ID J9W7H7_MYCIP Unreviewed; 755 AA.
AC J9W7H7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943};
GN ORFNames=MIP_01544 {ECO:0000313|EMBL:AFS13064.1};
OS Mycobacterium indicus pranii (strain DSM 45239 / MTCC 9506).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=1232724 {ECO:0000313|EMBL:AFS13064.1, ECO:0000313|Proteomes:UP000007329};
RN [1] {ECO:0000313|EMBL:AFS13064.1, ECO:0000313|Proteomes:UP000007329}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MTCC 9506 {ECO:0000313|EMBL:AFS13064.1};
RX PubMed=17912347; DOI=10.1371/journal.pone.0000968;
RA Ahmed N., Saini V., Raghuvanshi S., Khurana J.P., Tyagi A.K., Tyagi A.K.,
RA Hasnain S.E.;
RT "Molecular analysis of a leprosy immunotherapeutic bacillus provides
RT insights into Mycobacterium evolution.";
RL PLoS ONE 2:E968-E968(2007).
RN [2] {ECO:0000313|EMBL:AFS13064.1, ECO:0000313|Proteomes:UP000007329}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45239 / MTCC 9506 {ECO:0000313|Proteomes:UP000007329};
RX PubMed=22965120; DOI=10.1093/nar/gks793;
RA Saini V., Raghuvanshi S., Khurana J.P., Ahmed N., Hasnain S.E., Tyagi A.K.,
RA Tyagi A.K.;
RT "Massive gene acquisitions in Mycobacterium indicus pranii provide a
RT perspective on mycobacterial evolution.";
RL Nucleic Acids Res. 40:10832-10850(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002275; AFS13064.1; -; Genomic_DNA.
DR RefSeq; WP_008253977.1; NC_018612.1.
DR AlphaFoldDB; J9W7H7; -.
DR KEGG; mid:MIP_01544; -.
DR PATRIC; fig|1232724.3.peg.1091; -.
DR HOGENOM; CLU_008325_2_1_11; -.
DR Proteomes; UP000007329; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR CDD; cd04863; MtLigD_Pol_like; 1.
DR CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR014146; LigD_ligase_dom.
DR InterPro; IPR014144; LigD_PE_domain.
DR InterPro; IPR014145; LigD_pol_dom.
DR InterPro; IPR033649; MtLigD_Pol-like.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR NCBIfam; TIGR02777; LigD_PE_dom; 1.
DR NCBIfam; TIGR02778; ligD_pol; 1.
DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR PANTHER; PTHR42705:SF2; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF13298; LigD_N; 1.
DR Pfam; PF21686; LigD_Prim-Pol; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AFS13064.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 543..665
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT REGION 736..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 755 AA; 84351 MW; 48B07435B752DEBD CRC64;
MSPTAGPRVK LTNAEKVLYP ATGTTKSDIF DYYTRIAEVM IPHIAGRPAT RKRWPNGVEQ
ESFFEKQLAA SAPDWLPRAS VTHRSGTTTY PIIDDPTGLA WIAQQAALEV HVPQWRFVAE
WTRSRAEELK PGPATRLVFD LDPGEGVTMA QMSKVARAVR DLIAGIGLRT FPLTSGSKGL
HLYAPLDEPV SSKGATVLAK RVAQQLEKTM PKLVTSTMTK SLRAGKIFLD WSQNNGSKTT
IAPYSLRGRE HPTVAAPRTW DELDDPSLRQ LRYDEVLSRV ARDGDLLAEL DEDAPVPDRL
TKYRSMRDAS KTPEPVPAAK PAVGQGNTFV IQEHHARRLH YDFRLERDGV LVSWAVPKNL
PETTSVNHLA VHTEDHPLEY GGFEGVIPKG EYGAGKVIIW DSGTYDAEKF LDDEVIVNLH
GSKISGRYAL IQTNGDQWLA HRMKDQKVFE FDTIAPMLAT HGSVTALKAG QWAFEGKWDG
YRLLIEADHG AFRVRSRRGR EVTQEYRELR WLADDLADHH VVLDGEAVVL DSSGVPNFHE
MQNRGRGSRV EFWAFDLLYL DGRSLLRARY RDRRKLLEML AAGSRLIVPD LLPGDGREAL
EHSAERGWEG VIAKKRDSTY QPGRRSSSWI KDKHWNTQEV VIGGWKAGEG GRSSGIGSLL
MGIPTAGGLH FAGRVGTGFT DRDLANLKKT LAPLHTDESP FDPPLPRSEA RGVTYVRPEL
VGEVRYSEWT PDDRLRQSSW RGLRPDKEAS EVVRE
//