ID L8A2X4_9BACI Unreviewed; 530 AA.
AC L8A2X4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Putative acyl--CoA ligase {ECO:0000313|EMBL:AGE23381.1};
DE EC=6.2.1.- {ECO:0000313|EMBL:AGE23381.1};
GN ORFNames=GHH_c28700 {ECO:0000313|EMBL:AGE23381.1};
OS Geobacillus sp. GHH01.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX NCBI_TaxID=1233873 {ECO:0000313|EMBL:AGE23381.1, ECO:0000313|Proteomes:UP000011251};
RN [1] {ECO:0000313|EMBL:AGE23381.1, ECO:0000313|Proteomes:UP000011251}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GHH01 {ECO:0000313|EMBL:AGE23381.1};
RX PubMed=23618712;
RA Wiegand S., Rabausch U., Chow J., Daniel R., Streit W.R., Liesegang H.;
RT "Complete Genome Sequence of Geobacillus sp. Strain GHH01, a Thermophilic
RT Lipase-Secreting Bacterium.";
RL Genome Announc. 1:E0009213-E0009213(2013).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CP004008; AGE23381.1; -; Genomic_DNA.
DR RefSeq; WP_013144468.1; NC_020210.1.
DR AlphaFoldDB; L8A2X4; -.
DR KEGG; ggh:GHH_c28700; -.
DR PATRIC; fig|1233873.3.peg.3080; -.
DR HOGENOM; CLU_000022_59_10_9; -.
DR Proteomes; UP000011251; Chromosome.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR CDD; cd05972; MACS_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AGE23381.1}.
FT DOMAIN 19..383
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 433..512
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 530 AA; 59309 MW; 6CE7868AC7C36EC8 CRC64;
MRREDLIAPE RYNLTSEMER HAAAGPDRIA LKWESEQGET KEITYGRLMA RANQIGNAFL
SHGLEKGDKV LVMMPRLIET YEVYIGALKA GLVVIPSSEM LRTKDLQYRL VHSEAKAVVA
YAPYTDEFAP IDGIERLTKF VIGEPRDGWI PLEDAMAKES ETLEAADTSR DDMAFLSYTS
GTTGNPKGVV HCHGWAYAHL RTAAKNWLCI EEGDLVWATA GPGWQKWIWS PFLSVLGSGA
TGFVYYGRFE PEKYLQLLEK YNINVLCCTP TEYRLMAKVP DIGRYHLSHL HSAVSAGEPL
NREVIDTFAK HFGVEVRDGY GQTENTLLVG VMKGMPIKPG SMGKPTPGNR VEIIDENGEP
CPPGQVGDIA VHIETPALFK YYYKDPERTA MQFRGDYYIT GDKARKDEDG YFWFEGRGDD
IIISAGYTIG PFEVEDALVK HPAVKECAVV ASPDEVRGHV VKAFVVLRDG VDKDDPSLIP
ALQEHVKQLT APYKYPRKIE FVDDLPKTAS GKIRRVELRE REARLAGRSS
//
