ID M8CB18_AEGTA Unreviewed; 732 AA.
AC M8CB18;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=hexokinase {ECO:0000256|ARBA:ARBA00012324};
DE EC=2.7.1.1 {ECO:0000256|ARBA:ARBA00012324};
OS Aegilops tauschii (Tausch's goatgrass) (Aegilops squarrosa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=37682 {ECO:0000313|EnsemblPlants:EMT31348};
RN [1] {ECO:0000313|EnsemblPlants:EMT31348}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225}.
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DR AlphaFoldDB; M8CB18; -.
DR EnsemblPlants; EMT31348; EMT31348; F775_19857.
DR UniPathway; UPA00109; UER00180.
DR UniPathway; UPA00242; -.
DR ExpressionAtlas; M8CB18; baseline.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004340; F:glucokinase activity; IEA:UniProt.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.40.367.20; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR019807; Hexokinase_BS.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR InterPro; IPR009686; Senescence/spartin_C.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF14; HEXOKINASE-9; 1.
DR Pfam; PF00349; Hexokinase_1; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR Pfam; PF06911; Senescence; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00378; HEXOKINASE_1; 1.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 39..224
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 231..440
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
FT DOMAIN 528..714
FT /note="Senescence"
FT /evidence="ECO:0000259|Pfam:PF06911"
SQ SEQUENCE 732 AA; 78120 MW; E127D16D4713214A CRC64;
MRKAAALAAA AVVATAAAIA VRQRLREAKR WARVAAVLSD LQERCAAPAA QLLQVSDAMD
VEMRAGLASE DGSKLKMLVT YVDSLPSGDE KGLFYALDLG GTNFRVLRVQ LGGKEQGVIK
QESVGELFDF IAAALAEFVA SGGVDYHLPE GTHRELGFTF SFPVKQTSIS SGTLIKWTKG
FAIEEMAGKD IVAELNEAIK RQGLVMKVST LVNDTVGTLA AGRYVDNDTV VAVILGTGTN
AAYIEHAHAI PKWHGPLPMS GDMVINMEWG NFKSAHLPLT EFDQALDAES LNPGEQIYEK
LTSGMYMGEI VRRILLQMAQ EAALFGDNIP PKLEIPYILK TFHMLVMHHD ASPDLETVGI
KLKEIFEIES TSRKTRKLVV DVCKVIATRG ARLAAAGIHG ILKKLGRATD SPDKRRTVIA
VDGGVYKYYT FFNKECVSKV SPNVLTLKDG IKARPQRRRR LLNYGVSFAD AALLPSFDSL
LKSNSCFSTP SAPSRGSRPP PPASASPDAY WNDFSSKVES YNNVLAKAIG AGTGHLVKGI
FMCSEAYASQ VQKGANLINP QAAGGASKRF GGAGGADGSS QAGPAKRGGV NKSLKRVRKL
SEMTEKMSKT MLDTVISVTG SMAAPLLRSN QGKALLSTVP GEVVIASLDA INKVMDAVEA
AERRSLAATS NVVSGAVSKR YGESAGEATG DAFATVGHTV GTAWNIFKIR KAVTPSSSLP
GNMVKSAVRN RN
//
