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Database: UniProt/TrEMBL
Entry: K1R0N9_CRAGI
LinkDB: K1R0N9_CRAGI
Original site: K1R0N9_CRAGI 
ID   K1R0N9_CRAGI            Unreviewed;       915 AA.
AC   K1R0N9;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   25-OCT-2017, entry version 25.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=CGI_10028881 {ECO:0000313|EMBL:EKC42907.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Bivalvia; Pteriomorphia;
OC   Ostreoida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC42907.1, ECO:0000313|Proteomes:UP000005408};
RN   [1] {ECO:0000313|EMBL:EKC42907.1, ECO:0000313|Proteomes:UP000005408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC42907.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W.H., Paps J.,
RA   Zhu Y., Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J.,
RA   Wen B., Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D.,
RA   Xu Z., Liu Y., Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B.,
RA   Cheng P., Jiang X., Li J., Fan D., Wang W., Fu W., Wang T., Wang B.,
RA   Zhang J., Peng Z., Li Y., Li N., Wang J., Chen M., He Y., Tan F.,
RA   Song X., Zheng Q., Huang R., Yang H., Du X., Chen L., Yang M.,
RA   Gaffney P.M., Wang S., Luo L., She Z., Ming Y., Huang W., Zhang S.,
RA   Huang B., Zhang Y., Qu T., Ni P., Miao G., Wang J., Wang Q.,
RA   Steinberg C.E.W., Wang H., Li N., Qian L., Zhang G., Li Y., Yang H.,
RA   Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; JH817099; EKC42907.1; -; Genomic_DNA.
DR   RefSeq; XP_011438541.1; XM_011440239.2.
DR   EnsemblMetazoa; EKC42907; EKC42907; CGI_10028881.
DR   GeneID; 105336061; -.
DR   KEGG; crg:105336061; -.
DR   InParanoid; K1R0N9; -.
DR   KO; K10777; -.
DR   OMA; HMCPSTK; -.
DR   OrthoDB; EOG091G03K0; -.
DR   Proteomes; UP000005408; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR021536; DNA_ligase_IV_dom.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF11411; DNA_ligase_IV; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005408};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:EKC42907.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005408}.
FT   DOMAIN      358    492       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      659    748       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      810    914       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   915 AA;  104115 MW;  158F266C47E0E2E5 CRC64;
     MDEEDVDTKP ELTVASQVSF AELCGLLEKI SKTHGNEKKK AVLGTFVEKW REFHQELHKD
     NPDTTDSFYA AMRLLVPQLE KQRAAYGIKE HMLAKLLIEV LCLGKDSADS NRLLNFKAPK
     AAKGDAGDFA AVAYFVLKNR CPEKGTLTIQ EVNNCLDGIA TNNAAKKKDL VRKNILKLLT
     NMSAIELKWL IRMIVKELKV GLSQTSVFSV YHPDAEEFYN VNNNLEKVCR MLRDKSVRVH
     EIGIEIFSPF TPMLGERAAP DQVEKLMDGK PYIIETKFDG ERILLHKQEG EYKYFSRSGN
     EYTSTFGSNR YDGNMTPFIH ECFQSSVKSC ILDGEMIGYD AATKTFATKA MNTDIKHQRE
     EGYQPCYYAF DLIMLNGRVL TNQPLKERLE LLKTVFKEEE GRLFLSKHTE ANTNQDCAEA
     LNEAIDGREE GIMVKKPDSV YRPNTRKGGW FKIKPEYVGG LMDELDVLVV GGFFGVGHRS
     GMMSHFLCAL AVPEEDGSHP TVFHSFCKVG SGYSKKELAE FNKKLAEHWK VFNKKNPPSS
     IILASGFKEK PDAYIEPKNS CIVQIKAAEV IDSERFKTGF TLRFPRVEKF RDDKAWYECM
     TVPEVQEMKD RAGGKLAGGK VELREEEEPT KKKRKVVTHV IRPTLGAQFQ AADLSDVTQT
     SKIFEGKEFC VINGPSSLSK AAIEKKVAEY GGSVVQNPGS TTFCVLADKI VMRVTNLMKR
     DLYDIVKVDW FKRCLDAQTF IPWAPADMIH TSAKTQMALK KDYDEFGDSY MQDTTPDQLK
     YTFQHMDNSE ISISTDEMAE LEEKYFPDDS PYGLFRTCRF YLDNKLVIGD PSTQIKDSPL
     EFLALELRFF GGTVSDSLDK KVSHVMVDKR DLSRVQELKQ ERRKRSRKFH IVNEDWLRQC
     LEEGSLCSER QFEPS
//
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