ID L9L452_TUPCH Unreviewed; 516 AA.
AC L9L452;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Aldehyde dehydrogenase X, mitochondrial {ECO:0000256|ARBA:ARBA00040048};
DE EC=1.2.1.3 {ECO:0000256|ARBA:ARBA00024226};
DE AltName: Full=Aldehyde dehydrogenase family 1 member B1 {ECO:0000256|ARBA:ARBA00041645};
GN ORFNames=TREES_T100017569 {ECO:0000313|EMBL:ELW69851.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW69851.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol:
CC step 2/2. {ECO:0000256|ARBA:ARBA00037885}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR EMBL; KB320515; ELW69851.1; -; Genomic_DNA.
DR RefSeq; XP_006143784.1; XM_006143722.2.
DR AlphaFoldDB; L9L452; -.
DR STRING; 246437.L9L452; -.
DR GeneID; 102470232; -.
DR KEGG; tup:102470232; -.
DR CTD; 219; -.
DR eggNOG; KOG2450; Eukaryota.
DR InParanoid; L9L452; -.
DR OrthoDB; 2291791at2759; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07141; ALDH_F1AB_F2_RALDH1; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF207; ALDEHYDE DEHYDROGENASE X, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 44..507
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 284
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 516 AA; 57236 MW; EACA4F2585C7571E CRC64;
MLRFLVPRLL CLRGGTAPYS SAALPRPILN PDIRYNQLFI NNEWQDAISK KTFPTVNPTT
GEVIGHVAEG DRADVDRAVK AAREAFRLGS PWRRMDASQR GLLLNRLADL VERDRVYLAS
LETLDNGKPF QESYALDLDE VIKVYRYFAG WADKWHGKTI PMDGEHFCFT RHEPVGVCGQ
IIPWNFPLVM QGWKLAPALA TGNTVVMKVA EQTPLTALYL ASLIKEAGFP PGVVNIITGY
GPTAGAAIAQ HMDIDKVAFT GSTEVGHLIQ KAAGESNLKR VTLELGGKSP SIVLADADMG
HAVEQCHEAL FFNMGQCCCA GSRTFIEESI YDEFLERTVE KAKQRKVGNP FELDTQQGPQ
VDKEQFERIL GYIQLGQKEG ARLLCGGERF GERGFFIQPT VFGGVQDDMR IAKEEIFGPV
QPLFKFKKIE EVIERANNTR YGLAAAVFTQ DLDKAMYFTQ ALQAGTVWVN TYNIVTCHTP
FGGFKESGNG RELGEDGLKA YTEVKTVTIK VPQKNS
//