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Database: UniProt/TrEMBL
Entry: K9RV98_SYNP3
LinkDB: K9RV98_SYNP3
Original site: K9RV98_SYNP3 
ID   K9RV98_SYNP3            Unreviewed;       430 AA.
AC   K9RV98;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   28-MAR-2018, entry version 28.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   OrderedLocusNames=Syn6312_2351 {ECO:0000313|EMBL:AFY61461.1};
OS   Synechococcus sp. (strain ATCC 27167 / PCC 6312).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae;
OC   Synechococcus.
OX   NCBI_TaxID=195253 {ECO:0000313|EMBL:AFY61461.1, ECO:0000313|Proteomes:UP000010379};
RN   [1] {ECO:0000313|Proteomes:UP000010379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27167 / PCC 6312 {ECO:0000313|Proteomes:UP000010379};
RX   PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA   Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E.,
RA   Calteau A., Cai F., Tandeau de Marsac N., Rippka R., Herdman M.,
RA   Sivonen K., Coursin T., Laurent T., Goodwin L., Nolan M.,
RA   Davenport K.W., Han C.S., Rubin E.M., Eisen J.A., Woyke T., Gugger M.,
RA   Kerfeld C.A.;
RT   "Improving the coverage of the cyanobacterial phylum using diversity-
RT   driven genome sequencing.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
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DR   EMBL; CP003558; AFY61461.1; -; Genomic_DNA.
DR   RefSeq; WP_015125004.1; NC_019680.1.
DR   EnsemblBacteria; AFY61461; AFY61461; Syn6312_2351.
DR   KEGG; syne:Syn6312_2351; -.
DR   PATRIC; fig|195253.3.peg.2398; -.
DR   KO; K00627; -.
DR   OrthoDB; POG091H04EL; -.
DR   BioCyc; SSP195253:G1HCL-2280-MONOMER; -.
DR   Proteomes; UP000010379; Chromosome.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.559.10; -; 1.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:AFY61461.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010379};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423, ECO:0000256|SAAS:SAAS00100674};
KW   Pyruvate {ECO:0000313|EMBL:AFY61461.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010379};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:AFY61461.1}.
FT   DOMAIN        2     77       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN      132    171       Peripheral subunit-binding (PSBD).
FT                                {ECO:0000259|PROSITE:PS51826}.
SQ   SEQUENCE   430 AA;  44815 MW;  F332CD8B119C5B83 CRC64;
     MIREVFMPAL SSTMTEGKIV AWVKEPGDKV EKGETVVIVE SDKADMDVES FYEGFLAVIT
     VPAGSSAPVG ATIGLVAETE AEIAQAQAQA PSSPATSPPT PSSNGNSQSS NGSSVAPPII
     TISTPVASGR LVASPRAKKL AKDLKVDLKT LEGKGSGPHG RITMADVEAA VGKVVTPTIP
     QVPQAPVTLP TPANITPTPT VSPAALAGEV QPLTTLQNAV VRNMNASLQI PDFHVSYTIT
     TDGLDALYKQ IKSKGVTMTA LLAKAVALTL QKHPIINACY TEQGIQYKPN INIAIAVAMP
     GGGLITPVLK DADKVDIYTL SRTWKDLVER ARAKQLQPDE YNSGTFSLSN LGMFGVNGFD
     AILTPGQGAI MAVGGSKPTV VATKEGLIGV QSQMEVNITC DHRVIYGADA AAFLQDLAKL
     IATNPQALTL
//
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