ID K7G1K4_PELSI Unreviewed; 710 AA.
AC K7G1K4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN Name=GUCY1A2 {ECO:0000313|Ensembl:ENSPSIP00000014165.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000014165.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000014165.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGCU01089294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01089295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01089296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01089297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01089298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01089299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01089300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01089301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01089302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01089303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006123451.1; XM_006123389.2.
DR AlphaFoldDB; K7G1K4; -.
DR STRING; 13735.ENSPSIP00000014165; -.
DR Ensembl; ENSPSIT00000014231.1; ENSPSIP00000014165.1; ENSPSIG00000012663.1.
DR GeneID; 102444454; -.
DR KEGG; pss:102444454; -.
DR CTD; 2977; -.
DR eggNOG; KOG4171; Eukaryota.
DR GeneTree; ENSGT00940000157765; -.
DR HOGENOM; CLU_011614_5_0_1; -.
DR OMA; SLMLHYF; -.
DR OrthoDB; 2898719at2759; -.
DR TreeFam; TF351403; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0007263; P:nitric oxide mediated signal transduction; IEA:Ensembl.
DR GO; GO:0010750; P:positive regulation of nitric oxide mediated signal transduction; IEA:Ensembl.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655:SF7; GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2; 1.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 499..626
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 440..471
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 79892 MW; 33FD62D1BE1C3569 CRC64;
MARRKISSES FSSLGSDYLE TSPEEEGECP LSRLCWNGSR SPPGPLDPLA AAAARRAPRR
RRVNLDSLGE SISRLTAPTP QTIQQTLQRT LRYYEHQVIG YRDAEKNFHN ISNRCSYTDC
SGNDEAEDVS GILQCTANIL GLKLEEMQEK FGEEFFNICF DENERVLRAV GGTLQDFFNG
FDALLEHIRI SFGRQATLES PSFLCKELPE GNLMLHYFHP HHIVGFAMLG MIKAAAKKIY
HLEVEVEQIT NDKLYSEGSN PGNCSCLTFL IKERENANIT KALPRGSSQS PSDLRINIST
FCRAFPFHLM FDPNMLVLQL GEGLRKQLKC DTHKTLKFQD CFEIVSPKIS TTFERVLLRL
STPFVIRTKL EASGSENKDK VMEVKGQMIY VPESNSILFL GSPCVDKLDE LMGRGLHLSD
IPIHDATRDV ILVGEQAKAQ DGLKKRMDKL KATLERTHQA LEEEKKKTVD LLISIFPGDV
AQQLWQGQQV QARKFDDVTM LFSDIVGFTA VCAQCTPMQV ISMLNELYTR FDHQCGFLDI
YKVETIGDAY CVAAGLHRKS LCHAKPIALM ALKMMELSEE VLTPDGRPIK MRIGIHSGSV
LAGVVGVRMP RYCLFGNNVT LASKFESGSH PRRINVSPTT YQLLKNEENF TFIPRSREAL
PENFPKEIPG ICYFLEVTSD QKQPKPSITS ARVKKVSYNI GTMFLRETSL
//
