ID   Q02MP6_PSEAB            Unreviewed;       959 AA.
AC   Q02MP6;
DT   14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT   14-NOV-2006, sequence version 1.
DT   29-MAY-2013, entry version 59.
DE   RecName: Full=Glycine dehydrogenase [decarboxylating];
DE            EC=1.4.4.2;
DE   AltName: Full=Glycine cleavage system P-protein;
DE   AltName: Full=Glycine decarboxylase;
GN   Name=gcvP2; Synonyms=gcvP; OrderedLocusNames=PA14_33000;
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14;
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L.,
RA   Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC       glycine. The P protein binds the alpha-amino group of glycine
CC       through its pyridoxal phosphate cofactor; CO(2) is released and
CC       the remaining methylamine moiety is then transferred to the
CC       lipoamide cofactor of the H protein (By similarity).
CC   -!- CATALYTIC ACTIVITY: Glycine + H-protein-lipoyllysine = H-protein-
CC       S-aminomethyldihydrolipoyllysine + CO(2).
CC   -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC   -!- SUBUNIT: The glycine cleavage system is composed of four proteins:
CC       P, T, L and H (By similarity).
CC   -!- SIMILARITY: Belongs to the GcvP family.
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DR   EMBL; CP000438; ABJ11629.1; -; Genomic_DNA.
DR   RefSeq; YP_790790.1; NC_008463.1.
DR   ProteinModelPortal; Q02MP6; -.
DR   STRING; 208963.PA14_33000; -.
DR   EnsemblBacteria; ABJ11629; ABJ11629; PA14_33000.
DR   GeneID; 4380533; -.
DR   KEGG; pau:PA14_33000; -.
DR   PATRIC; 19851494; VBIPseAer79785_2696.
DR   eggNOG; COG1003; -.
DR   HOGENOM; HOG000239369; -.
DR   KO; K00281; -.
DR   OMA; QTMVCDL; -.
DR   ProtClustDB; PRK05367; -.
DR   BioCyc; PAER208963:GI5K-2676-MONOMER; -.
DR   GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:HAMAP.
DR   Gene3D; 3.40.640.10; -; 2.
DR   HAMAP; MF_00711; GcvP; 1; -.
DR   InterPro; IPR020580; GDC-P_N.
DR   InterPro; IPR020581; GDC_P.
DR   InterPro; IPR003437; GDC_P_homo.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR   PANTHER; PTHR11773; PTHR11773; 1.
DR   Pfam; PF02347; GDC-P; 2.
DR   SUPFAM; SSF53383; PyrdxlP-dep_Trfase_major; 2.
DR   TIGRFAMs; TIGR00461; gcvP; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Oxidoreductase; Pyridoxal phosphate.
FT   MOD_RES     711    711       N6-(pyridoxal phosphate)lysine (By
FT                                similarity).
SQ   SEQUENCE   959 AA;  103889 MW;  9599CBAEF1D0C083 CRC64;
     MTDNLNLGTI DLGTDDEFIA RHIGPRAADT QAMLQRLGYD SLDTLIGNVI PDSIKGSSVL
     DLPAGMGEAE ALASLKAIAA RNRALRSFIG QGYYNCHTPA PILRNLLENP AWYTAYTPYQ
     PEISQGRLEA LLNFQTLVSD LSGLPIANAS MLDEATAAAE AMTFCKRLSK NRTSQAFFAS
     RHCHPQTLDV LRTRAEPLGI EVVVGDESAI EDFSAYFGAL LQYPTCDGEI VDYRELVSRF
     HAVDALVAVA ADLLALTLLT PPGEFGADVA IGSAQRFGVP LGFGGPHAAY FATRDAFKRD
     MPGRLVGVSI DRHGKPAYRL AMQTREQHIR REKATSNICT AQVLLANIAS MFAVYHGPQG
     LLRIARRTHR LTAILAAGLE RLGVAVEQKH FFDTLSLATG ARTAAIHAKA RAAGINLREI
     DAGRLGLSLD ETVRQADVET LWGLLAEEGQ ALPDFAALAA SSGDRLPVEL LRQSAILSHP
     IFNRHHSETE LMRYLRKLAD KDLALDRTMI PLGSCTMKLN AASEMIPVTW AEFGNLHPFA
     PAEQSEGYRQ LTDELEAMLC SATGYDAVSL QPNAGSQGEY AGLLAIRAYH QSRGDSQRDI
     CLIPSSAHGT NPATASMVGM RVVVVACDAR GNVDVEDLRN KASEHKERLA ALMITYPSTH
     GVFEEAIREI CAIVHDCGGQ VYIDGANMNA MVGLCAPGKF GGDVSHLNLH KTFCIPHGGG
     GPGVGPIGVR AHLAPFLPGH ARGERKEGAV SAAPYGSASI LPITWMYIRM MGGEGLKRAS
     EMAILNANYI AHRLEEHYPV LYAGGNGLVA HECILDLRPL KDSSGISVDD VAKRLMDFGF
     HAPTMSFPVA GTLMIEPTES ESKAELDRFC DAMIRIREEI RAVERGELDK EDNPLKNAPH
     TAAELLGEWN HAYSREQAAY PLASLVEAKY WPPVGRVDNV YGDRNLTCSC PPIEAYSEE
//