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Database: UniProt/TrEMBL
Entry: M4WXR9_9PSED
LinkDB: M4WXR9_9PSED
Original site: M4WXR9_9PSED 
ID   M4WXR9_9PSED            Unreviewed;       740 AA.
AC   M4WXR9;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   22-NOV-2017, entry version 30.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AGI24609.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AGI24609.1};
GN   ORFNames=H681_13695 {ECO:0000313|EMBL:AGI24609.1};
OS   Pseudomonas sp. ATCC 13867.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1294143 {ECO:0000313|EMBL:AGI24609.1, ECO:0000313|Proteomes:UP000012082};
RN   [1] {ECO:0000313|EMBL:AGI24609.1, ECO:0000313|Proteomes:UP000012082}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13867 {ECO:0000313|EMBL:AGI24609.1,
RC   ECO:0000313|Proteomes:UP000012082};
RX   PubMed=23723394;
RA   Ainala S.K., Somasundar A., Park S.;
RT   "Complete Genome Sequence of Pseudomonas denitrificans ATCC 13867.";
RL   Genome Announc. 1:E00257-13(2013).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP004143; AGI24609.1; -; Genomic_DNA.
DR   RefSeq; WP_015477465.1; NC_020829.1.
DR   EnsemblBacteria; AGI24609; AGI24609; H681_13695.
DR   GeneID; 32563232; -.
DR   KEGG; pdr:H681_13695; -.
DR   PATRIC; fig|1294143.3.peg.2764; -.
DR   KO; K00031; -.
DR   OrthoDB; POG091H0B3N; -.
DR   Proteomes; UP000012082; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000012082};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AGI24609.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000012082}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       349    349       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       547    547       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       551    551       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     546    546       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        254    254       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        419    419       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   740 AA;  81607 MW;  8EB24711CCB77832 CRC64;
     MSIRSKITYT FTDEAPALAT YSLLPIVKAF AASAGIDVET RDISLAGRIL ASFADKLGDQ
     AIEDDLAYLA QLATAPEANI IKLPNISASV PQLKGAIAEL QKLGYAVPDL PEDPQTDEEN
     DTRARYAKVL GSAVNPVLRE GNSDRRAPAA VKAYARKHPH SMGKWSMASR SHADYMRGGD
     FFSSEQSVTI PQAGDVRLEF VGKDGKVEVK KTLKMQEGEV LDSMFMSCGK LRDFFEKTLQ
     DCKETGVMWS LHVKATMMKI SHPIVFGHAV TVYYKDVFDK YGKLFEELGV NPNNGISSVY
     DKIKSLPASQ QEEILHDIHE VYSHRPEMAM VDSVKGITNL HIPSDVIVDA SMPAMIRNSG
     QMWGKDGKQK DTKAVMPEST YARMYQEMIN FCKTNGAFDP TTMGSVPNVG LMAQKAEEYG
     SHDKTFEMEA DGTMRVVDAD GKVLMQHEVQ AGDIWRACQT KDAPIRDWVK LAVTRARQSN
     TPAIFWLDPE RAHDNELRKK VELYLQDYDL TGLNISIKDY NEAIRTSMER QIRGLDTISV
     TGNILRDYLT DLFPIMELGT SAKMLSIVPL MAGGGMYETG AGGSAPKHVQ QLVEENYLRW
     DSLGEFLALA VSFEEEGIKT GNAKAKVLSK TLDEATGKLL DNNKSPSRKV GEIDNRGSHF
     YLAMYWAQAL AAQNDDAELK AHFSALAKTL TEQEATIVAE LNGVQGKPAD IGGYYRSNPE
     LTSQVMRPSA TFNAAIDALA
//
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