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Database: UniProt/TrEMBL
Entry: K9XYL3_STAC7
LinkDB: K9XYL3_STAC7
Original site: K9XYL3_STAC7 
ID   K9XYL3_STAC7            Unreviewed;      2779 AA.
AC   K9XYL3;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   25-OCT-2017, entry version 33.
DE   SubName: Full=Long-chain-fatty-acid--CoA ligase, 6-deoxyerythronolide-B synthase {ECO:0000313|EMBL:AFZ37598.1};
DE            EC=2.3.1.94 {ECO:0000313|EMBL:AFZ37598.1};
DE            EC=6.2.1.3 {ECO:0000313|EMBL:AFZ37598.1};
GN   OrderedLocusNames=Sta7437_4121 {ECO:0000313|EMBL:AFZ37598.1};
OS   Stanieria cyanosphaera (strain ATCC 29371 / PCC 7437).
OC   Bacteria; Cyanobacteria; Pleurocapsales; Dermocarpellaceae; Stanieria.
OX   NCBI_TaxID=111780 {ECO:0000313|EMBL:AFZ37598.1, ECO:0000313|Proteomes:UP000010473};
RN   [1] {ECO:0000313|Proteomes:UP000010473}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29371 / PCC 7437 {ECO:0000313|Proteomes:UP000010473};
RX   PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA   Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E.,
RA   Calteau A., Cai F., Tandeau de Marsac N., Rippka R., Herdman M.,
RA   Sivonen K., Coursin T., Laurent T., Goodwin L., Nolan M.,
RA   Davenport K.W., Han C.S., Rubin E.M., Eisen J.A., Woyke T., Gugger M.,
RA   Kerfeld C.A.;
RT   "Improving the coverage of the cyanobacterial phylum using diversity-
RT   driven genome sequencing.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00258}.
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DR   EMBL; CP003653; AFZ37598.1; -; Genomic_DNA.
DR   RefSeq; WP_015195252.1; NC_019748.1.
DR   ProteinModelPortal; K9XYL3; -.
DR   EnsemblBacteria; AFZ37598; AFZ37598; Sta7437_4121.
DR   KEGG; scs:Sta7437_4121; -.
DR   PATRIC; fig|111780.3.peg.4271; -.
DR   OMA; HLVRHPY; -.
DR   OrthoDB; POG091H06Z6; -.
DR   Proteomes; UP000010473; Chromosome.
DR   GO; GO:0102391; F:decanoate--CoA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   Gene3D; 1.10.1200.10; -; 2.
DR   Gene3D; 3.30.70.250; -; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR000639; Epox_hydrolase-like.
DR   InterPro; IPR032821; KAsynt_C_assoc.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   PRINTS; PR00111; ABHYDROLASE.
DR   PRINTS; PR00412; EPOXHYDRLASE.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 2.
DR   SUPFAM; SSF47336; SSF47336; 2.
DR   SUPFAM; SSF51735; SSF51735; 2.
DR   SUPFAM; SSF52151; SSF52151; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   SUPFAM; SSF55048; SSF55048; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000313|EMBL:AFZ37598.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010473};
KW   Ligase {ECO:0000313|EMBL:AFZ37598.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010473};
KW   Transferase {ECO:0000313|EMBL:AFZ37598.1}.
FT   DOMAIN      606    675       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     2064   2133       Carrier. {ECO:0000259|PROSITE:PS50075}.
SQ   SEQUENCE   2779 AA;  308436 MW;  6C05B31FAB519704 CRC64;
     MGGIKERSRL SKQYTFVEVL AERVAKQPEQ TAFTFLQDGE TELDSLTYQQ LEQQARAIAF
     RLQENHAQGK RALLLYQPGL EFISAFLGCL YAGVIAVPAY PPRANRSIER LLAIVTDAEA
     TFALTTQALQ EKIETKFQEN NQTEIQFIAT DTIEIQLASN WRKPNLTEDT LAFLQYTSGS
     TGNPKGVMVS HSNIIANSLS INRCFQNTPE HIGVSWLPPY HDMGLIGCIL QPIYVGVSMY
     MMAPVSFLQR PYRWLQAISK YRANTSGGPN FAYDLCVSQI TPEQRDTLDL SCWELAFSGA
     EPVRAETIEQ FSKYFSSCGF KQAAFYPCYG MAESTLLITG GNKQAEPVLK SFDKLAIEEN
     RAVAPTDSEM ATALVGCGQN IQQQQLILVN TDTFTQCSEG EIGEIWVNSA SVAQGYWRNR
     ELTETIFQAS LATGEKPWLR TGDLGFLQAG ELFVTGRLKD LIIIRGRNYY PQDIELTVDN
     AHPAVRAGNS AAFAVEIEGE EKLVIVQEIE RSYLRKLNVT AVTKAIRKAV TEQHELNPYA
     IVLLKTGSIP KTSSGKIQRH ACKAGFLEGS LQVVGEWQSG RREQPFARMH SSVYQLPVAS
     QKQISIQNWL VENIAQRLGV DVSEIDIQEP FATLGLDSVQ AVRLSADLED WLEVKLSPTV
     IYDYPNIISL ASYLVQEEQE EIDVENINQK LINSDIAIVG MGCRFPGANN PQEFWQLLRD
     GKDAISKVKG RWQGEDWGGF IENVDQFDPQ FFGITPRETQ RMDPQQRLLL EVSWEALENA
     GIASEQLTGS ATGIFIGISS SDYSQLQLHY GTEIDAYAGT GNAHSIAANR LSYSLDLRGP
     SLTLDTACSS SLVAVHLACQ SLKQGECQVA IAGGVNLMLS PELTETFSLA GMMAGDGRCK
     TFDAEADGYV RGEGCGVIIL KRLEEARRDR DNILAVIKGS AINQDGKSNG LTAPNGLAQQ
     AVIRQALINA GVQAGDISYV EAHGTGTKLG DPIEVNSLKN VLMQGRKENQ TCYLGSVKTN
     IGHLEAAAGI AGLIKTVLCL QNQVIPANLH FNQLNPHINL AQTPIQIPND LQPWQVEDKP
     RLAGVSSFGF GGTNAHVILQ EADKQTQNSE LIERPLHLFT ISAKNELALQ ELVGNYAKFL
     QNNSDISLAD FCYTANTGRT HFEHRLALVT ESKDDLINKL INFQTDNKIT RLNYSLVDKN
     NRTKIAFLFT GQGSQYIGMG YQLYQTQPTF RQALDRCDQI LQPYLEKSLI EVLYPNNVEI
     IDELSLQDLH KTAYTQPAIF AVEYALAQLW LSWGIQPDLV MGHSVGEYVA AVIAGIFSLE
     DGLQLIAERG RLMQALPQQG AMYAVFANES IVQSVIEGYS EQVSIAAINS PQNIVISGEE
     TALQQIISKL ESQGINSKKL NVSHAFHSPL MQPILADFAK VAEKVTYSLP QIQIISNVTG
     KIITEEITTA QYWINHVIEP VKFAQGMQSL EQEKSQILLE VGAKPILLGM GRQCVTKTQG
     LWLPSLRPRK QDWQQILHNL AELYSQGLKI NWQEFDQDYS RQKVALPTYP FQRQSYWLER
     KNQNNIVNTA RKLLPIQNNK IDFYKINWQQ LNINDLTITA KTWIIWTENQ ELGTKVAQQF
     QAKQQQCLLV NEQESLEKIV DCFRQNQQIA GIIYLDDLVD HQEQLTDRVI ITHYQKHCQS
     ILSLVQELFK QSITTSIWLV TKGSQNINEP INQSAIISSC LWGLGKAIAS EHPEYWGGLV
     DLSNNFSTEE IDSLITAINY SEKEDYLAIR NKQIYVARLQ ELELSKQSLK INSDSYLITG
     GLGALGLKLA QWLGDKGAKN LILVGRNKPS LAAQEIINKL ETKGTKVQVI QADITNLEAV
     NQIIAQYPSL KGIIHAAGVL NDGLLQNQTW ERFEQVITPK TIGAWNLHQA TQHLDLDFFV
     LFSSVASLIG SPGQGNYAVA NASLDAIALV RQAQGLPALS INWGPWANSG MAAAKGFNRQ
     GLHLIEPQSG LAVLEQLLSS KINHAQIGVL SVDWQELSQQ FPPLKQSNFF AELISLEETA
     ASSAKVQVFD DLLAIEPEKR TEYLTNYLQG AIAKILQVDP NQLATTDSLL DLGMDSLMLM
     EAINQLKGDL QLMLYPREFY ERPRIDHLAG YLAAEFTKTH DKSVGANRGS LLHNHHSVSD
     LLNQNKKSNH TKKSVSLQPP LSSPIAFILS SPRAGSTLLR VMLAGHPQLC SPPELHLLPF
     DTMSEREQEL GISQLGEGLK RAFMSLKGID AQASQELVAN LIKENLSVRD VYQLLQQLAG
     DRDRRERTSR SAPRQGRDRI LVDKSPTYAN NQETLAKAEA LFTNAKYIHL VRHPYAMIES
     FARMRMDKLI GAGDSNPYHV AESIWSNSNQ NILDLKTRIG SDRYFLVHYE ELVAQPEKVM
     REVCDFLAIP FDPGVLNPYQ GERMTDGVNN AGMSVGDPNF LNHKQIDANL ANAWREIRLP
     IVLDTLTQTI ARQLNYELLE EEINSTAHQE MREISINVRG LRICLCSWGP EEGPLVVCLH
     GILEQGAAWS EVAIRLAQKG YRVIAPDLRG HGRSDHVGKG GSYNLLDFLA DIDAIVENLA
     DRAFTLVGHS LGSVVAAIFA SIRPQQINNL VLVETILPSE VAEEQTAEQL ATHLDYLASP
     PEHPVFPNVE AAAERLRQGT PAISKALAML LAERITEPCE GGVRWRWAAL LRTRAGVGYN
     GIERSRYLGL LKRIKAPITL VYGDKSNFNR QEDLSAQQIA MPDAEKVVIP GGHNLPLEAP
     SALAKIISSA VALTNKLIP
//
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