLTGL LREVEKGWST IVGNGPDGLP SKHCPLRFSA AEVEQQEHDE
     KLWAQGVDLM NHFINETGCF KHWDGRVSNE DYEVSKRQLA EGIESFLSRE ARSQEERKAW
     LKALPFVD
//
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