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Database: UniProt/TrEMBL
Entry: K7DFV5_PANTR
LinkDB: K7DFV5_PANTR
Original site: K7DFV5_PANTR 
ID   K7DFV5_PANTR            Unreviewed;       917 AA.
AC   K7DFV5;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   25-OCT-2017, entry version 33.
DE   SubName: Full=Hexokinase 1 {ECO:0000313|EMBL:JAA32777.1};
GN   Name=HK1 {ECO:0000313|EMBL:JAA32777.1};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA32777.1};
RN   [1] {ECO:0000313|EMBL:JAA32777.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Skin {ECO:0000313|EMBL:JAA32777.1}, and Smooth vascular
RC   {ECO:0000313|EMBL:JAA17589.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from
RT   NextGen mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|SAAS:SAAS00672880}.
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DR   EMBL; GABF01004556; JAA17589.1; -; mRNA.
DR   EMBL; GABD01000323; JAA32777.1; -; mRNA.
DR   RefSeq; XP_009456875.1; XM_009458600.2.
DR   GeneID; 450505; -.
DR   KEGG; ptr:450505; -.
DR   CTD; 3098; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   eggNOG; COG5026; LUCA.
DR   KO; K00844; -.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:InterPro.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 4.
DR   Pfam; PF00349; Hexokinase_1; 2.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 2.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00672869};
KW   Glycolysis {ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|SAAS:SAAS00672871, ECO:0000313|EMBL:JAA32777.1};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00672883};
KW   Transferase {ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       22    219       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      225    459       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
FT   DOMAIN      470    667       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      673    907       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   917 AA;  102414 MW;  A0DE33B0DC6FBB9E CRC64;
     MIAAQLLAYY FTELKDDQVK KIDKYLYAMR LSDETLIDIM TRFRKEMKNG LSRDFNPTAT
     VKMLPTFVRS IPDGSEKGDF IALDLGGSSF RILRVQVNHE KNQNVHMESE VYDTPENIVH
     GSGSQLFDHV AECLGDFMEK RKIKDKKLPV GFTFSFPCQQ SKIDEAILIT WTKRFKASGV
     EGADVVKLLN KAIKKRGDYD ANIVAVVNDT VGTMMTCGYD DQHCEVGLII GTGTNACYME
     ELRHIDLVEG DEGRMCINTE WGAFGDDGSL EDIRTEFDRE IDRGSLNPGK QLFEKMVSGM
     YLGELVRLIL VKMAKEGLLF EGRITPELLT RGKFNTSDVS AIEKNKEGLH NAKEILTRLG
     VEPSDDDCVS VQHVCTIVSF RSANLVAATL GAILNRLRDN KGTPRLRTTV GVDGSLYKTH
     PQYSRRFHKT LRRLVPDSDV RFLLSESGSG KGAAMVTAVA YRLAEQHRQI EETLAHFHLT
     KDMLLEVKKR MRAEMELGLR KQTHNNAAVK MLPSFVRRTP DGTENGDFLA LDLGGTNFRV
     LLVKIRSGKK RTVEMHNKIY AIPIEIMQGT GEELFDHIVS CISDFLDYMG IKGPRMPLGF
     TFSFPCQQTS LDAGILITWT KGFKATDCVG HDVVTLLRDA IKRREEFDLD VVAVVNDTVG
     TMMTCAYEEP SCEVGLIVGT GSNACYMEEM KNVETVEGDQ GQMCINMEWG AFGDNGCLDD
     IRTHYDRLVD EYSLNAGKQR YEKMISGMYL GEIVRNILID FTKKGFLFRG QISETLKTRG
     IFETKFLSQI ESDRLALLQV RAILQQLGLN STCDDSILVK TVCGVVSRRA AQLCGAGMAA
     VVDKIRENRG LDRLNVTVGV DGTLYKLHPH FSRIMHQTVK ELSPKCNVSF LLSEDGSGKG
     AALITAVGVR LRTEASS
//
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