GenomeNet

Database: UniProt/TrEMBL
Entry: K7D2K6_PANTR
LinkDB: K7D2K6_PANTR
Original site: K7D2K6_PANTR 
ID   K7D2K6_PANTR            Unreviewed;      2564 AA.
AC   K7D2K6; H2QMH8;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   25-APR-2018, entry version 40.
DE   SubName: Full=SET domain containing 2 {ECO:0000313|EMBL:JAA26582.1, ECO:0000313|Ensembl:ENSPTRP00000025629};
GN   Name=SETD2 {ECO:0000313|EMBL:JAA26582.1,
GN   ECO:0000313|Ensembl:ENSPTRP00000025629, ECO:0000313|VGNC:VGNC:2562};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA26582.1};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000025629, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000025629}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:JAA26582.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA07554.1}, Skeletal muscle
RC   {ECO:0000313|EMBL:JAA38788.1}, Skin {ECO:0000313|EMBL:JAA26582.1}, and
RC   Smooth vascular {ECO:0000313|EMBL:JAA18634.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from
RT   NextGen mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00574581}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AACZ04000295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABC01003784; JAA07554.1; -; mRNA.
DR   EMBL; GABF01003511; JAA18634.1; -; mRNA.
DR   EMBL; GABD01006518; JAA26582.1; -; mRNA.
DR   EMBL; GABE01005951; JAA38788.1; -; mRNA.
DR   RefSeq; XP_016796414.1; XM_016940925.1.
DR   STRING; 9598.ENSPTRP00000025629; -.
DR   Ensembl; ENSPTRT00000027789; ENSPTRP00000025629; ENSPTRG00000014866.
DR   GeneID; 460331; -.
DR   KEGG; ptr:460331; -.
DR   CTD; 29072; -.
DR   VGNC; VGNC:2562; SETD2.
DR   eggNOG; KOG4442; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   GeneTree; ENSGT00780000121845; -.
DR   KO; K11423; -.
DR   OMA; FIGHDSH; -.
DR   OrthoDB; EOG091G040P; -.
DR   TreeFam; TF106477; -.
DR   Proteomes; UP000002277; Chromosome 3.
DR   Bgee; ENSPTRG00000014866; -.
DR   GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043014; F:alpha-tubulin binding; IEA:Ensembl.
DR   GO; GO:0046975; F:histone methyltransferase activity (H3-K36 specific); IEA:Ensembl.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0035441; P:cell migration involved in vasculogenesis; IEA:Ensembl.
DR   GO; GO:0060977; P:coronary vasculature morphogenesis; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
DR   GO; GO:0060669; P:embryonic placenta morphogenesis; IEA:Ensembl.
DR   GO; GO:0035987; P:endodermal cell differentiation; IEA:Ensembl.
DR   GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR   GO; GO:0097676; P:histone H3-K36 dimethylation; IEA:Ensembl.
DR   GO; GO:0097198; P:histone H3-K36 trimethylation; IEA:Ensembl.
DR   GO; GO:0048332; P:mesoderm morphogenesis; IEA:Ensembl.
DR   GO; GO:1902850; P:microtubule cytoskeleton organization involved in mitosis; IEA:Ensembl.
DR   GO; GO:0006298; P:mismatch repair; IEA:Ensembl.
DR   GO; GO:0001763; P:morphogenesis of a branching structure; IEA:Ensembl.
DR   GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR   GO; GO:0034728; P:nucleosome organization; IEA:Ensembl.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; IEA:Ensembl.
DR   GO; GO:0060039; P:pericardium development; IEA:Ensembl.
DR   GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
DR   GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
DR   GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; IEA:Ensembl.
DR   GO; GO:0010793; P:regulation of mRNA export from nucleus; IEA:Ensembl.
DR   GO; GO:1905634; P:regulation of protein localization to chromatin; IEA:Ensembl.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0034340; P:response to type I interferon; IEA:Ensembl.
DR   GO; GO:0048864; P:stem cell development; IEA:Ensembl.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:Ensembl.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 1.10.1740.100; -; 1.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR013257; SRI.
DR   InterPro; IPR038190; SRI_sf.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF08236; SRI; 1.
DR   Pfam; PF00397; WW; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF51045; SSF51045; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675};
KW   Nucleus {ECO:0000256|SAAS:SAAS00574642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533}.
FT   DOMAIN     1494   1548       AWS. {ECO:0000259|PROSITE:PS51215}.
FT   DOMAIN     1550   1667       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN     1674   1690       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   DOMAIN     2389   2422       WW. {ECO:0000259|PROSITE:PS50020}.
FT   COILED     1738   1758       {ECO:0000256|SAM:Coils}.
FT   COILED     2122   2142       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2564 AA;  287491 MW;  644DE6B8CD6EE8A5 CRC64;
     MKQLQPQPPP KMGDFYDPEH PTPEEEENEA KIENVQKTGF IKGPMFKGVA SSRFLPKGTK
     TKVNLEEQGR QKVSFSFSLT KKTLQNRFLT ALGNEKQSDT PNPPAVPLQV DLTPKMKMEI
     GDTLSTAEES SPPKSRVELG KIHFKKHLLH VTSRPLLATT TAVASPPTHA APLPAVIAES
     TTVDSPPSSP PPPPPPAQAT TLSSPAPVTE PVALPHTPIT VLMAAPVPLP VDVAVRSLKE
     PPIIIVPESL EADTKQDTVS NSSEEHVTQI LNEQADISSK KEDSHIGKDE EIPDSSKISL
     SCKKTGSKKK SSQSEGIFLG SESDEDSVRT SSSQRSHDLK ISASIEKERD FKKSSAPLKS
     EDLGKSSRSK TDRDDKYFSY SKLERDTRYV SSRCRSERER RRSRSHSRSE RGSRTNLSYS
     RSERSHYYDS DRRYHRSSPY RERTRYSRPY TDNRARESSD SEEEYKKTYS RRTSSHSSSY
     RDLRTSSYSK SDRDCKTETS YLEIERRGKY SSKLERESKR TSENEAIKRC CSPPNELGFR
     RGSSYSKHDS SASRYKSTLS KPIPKSDKFK NSFCCTELNE EIKQSHSFSL QTPCSKGSEL
     RMINKNPERE KAGSPAPSNR LNDSPTLKKL DELPIFKSEF ITHDSHDSIK ELDSLSKVKN
     DQLRSFCPIE LNINGSPGAE SDLATFCTSK TDAVLITSDD SVTGSELSPL VKACMLSSNG
     FQNISRCKEK DLDDTCMLHK KSESPFRETE PLVSPHQDKL MSLPVMTVDY SKTVVKEPVD
     TRVSCCKTKD SDIYCTLNDS NPSLCNSEAE NIEPSVMKIS SNSFMNVHLE SKPVICDSRN
     LTDHSKFACE EYKQSIGSTS SASVNHFDDL YQPIGSSGIA SSLQSLPPGI KVDSLTLLKC
     GENTSPVLDA VLKSKKSSEF LKHAGKETIV EVGSDLPDSG KGFASRENRR NNGLSGKCLQ
     EAQEEGNSIL PERRGRPEIS LDERGEGGHV HTSDDSEVVF SSCDLNLTME DSDGVTYALK
     CDSSGHAPEI VSTVHEDYSG SSESSNDESD SEDTDSDDSS IPRNRLQSVV VVPKNSTLPM
     EETSPCSSRS SQSYRHYSDH WEDERLESRR HLYEEKFESI ASKACPQTDK FFLHKGTEKN
     PEISFTQSSR KQIDNHLPEL SHPQSDGVDS TSHTDVKSDP LGHPNSEETV KAKIPSRQQE
     ELPIYSSDFE DVPNKSWQQT TFQNRPDSRL GKTELSFSSS CEIPHVDGLH SSEELRNLGW
     DFSQEKPSTT YQQPDSSYGA CGGHKYQQNA EQYGGTRDYW QGNGYWDPRS GRPPGTGVVY
     DRTQGQVPDS LTDDREEEEN WDQQDGSHFS DQSNKFLLSL QKDKGSVQAP EISSNSIKDT
     LAVNEKKDFS KNLEKNDIKD RGPLKKRRQE IESDSESDGE LQDRKKVRVE VEQGETLVPP
     GSALVGPSCV MDDFRDPQRW KECAKQGKMP CYFDLIEENV YLTERKKNKS HRDIKRMQCE
     CTPLSKDERA QGEIACGEDC LNRLLMIECS SRCPNGDYCS NRRFQRKQHA DVEVILTEKK
     GWGLRAAKDL PSNTFVLEYC GEVLDHKEFK ARVKEYARNK NIHYYFMALK NDEIIDATQK
     GNCSRFMNHS CEPNCETQKW TVNGQLRVGF FTTKLVPSGS ELTFDYQFQR YGKEAQKCFC
     GSANCRGYLG GENRVSIRAA GGKMKKERSR KKDSVDGELE ALMENGEGLS DKNQVLSLSR
     LMVRIETLEQ KLTCLELIQN THSQSCLKSF LERHGLSLLW IWMAELGDGR ESNQKLQEEI
     IKTLEHLPIP TKNMLEESKV LPIIQRWSQT KTAVPPLSEG DGYSSENTSR AHTPLNTPDP
     STKLSTEADT DTPKKLMFRR LKIISENSMD SAISDATSEL EGKDGKEDLD QLENVPVEEE
     EELQSQQLLP QQLPECKVDS ETNIEASKLP TSEPEADAEI EPKESNGTKL EEPINEETPS
     QDEEEGVSDV ESERSQEQPD KTVDISDLAT KLLDSWKDLK EVYRIPKKSQ TEKENTTTER
     GRDAVGFRDQ TPAPKTPNRS RERDPDKQTQ NKEKRKRRSS LSPPSSAYER GTKRPDDRYD
     TPTSKKKVRI KDRNKLSTEE RRKLFEQEVA QREAQKQQQQ MQNLGMTSPL PYDSLGYNAP
     HHPFAGYPPG YPMQAYVDPS NPNAGKVLLP TPSMDPVCSP APYDHAQPLV GHSTEPLSAP
     PPVPVVPHVA APVEVSSSQY VAQSDGVVHQ DSSVAVLPVP APGPVQGQNY SVWDSNQQSV
     SVQQQYSPAQ SQATIYYQGQ TCPTVYGVTS PYSQTTPPIV QSYAQPSLQY IQGQQIFTAH
     PQGVVVQPAA AVTTIVAPGQ PQPLQPSEMV VTNNLLDLPP PSPPKPKTIV LPPNWKTARD
     PEGKIYYYHV ITRQTQWDPP TWESPGDDAS LEHEAEMDLG TPTYDENPMK ASKKPKTAEA
     DTSSELAKKS KEVFRKEMSQ FIVQCLNPYR KPDCKVGRIT TTEDFKHLAR KLTHGVMNKE
     LKYCKNPEDL ECNENVKHKT KEYIKKYMQK FGAVYKPKED TELE
//
DBGET integrated database retrieval system