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Database: UniProt/TrEMBL
Entry: L5KU26_PTEAL
LinkDB: L5KU26_PTEAL
Original site: L5KU26_PTEAL 
ID   L5KU26_PTEAL            Unreviewed;       911 AA.
AC   L5KU26;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   25-OCT-2017, entry version 22.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=PAL_GLEAN10013732 {ECO:0000313|EMBL:ELK14902.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14902.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; KB030555; ELK14902.1; -; Genomic_DNA.
DR   RefSeq; XP_006909433.1; XM_006909371.2.
DR   RefSeq; XP_006909434.1; XM_006909372.2.
DR   RefSeq; XP_015442850.1; XM_015587364.1.
DR   RefSeq; XP_015442851.1; XM_015587365.1.
DR   RefSeq; XP_015442852.1; XM_015587366.1.
DR   GeneID; 102888401; -.
DR   KEGG; pale:102888401; -.
DR   CTD; 3981; -.
DR   InParanoid; L5KU26; -.
DR   KO; K10777; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR021536; DNA_ligase_IV_dom.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF11411; DNA_ligase_IV; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:ELK14902.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT   DOMAIN      355    489       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      654    743       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      808    911       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   911 AA;  104255 MW;  363E1A4E352CCFF0 CRC64;
     MAASPTSQTV ASHVPFADLC STLERIQRSK GRAEKIRYFR EFLDSWRKFH DALHKNQKNV
     TDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP REGKDALKLL NYRTPTGTRG
     DAGDFAMIAY FVLKPRCLQK GSLSIQQVND ILDSVASNNS AKRKDLIKKS LLHFITQSSA
     LEQKWLIRMI IKDLRLGFSE QTVFSVFHND AAELHNVTTD LEKVCRQLHD PSIGLSDISI
     TLFSAFKPML AAIADIERIE KDMKNQSFYI ETKLDGERMQ MHKDGDIYEY FSRNGYKYTE
     QFGASPQEGS LTPFVHNAFK TDIQVCILDG EMMAYNPNTQ TFMQKGNKFD IKRMVEDSDL
     QTCYCVFDVL MVNNKKLGHE TLRKRYEILT SIFTPIPGRI EIVQKTQAHT KKEVIDALNE
     AIDKREEGIM VKHPLSIYKP DKRGEGWLKI KPEYVSGLMD ELDVIIVGGY WGKGSRGGMM
     SHFLCAVTEK PPSGEKPSVF HTLCRVGSGY TMKELYDLGL KLAKYWKPFH KKAPPRSIVC
     GTEKPEVYIE PCNSVIVQIK ATEIVPSDMY KTGCTLRFPR IEKIREDKEW RECMTLDDLE
     QLRGKASGKL ASKHFYVGGD DEPQEKKRKA APKTKKVIGI IEHLKAPNLS NINKVSSIFE
     DVEFCVMSGT ESCPKLDLEN RIAELGGYIV QNPGPDTYCI IAGSENIRVK NIISSNKHDV
     VKPEWLLECF NTKSCVPWQP RFMIHMCPST KQHFAREYDC YGDSYFIDTD LNQLKEVFSG
     IKNSSEQTPK EMASVIADLE YRYSWECSPL SMFRHYTIYL DLYTVINDLS TEIEGTRLAF
     TALELRFHGA KVVSCLAEGV SHVIVGEDHS RVVDFKAFRR TLKIKFKILQ DGWVTDSIDK
     CELQEEKQYL V
//
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