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Database: UniProt/TrEMBL
Entry: M1V5V4_CYAM1
LinkDB: M1V5V4_CYAM1
Original site: M1V5V4_CYAM1 
ID   M1V5V4_CYAM1            Unreviewed;       773 AA.
AC   M1V5V4;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   05-JUL-2017, entry version 27.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   ORFNames=CYME_CMN233C {ECO:0000313|EMBL:BAM81325.1};
OS   Cyanidioschyzon merolae (strain 10D) (Red alga).
OC   Eukaryota; Rhodophyta; Bangiophyceae; Cyanidiales; Cyanidiaceae;
OC   Cyanidioschyzon.
OX   NCBI_TaxID=280699 {ECO:0000313|EMBL:BAM81325.1, ECO:0000313|Proteomes:UP000007014};
RN   [1] {ECO:0000313|EMBL:BAM81325.1, ECO:0000313|Proteomes:UP000007014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=10D {ECO:0000313|EMBL:BAM81325.1,
RC   ECO:0000313|Proteomes:UP000007014};
RX   PubMed=15071595; DOI=10.1038/nature02398;
RA   Matsuzaki M., Misumi O., Shin-i T., Maruyama S., Takahara M.,
RA   Miyagishima S., Mori T., Nishida K., Yagisawa F., Nishida K.,
RA   Yoshida Y., Nishimura Y., Nakao S., Kobayashi T., Momoyama Y.,
RA   Higashiyama T., Minoda A., Sano M., Nomoto H., Oishi K., Hayashi H.,
RA   Ohta F., Nishizaka S., Haga S., Miura S., Morishita T., Kabeya Y.,
RA   Terasawa K., Suzuki Y., Ishii Y., Asakawa S., Takano H., Ohta N.,
RA   Kuroiwa H., Tanaka K., Shimizu N., Sugano S., Sato N., Nozaki H.,
RA   Ogasawara N., Kohara Y., Kuroiwa T.;
RT   "Genome sequence of the ultrasmall unicellular red alga
RT   Cyanidioschyzon merolae 10D.";
RL   Nature 428:653-657(2004).
RN   [2] {ECO:0000313|EMBL:BAM81325.1, ECO:0000313|Proteomes:UP000007014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=10D {ECO:0000313|EMBL:BAM81325.1,
RC   ECO:0000313|Proteomes:UP000007014};
RX   PubMed=17623057; DOI=10.1186/1741-7007-5-28;
RA   Nozaki H., Takano H., Misumi O., Terasawa K., Matsuzaki M.,
RA   Maruyama S., Nishida K., Yagisawa F., Yoshida Y., Fujiwara T.,
RA   Takio S., Tamura K., Chung S.J., Nakamura S., Kuroiwa H., Tanaka K.,
RA   Sato N., Kuroiwa T.;
RT   "A 100%-complete sequence reveals unusually simple genomic features in
RT   the hot-spring red alga Cyanidioschyzon merolae.";
RL   BMC Biol. 5:28-28(2007).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
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DR   EMBL; AP006496; BAM81325.1; -; Genomic_DNA.
DR   RefSeq; XP_005537361.1; XM_005537304.1.
DR   STRING; 45157.CMN233CT; -.
DR   EnsemblPlants; CMN233CT; CMN233CT; CMN233C.
DR   GeneID; 16995467; -.
DR   Gramene; CMN233CT; CMN233CT; CMN233C.
DR   KEGG; cme:CYME_CMN233C; -.
DR   KO; K00627; -.
DR   OMA; KAVARNM; -.
DR   Proteomes; UP000007014; Chromosome 14.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   Gene3D; 4.10.320.10; -; 2.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR004167; E3-bd.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 2.
DR   Pfam; PF02817; E3_binding; 2.
DR   SUPFAM; SSF47005; SSF47005; 2.
DR   SUPFAM; SSF51230; SSF51230; 2.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 2.
DR   PROSITE; PS00189; LIPOYL; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007014};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007014};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:BAM81325.1}.
FT   DOMAIN       80    155       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN      233    311       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
SQ   SEQUENCE   773 AA;  81331 MW;  08B4CAF50338C494 CRC64;
     MVLDGAGHAL SLAFVGGIPT SKRRAAVRPG SRPRGSPPFW SNFPCTWRWG SARMRLAPRQ
     LGRSFLRMEV SPEVRERVQA HEVFMPALSS TMTEGKVVQW LKKVGDRIEK GDVILVVESD
     KADMDVEAFD EGYLAHILTK EGETAVVGAT IGLIAKNVED IEAIQACGLD CIVDGSGSRH
     DGTTAVEPGD AAPAPSTHQR ESAAERSAAF GGRDAIVTAP AAAAPLVPKP AGTVEVFLPA
     LSSTMTEGKI VEWTKNIGDE VKSGDVIMVV ESDKADMDVE SFETGFLAHI ELEAGISAPV
     GAVAGYLARD KASVPLVQAW AKSAARELDQ APGESSAAVR STAPGSESAP VTTPEHVAIS
     TPTPTPTSTE IQEDDLAPGG ESMTAPTGRV IASPYAKRLA KENKIDLRTL RGRGPGGRIL
     AADVQAAMLA RSAAQTPSVA SEKPLQASAV SGRMIATPGA KKLAKSRGVD LAKVRGTGPY
     GRITEADVKR ALGEASSDSQ TSAPTASAEA AVTSERRSTG SDAGAETERK ARRGASSADA
     APATEKAALS GPVPMSTMQK AVVNNMNASL QVPVFRVSYS ITTDAVDALL SKLKSKGVTM
     TTLLAKALGL TLRKHPLLNA RFEEPYTIVY QPGANIAVAV ALPDGGLITP VLRDCADTDI
     YELSRRWRSL VRLALEKKLK PEDYQSGTFS LSNLGMFGVS SFDAILPKGT GAILAVAASQ
     PQVRLQSNGL IGVSKVMQVT ITCDHRHIYG AQAAEFLRDL ADLLEKRVEE LLL
//
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