GenomeNet

Database: UniProt/TrEMBL
Entry: O97245_PLAF7
LinkDB: O97245_PLAF7
Original site: O97245_PLAF7 
ID   O97245_PLAF7            Unreviewed;       653 AA.
AC   O97245;
DT   01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1999, sequence version 1.
DT   27-SEP-2017, entry version 101.
DE   RecName: Full=Glycerol-3-phosphate dehydrogenase {ECO:0000256|RuleBase:RU361217};
DE            EC=1.1.5.3 {ECO:0000256|RuleBase:RU361217};
GN   ORFNames=PF3D7_0306400 {ECO:0000313|EMBL:CAB39011.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAB39011.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|EMBL:CAB39011.1, ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=10448855; DOI=10.1038/22964;
RA   Bowman S., Lawson D., Basham D., Brown D., Chillingworth T.,
RA   Churcher C.M., Craig A., Davies R.M., Devlin K., Feltwell T.,
RA   Gentles S., Gwilliam R., Hamlin N., Harris D., Holroyd S., Hornsby T.,
RA   Horrocks P., Jagels K., Jassal B., Kyes S., McLean J., Moule S.,
RA   Mungall K., Murphy L., Oliver K., Quail M.A., Rajandream M.-A.,
RA   Rutter S., Skelton J., Squares R., Squares S., Sulston J.E.,
RA   Whitehead S., Woodward J.R., Newbold C., Barrell B.G.;
RT   "The complete nucleotide sequence of chromosome 3 of Plasmodium
RT   falciparum.";
RL   Nature 400:532-538(1999).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [3] {ECO:0000313|EMBL:CAB39011.1, ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + a quinone =
CC       glycerone phosphate + a quinol. {ECO:0000256|RuleBase:RU361217}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|RuleBase:RU361217};
CC   -!- SIMILARITY: Belongs to the FAD-dependent glycerol-3-phosphate
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU361217}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AL844502; CAB39011.1; -; Genomic_DNA.
DR   RefSeq; XP_001351140.1; XM_001351104.1.
DR   ProteinModelPortal; O97245; -.
DR   SMR; O97245; -.
DR   EnsemblProtists; CAB39011; CAB39011; PF3D7_0306400.
DR   GeneDB; PF3D7_0306400.1:pep; -.
DR   GeneID; 814382; -.
DR   KEGG; pfa:PFC0275w; -.
DR   EuPathDB; PlasmoDB:PF3D7_0306400; -.
DR   HOGENOM; HOG000004813; -.
DR   InParanoid; O97245; -.
DR   KO; K00111; -.
DR   OMA; VPYYWVG; -.
DR   PhylomeDB; O97245; -.
DR   Reactome; R-PFA-1483166; Synthesis of PA.
DR   Reactome; R-PFA-163560; Triglyceride catabolism.
DR   Proteomes; UP000001450; Chromosome 3.
DR   GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005739; C:mitochondrion; ISS:GeneDB.
DR   GO; GO:0004368; F:glycerol-3-phosphate dehydrogenase activity; ISS:GeneDB.
DR   GO; GO:0052591; F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006127; P:glycerophosphate shuttle; ISS:GeneDB.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR031656; DAO_C.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR000447; G3P_DH_FAD-dep.
DR   PANTHER; PTHR11985; PTHR11985; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16901; DAO_C; 1.
DR   PRINTS; PR01001; FADG3PDH.
DR   SUPFAM; SSF51905; SSF51905; 2.
DR   PROSITE; PS00977; FAD_G3PDH_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Flavoprotein {ECO:0000256|RuleBase:RU361217};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU361217,
KW   ECO:0000313|EMBL:CAB39011.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN       59    399       DAO. {ECO:0000259|Pfam:PF01266}.
FT   DOMAIN      498    632       DAO_C. {ECO:0000259|Pfam:PF16901}.
SQ   SEQUENCE   653 AA;  74688 MW;  D2914FC6FECA11CA CRC64;
     MIKKVAICSG TLGILSYGGF YFLKINFQKN MIDKDVTYKY SPCIKRNEMI KKLQENQYDL
     LIIGGGATGA GLALDAATRG LKCALVEKND FSSGTSSKST KLLHGGIRYL ENAVNNLDFT
     ELYFVWEALA ERAHTMKIAP YLSRPVSILM PIYKYWQVPY FSYNIKIYDL LADLVCYFDK
     GVPNSLYIRK SNTIDNFPLL RKDKLKGSLI YFDGQHDDSR MNLNLILTSA IDNYVPGQIG
     ATVCNHMEVK NFIKDENNKL VGVRAIDKIN DKEIEIFSKV IINATGPYGD IIRKLADENR
     KPMIQVSVGC HFILPKWYST KNNGMIIPKT SDDRVLFLLP WENNTLVGTT DEKRIMQDDP
     KIQEKDIEFL TNELSKYIHV SAEEIKNDIT AAWCGFRPLI STNNNKKSKF SSNKKKNNNN
     NINSNSSSNS NNFDDEQNNN NNNIGTHEIS RSHEIIEDDN GLISILGGKW TIYRKMAQDT
     LDYILRKYPN ELKTKYNCRT KFLKLIGCHD KYGIFNEDDL TFGCSKLSKT LVNKYPQIDF
     QTANHLVSNY GYLSENVCEL AKELNMFNKI DPTKPYIEAE IIYATRYEFA NTISDIIGRR
     FRLGFIDSQV SNKVIDKIAQ LLKNELTWNT EQVNKNVKEA KDYINSLSLK DTI
//
DBGET integrated database retrieval system