ID M4A9Z6_XIPMA Unreviewed; 891 AA.
AC M4A9Z6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Exosome component 10 {ECO:0000313|Ensembl:ENSXMAP00000011290.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000011290.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000011290.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000011290.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR RefSeq; XP_005808259.1; XM_005808202.2.
DR AlphaFoldDB; M4A9Z6; -.
DR STRING; 8083.ENSXMAP00000011290; -.
DR Ensembl; ENSXMAT00000011304.2; ENSXMAP00000011290.1; ENSXMAG00000011246.2.
DR GeneID; 102225741; -.
DR KEGG; xma:102225741; -.
DR CTD; 5394; -.
DR eggNOG; KOG2206; Eukaryota.
DR GeneTree; ENSGT00390000015408; -.
DR HOGENOM; CLU_010129_1_1_1; -.
DR InParanoid; M4A9Z6; -.
DR OMA; NIMRPQM; -.
DR OrthoDB; 2880475at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 503..583
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..818
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 891 AA; 102064 MW; 6D858FCA2CD43CF2 CRC64;
MMKASKKKES TNSGSLDDDP DANREESEIC PGFKDADAFV KYGLGAVISA TKASAGLPVA
GDEYDFYRSF PGFQEFCESQ GDKLLHCMSQ IMQHHGCRSH IRDRNKLTGL EERFDLVVDS
NDVILERAGI LLDEADGVNR SQNPVMPAGF QPPKIVVSSW NRKGSSSGSR SETFRLLHAK
NVARPQLKFK EKVDNSNTPF VPKIFIKPNA LKPLPTYFSN KQIRKERPED LDVPAALADF
IHQQRTQEHV DDMFAHPYQY ELDHLTIPER LLSKPEPQMY KPMAETKLSF IDSLEDLVAL
NEKLCRLSEF AVDLEHHSYR SFLGITCLMQ ISTREEDFII DTLELRSEMH ILNEAFTDPT
IVKVFHGADS DIEWLQRDFG LYVVNLFDTH QASRALNLAR HSLDHLLKNF CNVNSDKRYQ
LADWRIRPLP EEMIEYARAD THYLLYIYDC MRAQLLESNH GQPGLLQCVW NKSKDVSFKK
YMKPIFTEES YLELQRKQKR SFNTQQLTTF RLLYAWRDKL ARQEDESTGY VLPTHMMIKI
SEEMPKEPQG IIACCNPVPP LVRQQVNELH LLVQQGREMP LLKAEVAAQK KKGLTTIKKA
EVPLFGPHDT SRGSESSHPQ LIADEVPVKQ GILFSEEVYK MDVDEQKISS LLAPAKITLF
KELETPAGQK SLSVAQMKAR SITESFENPF RMYLPSTGAH VNKNAKFDPS SKIFEISKRW
KLQSAEQQQK EMEVKKKSKE EAKQKAKKLS EERTKAKQSY QESLRNIVPV RQQATDSKDG
GRKKARGGSE VGEMTPKPSK KLMKSAEKSQ KTEPPSEETF KPFDYAQSDL KVFDGSKAKD
NMQFDPNRQA QEFRKKKRPQ GQKNNFSSGN RSMSYMKGKS DRGFRHAWPK R
//
